ABO blood groups in relation to breast carcinoma incidence and associated prognostic factors in Moroccan women

Abstract

The association between blood groups ABO and different types of diseases was established in several previous studies. Our aim was to seek the possible association between the ABO blood group and breast cancer-associated prognostic factors. The Chi-squared analytic test was used to compare phenotypic ABO distribution among Moroccan blood donors and 442 cases of women suffering from breast carcinoma with archived files in Maternity Ward of University Hospital C.H.U Ibn Rochd between 2008 and 2011. High incidence of breast carcinoma was observed in blood type B patients (p < 0.05). Blood type B was associated with breast carcinomas overexpressing human epidermal growth factor receptor HER2 (p < 0.05) and high risk of cancer at age over 70 years (p < 0.001). Blood type A was associated with high risk of cancer among women younger than 35 years old. Blood type A and AB were associated with high incidence of lymph node metastasis (p < 0.05). Multivariate analysis has shown correlation between O blood type and estrogen receptor-positive tumor. Patients with blood group A, B, and AB were more likely to develop aggressive breast carcinoma. Further follow-up studies are necessary to clarify the role of ABH antigens in the progression of breast carcinoma.

Clinical Associations with ABO Blood Group and Rhesus Blood Group Status in Patients with Breast Cancer: A Nationwide Retrospective Study of 3,944 Breast Cancer Patients in Turkey

“…Also, a Korean study did not show any difference in the distribution of blood groups of young patients with breast cancer when compared with an age-matched healthy population [ 8 ]. However, a study from Morocco showed that the incidence of breast cancer was increased in patients with blood group type B [ 9 ]. Published data from a meta-analysis showed that Caucasians with blood group type A were at an increased risk of developing breast cancer when compared with non-Caucasians [ 5 ].…”

Blood type evaluation in breast cancer patients at an oncology center in Agreste Pernambucano

“…No entanto, outros estudos apoiam as associações significativas entre o tipo sanguíneo e o risco de câncer de mama [24][25][26][27] . As razões plausíveis para a disparidade entre os resultados incluem heterogeneidade nas características das populações, tamanhos de estudos limitados e diferenças na distribuição ABO 21 .…”

ABO Blood Group Genotypes in Women with Breast Cancer

“…The study by Tryggvadottir et al from Iceland conducted on 184 breast cancers inherited in families and 572 sporadic cases showed the risk of disease to be statistically significant for B blood group carriers 15 . In their study on a population of 442 women in Morocco, Zouine et al report on a high incidence of breast cancers in B blood group women 22 .…”