ABO blood group and esophageal carcinoma risk: from a case–control study in Chinese population to meta-analysis

Wang, Wei; Liu, Lei; Wang, Zhiwei; Lu, Xiaopeng; Wei, Min; Lin, Tianlong; Zhang, Yixin; Jiang, Songqi; Wang, Qiang; Cao, Zhenfu; Shi, Minxin

doi:10.1007/s10552-014-0442-y

Cited by 18 publications

(12 citation statements)

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“…Many reports have shown that the ABO blood type system is associated with the development of cancers. Type A has been associated with gastric [ 13 – 15 ], pancreatic [ 16 – 19 ], ovarian [ 16 , 20 ], esophageal [ 21 ], salivary gland [ 21 ], and breast cancers [ 16 ], whereas type B has been associated with esophageal [ 22 , 23 ] and laryngeal cancers [ 21 ]. Some reports showed that people with blood type O have lower risks for lung [ 24 ], endometrial [ 25 ], pancreatic [ 26 ], renal cell [ 27 ], and ovarian cancers [ 28 ], and colorectal adenocarcinoma [ 29 ].…”

Section: Discussionmentioning

confidence: 99%

Epidemiologic characteristics of oral cancer: single-center analysis of 4097 patients from the Sun Yat-sen University Cancer Center

et al. 2016

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BackgroundOral cancer is a common type of head and neck cancers. Knowing its epidemiologic characteristics is crucial to preventing, diagnosing, and treating this cancer. This study aimed to explore the epidemiologic characteristics of oral cancer in South China.MethodsWe retrospectively analyzed data from 4097 oral cancer patients treated at the Sun Yat-sen University Cancer Center between 1960 and 2013. We compared the age of onset, sex ratio, pathologic type, and primary tumor location among three subcultural areas (Guangfu, Hakka, and Chaoshan) and between an economically developed region and a less-developed one in Guangdong.ResultsOverall, oral cancer had a male-to-female ratio of approximately 2:1, and this ratio decreased over time. Oral cancer occurred mostly in patients of 45–64 years old (54.5%), and the percentage of older patients gradually increased over time. The most common tumor location was the tongue. Squamous cell carcinoma was the predominant pathologic type. The percentage of blood type O in oral cancer patients was lower than that in the healthy population. The male-to-female ratio in the Chaoshan area was higher than that in the Guangfu and Hakka areas, whereas the age of disease onset in Guangfu was higher than that in Hakka and Chaoshan. The male-to-female ratio was lower and the age of disease onset was higher in the economically developed region than in the less-developed region.ConclusionThe incidence of oral cancer in South China presents typical characteristics to which doctors should pay attention when diagnosing and treating oral cancer patients.

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Section: Discussionmentioning

confidence: 99%

Epidemiologic characteristics of oral cancer: single-center analysis of 4097 patients from the Sun Yat-sen University Cancer Center

et al. 2016

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“…As the most widely investigated erythrocyte antigen system and straightforward accessible element in an individual's genetic makeup ( Mao et al, 2019 ), ABO blood group system is used in clinical practice extensively ( Wang et al, 2014 ; Cooling, 2015 ). After ABO blood group system was found by Karl Landsteiner in 1901, we never interrupted searching for the relationship between ABO blood group system and various diseases ( Lesky, 1973 ).…”

Section: Introductionmentioning

confidence: 99%

Association between ABO blood groups and COVID-19 infection, severity and demise: A systematic review and meta-analysis

et al. 2020

Infection, Genetics and Evolution

181

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Background and aims The COVID-19 spreads rapidly around the world which has brought a global health crisis. The pathogen of COVID-19 is SARS-COV-2, and previous studies have proposed the relationship between ABO blood group and coronavirus. Here, we aim to delve into the association between ABO blood group and COVID-19 infection, severity and demise. Methods The relevant studies were retrieved from five databases: PubMed, MedRxiv, BioRxiv,Web of Science and CNKI. Members of cases(symptomatic cases, severe cases, died cases) and controls(asymptomatic controls, non-severe controls, alive controls) were extracted from collected studies. Odds ratios (OR) and 95% confidence intervals (CI) were calculated and interpreted from extracted data. Publication bias and sensitivity analysis were also applied to confirm our discovery. Results Overall 31,100 samples were included in the analysis. Compared to other ABO blood type, an increased odds of infecting COVID-19 among individuals with A blood group (OR: 1.249, 95%CI: 1.114–1.440, P < 0.001) and a decreased odds of infecting COVID-19 among individuals with blood group O (OR: 0.699, 95%CI: 0.635–0.770, P < 0.001) were found. Besides, individuals with blood group AB seems to link a higher risk to COVID-19 severity (OR: 2.424, 95%CI: 0.934–6.294) and demise (OR: 1.348, 95%CI: 0.507–3.583). Meantime, individuals with O blood group might had lower risk to COVID-19 severity (OR: 0.748, 95%CI: 0.556–1.007), and individuals with B blood group were likely to relate a lower risk to COVID-19 demise. Conclusions The current meta-analysis suggest that blood type A might be more susceptible to infect COVID-19 while blood type O might be less susceptible to infect COVID-19; there were no correlation between ABO blood group and severity or demise of COVID-19. However, more investigation and research are warranted to clarify the relationship between COVID-19 and ABO blood type.

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Section: Introductionmentioning

confidence: 99%

“…The ABO blood group system, the most extensively investigated erythrocyte antigen system,3 is widely used in clinical practice, and influences the host susceptibility 4 5. As an easily accessible factor in an individual’s genetic makeup, ABO blood groups have been statistically and biologically associated with many chronic diseases such as vascular disease,6 coronary heart disease7 and tumorigenesis 3 4 8. For instance, by expressing on N-glycans of von Willebrand factor (VWF), ABH antigens (H antigen is the biosynthetic precursor to A and B antigens)5 impact the half-life of VWF, so VWF survival in O subjects is significantly shorter versus in non-O subjects 9–11.…”

Section: Introductionmentioning

confidence: 99%

ABO blood groups and hepatitis B virus infection: a systematic review and meta-analysis

et al. 2020

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ObjectiveHepatitis B virus (HBV) infection is a major public health problem worldwide. Several studies have reported that ABO blood groups may be associated with HBV infection. However, its association is still controversial. We performed a meta-analysis to investigate whether ABO blood groups were associated with HBV infection.DesignSystematic review and meta-analysis.Data sourcesRelevant studies available before 1 December 2019 were identified by searching PubMed, EMBASE, Web of Science, ScienceDirect and the Cochrane Library.Eligibility criteriaAll cross-sectional or cohort studies from which the data of ABO blood group distribution and HBV infection could be extracted.Data extraction and synthesisStudies were identified and extracted by two reviewers independently. Risk ratios (RRs) and 95% CIs were pooled by random-effect models to quantify this association.ResultsThirty-eight eligible articles including 241 868 HBV-infected subjects and 6 487 481 uninfected subjects were included. Overall, the risk of HBV infection had decreased by 8% in subjects with blood group B when compared with non-B blood group (RR=0.92, 95% CI 0.86 to 0.98). In the subgroup analyses, the inverse relationship between blood group B and HBV infection remained stable in higher endemic areas (HBV prevalence ≥5%), Asian people, larger sample size studies (≥2000), general population and blood donors, lower middle income group and studies published before the year 2010. Additionally, subjects with blood group O had a 12% increased risk of HBV infection (RR=1.12, 95% CI 1.01 to 1.24) in higher endemic areas. In the sensitivity analysis, the pooled risk estimates of blood group B and HBV infection were still stable.ConclusionsOur data suggested that the blood group B was associated with a lower risk of HBV infection. More research is needed to clarify the precise role of the ABO blood group in HBV infection to address the global question of HBV infection.

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ABO blood group and esophageal carcinoma risk: from a case–control study in Chinese population to meta-analysis

Abstract: Results from our case-control study and the followed meta-analysis confirmed that there was an increased risk of EC in blood group B individuals, whereas a decreased risk of EC was observed in blood group O individuals.

Cited by 18 publications

References 39 publications

Epidemiologic characteristics of oral cancer: single-center analysis of 4097 patients from the Sun Yat-sen University Cancer Center

Epidemiologic characteristics of oral cancer: single-center analysis of 4097 patients from the Sun Yat-sen University Cancer Center

Association between ABO blood groups and COVID-19 infection, severity and demise: A systematic review and meta-analysis

ABO blood groups and hepatitis B virus infection: a systematic review and meta-analysis

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