ABO Blood Groups and Genetic Risk Factors for Thrombosis in Croatian Population

Jukić, Irena; Bingulac-Popović, Jasna; Babić, Ivana; Culej, Jelena; Tomičić, Maja; Vuk, Tomislav; Šarlija, Dorotea; Balija, Melita

doi:10.3325/cmj.2009.50.550

Cited by 30 publications

(35 citation statements)

References 22 publications

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“…In our study population, the prevalence of FVL was 17% in the VTE group, lower than that reported for Caucasians in South-East Europe (Serbia 29.9%, Croatia 21-28.2%, Hungary 44%) while in the control female group the prevalence was 8.3%, similar with other surrounding countries (5.8% Serbia, 6.9% Hungary) (28)(29)(30). Only the homozygous FVL was associated with VTE in our female population.…”

Section: Discussionsupporting

confidence: 49%

Thrombophilia genetic testing in Romanian young women with acute thrombotic events: role of Factor V Leiden, Prothrombin G20210A, MTHFR C677T and A1298C polymorphisms / Evaluarea genetică a trombofiliilor la femei tinere din România cu evenimente acute trombotice: rolul Factorului V Leiden, Protrombinei G20210A, polimorfismelor MTHFR C677T și A1298C

Daraban

Popp

Botezatu

et al. 2016

Revista Romana De Medicina De Laborator

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Section: Discussionsupporting

confidence: 49%

Thrombophilia genetic testing in Romanian young women with acute thrombotic events: role of Factor V Leiden, Prothrombin G20210A, MTHFR C677T and A1298C polymorphisms / Evaluarea genetică a trombofiliilor la femei tinere din România cu evenimente acute trombotice: rolul Factorului V Leiden, Protrombinei G20210A, polimorfismelor MTHFR C677T și A1298C

Daraban

Popp

Botezatu

et al. 2016

Revista Romana De Medicina De Laborator

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“…A recent systematic review examined five of these studies [ [65]. A third study (of a combined group of arterial thrombosis, venous thrombosis and thrombophebitis), also included FVL homozygotes [63]. From their data an overall crude OR of 3.07 (95% CI: 2.81-13.11) can be calculated for the thrombosis risk with FVL.…”

Section: Interaction Of Abo(h) and Other Thrombophilias In Vtementioning

confidence: 98%

“…As non-O blood groups are so common, a number of studies have examined whether blood group influences the VTE risk associated with these mutations [24,35,[61][62][63][64][65][66][67]. Some of these studies combined FVL homo zygotes and heterozygotes in their ana lysis.…”

Section: Interaction Of Abo(h) and Other Thrombophilias In Vtementioning

confidence: 99%

ABO Blood Groups and Thrombosis: A Causal association, But is There Value in screening?

Clark

2011

Future Cardiol.

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ABO(H) antigens are expressed on red cells and on von Willebrand factor. An association between groups other than O and thrombosis exists: an effect that is predominantly mediated by von Willebrand factor. Overall, the risk of venous thrombosis associated with non-O has been estimated at 1.75-fold, with a higher risk (∼ 2.4-fold) in those with the least O(H) antigen (a combined group of A(1)A(1)/A(1)B/BB). Preliminary evidence also suggests that blood group may influence the venous thromboembolism risk associated with factor V Leiden. Overall, ABO(H) has a more modest effect on arterial disease, with a consistent effect observed in peripheral vascular disease and no influence evident with angina. A modest effect on myocardial infarction and stroke has been reported in some but not all studies. The potential mechanisms whereby blood group influences thrombosis, the limitations of current evidence and the current and future role of blood groups in identifying those at risk of arterial and venous disease is discussed.

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“…Considering the association between blood alleles and coagulation factors, the evaluation of coagulation factors may be beneficial [24,25].…”

Section: Limitationsmentioning

confidence: 99%