Abnormalities of short-latency somatosensory evoked potentials in parkinsonian patients

Rossini, Paolo Maria; Babiloni, Fabio; Bernardi, Giorgio; Cecchi, L.; Johnson, PB; Malentacca, A.; Stanzione, Paolo; Urbano, Antonio

doi:10.1016/0168-5597(89)90058-0

Cited by 185 publications

(78 citation statements)

References 32 publications

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“…The physiological meaning of the frontal N30 somatosensory evoked potential (SEP) is still a matter of debate. [1][2][3]5,8,10,17,32,43,44,46,51 Indirect elements for solving this problem might be found by analyzing the modifications of the N30 component that occur in response to different physiological stimuli. Cortical SEPs can be elicited by stimulation of cutaneous as well as proprioceptive afferents.…”

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confidence: 99%

Different contribution of joint and cutaneous inputs to early scalp somatosensory evoked potentials

et al. 1999

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confidence: 99%

Different contribution of joint and cutaneous inputs to early scalp somatosensory evoked potentials

et al. 1999

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“…Scalp mapping studies and recordings from patients with cerebral lesions like Huntington's disease and from focal infarctions suggested area 4 as generator (Abbruzzese et al 1990;Desmedt and Ozaki 1991;Desmedt et al 1987;Mauguiere and Desmedt 1991;Rossini et al 1989;Töpper et al 1993). In a recent study using electroencephalographic (EEG) dipole source analysis, Jung et al (2008) localized the P22 dipole source in area 4 but could not rule out area 1, which also contributed to the signal.…”

Section: Introductionmentioning

confidence: 99%

Dipole Source Analyses of Early Median Nerve SEP Components Obtained From Subdural Grid Recordings

Baumgärtner

Vogel

Ohara

et al. 2010

Journal of Neurophysiology

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Baumgärtner U, Vogel H, Ohara S, Treede RD, Lenz FA. Dipole source analyses of early median nerve SEP components obtained from subdural grid recordings. J Neurophysiol 104: 3029 -3041, 2010. First published September 22, 2010 doi:10.1152/jn.00116.2010. The median nerve N20 and P22 SEP components constitute the initial response of the primary somatosensory cortex to somatosensory stimulation of the upper extremity. Knowledge of the underlying generators is important both for basic understanding of the initial sequence of cortical activation and to identify landmarks for eloquent areas to spare in resection planning of cortex in epilepsy surgery. We now set out to localize the N20 and P22 using subdural grid recording with special emphasis on the question of the origin of P22: Brodmann area 4 versus area 1. Electroencephalographic dipole source analysis of the N20 and P22 responses obtained from subdural grids over the primary somatosensory cortex after median nerve stimulation was performed in four patients undergoing epilepsy surgery. Based on anatomical landmarks, equivalent current dipoles of N20 and P22 were localized posterior to (n ϭ 2) or on the central sulcus (n ϭ 2). In three patients, the P22 dipole was located posterior to the N20 dipole, whereas in one patient, the P22 dipole was located on the same coordinate in anterior-posterior direction. On average, P22 sources were found to be 6.6 mm posterior [and 1 mm more superficial] compared with the N20 sources. These data strongly suggest a postcentral origin of the P22 SEP component in Brodmann area 1 and render a major precentral contribution to the earliest stages of processing from the primary motor cortex less likely.

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“…In PD, tactile localization 2 and spatial acuity 3 are impaired. Deficiencies in tactile processing may relate to a loss of epidermal nerve fibers and Meissner corpuscles 4 , alterations in cortical circuitry targeted by nigro-striatal output 5 , changes in somatosensory afferent transmission 6 or mutation of the PINK1 gene 7 . In PD, tactile acuity in the time domain has been studied using temporal discrimination threshold (TDT), which refers to the minimum time interval between two sequential stimuli to be perceived as distinct.…”

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Dopamine Alters Tactile Perception in Parkinson's Disease

Nelson

Premji²,

Rai³

et al. 2012

Can. J. Neurol. Sci.

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. Contexte : Le traitement anormal de l'information somatosensitive pourrait contribuer à l'altération de la motricité observée dans la maladie de Parkinson (MP). Il a été démontré que les médicaments dopaminergiques modifient le traitement de l'information somatosensitive de telle sorte que la perception tactile en est améliorée. Dans la MP, nous ne savons pas si la séquence temporelle des stimuli tactiles est modifiée et si les médicaments dopaminergiques modifient cette perception. Méthode : La perception tactile somatosensitive a été étudiée au moyen du test de discernement de l'ordre de succession de stimuli chez des patients atteints de la MP avec et sans effet de la médication dopaminergique et chez des témoins en bonne santé appariés pour l'âge. L'évaluation du discernement de l'ordre temporel de stimuli a été effectuée au moyen de la stimulation contrôlée par ordinateur des 2e et 3e doigts de la main droite. Les sujets devaient déterminer quel stimulus était appliqué le premier. Deux tâches expérimentales ont été comparées : le discernement de l'ordre temporel sans et avec synchronisation, soit l'application au préalable d'une vibration synchrone aux les 2e et 3e doigts. Résultats : Le discernement de l'ordre temporel chez les patients atteints de la MP sans et avec l'effet des médicaments était semblable à celui des témoins. Lorsque le test de discernement de l'ordre temporel était précédé par les vibrations synchrones, l'acuité tactile chez les témoins et les patients sans l'effet de la médication était perturbée à des degrés semblables, mais cette perturbation perceptuelle due aux vibrations synchrones n'était pas présente chez les patients sous l'effet de la médication. Conclusions : Ces constatations suggèrent que, chez les patients atteints de la MP, la dopamine diminue la connectivité cortico-corticale dans l'aire somatosensitive SI, ce qui provoque des changements dans la sensibilité tactile.

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Abnormalities of short-latency somatosensory evoked potentials in parkinsonian patients

Cited by 185 publications

References 32 publications

Different contribution of joint and cutaneous inputs to early scalp somatosensory evoked potentials

Different contribution of joint and cutaneous inputs to early scalp somatosensory evoked potentials

Dipole Source Analyses of Early Median Nerve SEP Components Obtained From Subdural Grid Recordings

Dopamine Alters Tactile Perception in Parkinson's Disease

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