Does blood group affect survival following pancreatoduodenectomy for periampullary malignancy?

Khalil, Khalid; Bansal, Sukhchain; Ayaani, Soofiyah; Hodson, James; Lam, F. T.; Khan, Saboor; Ahmad, Jawad; Isaac, John; Muiesan, Paolo; Mirza, Darius F.; Dasari, Bobby; Marudanayagam, R.; Sutcliffe, Robert P.; Marangoni, Gabriele; Roberts, Keith

doi:10.1016/j.hpb.2018.03.009

Cited by 3 publications

(3 citation statements)

References 23 publications

(32 reference statements)

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“…However, the results of this study stand in contrast to recent work by Khalil et al 12 and Rahbari et al, 14 both of whom found a significant survival advantage in patients with blood group O. Notably, Khalil et al 12 found a significant survival difference when comparing ABO blood group across all periampullary cancers, but this difference disappeared when looking exclusively at PDAC patients. Rahbari et al 14 found a significant survival difference only on multivariate, but not on univariate analysis of blood groups.…”

Section: Discussioncontrasting

confidence: 99%

“…These results are in line with previous work by Dandona et al, 17 Wang et al 15 and El Jellas et al, 16 all of whom found no survival advantage in patients with blood group O. However, the results of this study stand in contrast to recent work by Khalil et al 12 and Rahbari et al, 14 both of whom found a significant survival advantage in patients with blood group O. Notably, Khalil et al 12 found a significant survival difference when comparing ABO blood group across all periampullary cancers, but this difference disappeared when looking exclusively at PDAC patients.…”

Section: Discussionsupporting

confidence: 90%

“…[9][10][11] While there appears to be a connection between ABO blood groups and pancreatic cancer incidence, the prognostic implications of this information remain unclear. Previous research on this topic has yielded mixed results, with some small studies finding a survival advantage among patients with blood group O [12][13][14] and others finding no difference in outcomes between blood groups. [15][16][17] Using a large cohort of patients from a highvolume pancreatic cancer treatment health system, this study assessed whether ABO blood group impacts overall survival in patients who undergo pancreatoduodenectomy (PD) for PDAC.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Association of ABO blood group with survival following pancreatoduodenectomy for pancreatic ductal adenocarcinoma

Williams

Jajja

Hashmi

et al. 2020

HPB

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

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Association of ABO blood group with survival following pancreatoduodenectomy for pancreatic ductal adenocarcinoma

Williams

Jajja

Hashmi

et al. 2020

HPB

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Prognostic value of ABO blood groups in upfront operated pancreatic ductal adenocarcinomas

Joliat,

Labgaa,

Martin

et al. 2024

Langenbecks Arch Surg

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Purpose Pancreatic ductal adenocarcinoma (PDAC) has been shown to have a lower incidence in patients with blood group O. It is currently uncertain if patients with group O have a better prognosis after pancreatectomy. This study assessed the overall survival (OS) and disease-free survival (DFS) of PDAC patients who underwent upfront pancreatoduodenectomy based on ABO blood groups. Methods A cross-sectional study was performed including patients from two university centers. All consecutive head PDAC patients who underwent upfront pancreatoduodenectomy from 2000 to 2016 were included. OS and DFS were compared between blood groups A, B, AB, and O using Kaplan-Meier curves and log-rank tests. Results A total of 438 patients were included (215 women, median age 67). Pre- and intraoperative details were comparable between all subgroups. Median OS did not differ between the four blood groups (A: 23 months, 95% CI 18–28; B: 32, 95% CI 20–44; AB: 37, 95% CI 18–56 and O: 26, 95% CI 20–32, p = 0.192). Median DFS were also similar (A: 19 months, 95% CI 15–23; B: 26, 95% CI 19–33; AB: 35, 95% CI 15–55 and O: 22, 95% CI 15–29, p = 0.441). There was no OS difference between O and non-O groups (median: 26 months, 95% CI 20–33 vs. 25 months, 95% CI 20–30, p = 0.773). On multivariable analysis blood groups were not prognostic of OS. Only lymph node involvement, tumor differentiation, and adjuvant chemotherapy were independent prognostic factors. Conclusion OS and DFS were similar between all four blood groups after pancreatoduodenectomy. Independent predictors of OS were associated with tumor characteristics and adjuvant treatment.

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ABO blood group distribution and risk of malignancy in patients undergoing resection for intraductal papillary mucinous neoplasm (IPMN)

et al. 2022

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Does blood group affect survival following pancreatoduodenectomy for periampullary malignancy?

Abstract: There is a difference in the distribution of blood groups across the different types of periampullary cancers. Survival is shorter among blood group A patients.

Cited by 3 publications

References 23 publications

Association of ABO blood group with survival following pancreatoduodenectomy for pancreatic ductal adenocarcinoma

Association of ABO blood group with survival following pancreatoduodenectomy for pancreatic ductal adenocarcinoma

Prognostic value of ABO blood groups in upfront operated pancreatic ductal adenocarcinomas

ABO blood group distribution and risk of malignancy in patients undergoing resection for intraductal papillary mucinous neoplasm (IPMN)

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