Abnormalities of Platelet Function in the Myeloproliferative Disorders

Cardamone, Joseph M.; Edson, J. Roger; McArthur, James R.; Jacob, Harry S.

doi:10.1001/jama.1972.03200160022007

Cited by 67 publications

(8 citation statements)

References 12 publications

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“…In accordance with this finding in the altered megakaryopoiesis of CMPD, thrombocytes originating from those giant forms should be expected to exhibit a variety of abnormalities as was detected by electron microscopy in platelets from disorders like M F or CMGM (11,12,29). The anomalies of platelet function, which may lead to the clinical findings of both haemorrhagic or thrombotic symptoms (30)(31)(32)(33) are possibly related to those ultrastructural alterations.…”

Section: Table 3 Schematic Survey With a Semi-quantitative Grading Ofsupporting

confidence: 59%

Density Distribution and Size of Megakaryocytes in Inflammatory Reactions of the Bone Marrow (Myelitis) and Chronic Myeloproliferative Diseases

Thiele

Holgado

Choritz

et al. 1983

Scandinavian Journal of Haematology

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Morphometric evaluation was performed on semi‐thin sections of core biopsies of the bone marrow and included 20 cases of each group of diseases besides control specimens. (i) Hyperergic myelitis of rheumatic origin. (ii) Chronic granulocytic leukaemia (CGL). (iii) Polycythaemia vera (P. vera). (iv) Chronic megakaryocytic‐granulocytic myelosis (CMGM). (v) Myelofibrosis or osteomyelosclerosis (MF/OMS). The following classification of megakaryopoiesis was applied: normal megakaryocytes; giant forms; microforms; intussusceptions; cytoplasmic fragments; naked nuclei. The density distribution shows an increase of megakaryocyte number in those 5 different marrow disorders, ranging from about 13/mm2 in the normal sample up to 65 cells/mm2 in MF/OMS. Microforms are most frequently encountered in CGL, whereas giant megakaryocytes, intussusceptions and many cytoplasmic fragments characterize P. vera, CMGM and MF/OMS. Our measurements suggests 3 distinct categories of bone marrow lesions with corresponding alterations of the megakaryopoiesis: (i) myelitis and CGL; (ii) P. vera; (iii) CMGM and MF/OMS.

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Section: Table 3 Schematic Survey With a Semi-quantitative Grading Ofsupporting

confidence: 59%

Density Distribution and Size of Megakaryocytes in Inflammatory Reactions of the Bone Marrow (Myelitis) and Chronic Myeloproliferative Diseases

Thiele

Holgado

Choritz

et al. 1983

Scandinavian Journal of Haematology

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“…14 Mild hemorrhage was common in our patients; as in adults, 22 this was not associated with thrombocytopenia and may have been attributable to platelet dysfunction. 25 The type of BCR-ABL transcript was investigated in 16 of the children in our study: approximately two thirds of the children had b3a2 transcripts, as previously reported in adults with CML. 26 Our data contrast with 2 previous pediatric studies in which only 4 (24%) of the total of 17 children studied had the b3a2 transcript.…”

Section: Discussionmentioning

confidence: 62%

Clinical and Biological Features at Diagnosis in 40 Children With Chronic Myeloid Leukemia

et al. 2005

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“…ADRA2A is a low-copy receptor expressed on platelets [15]. Platelets from patients with myeloproliferative neoplasms have diminished aggregation and secretion in response to epinephrine, and this condition is associated with a decreased number of ADAR2A [16,17]. The high prevalence of this abnormality in Taiwanese Chinese has not been reported in the literature.…”

Section: Discussionmentioning

confidence: 99%

Impaired responsiveness of platelets to epinephrine due to α2A adrenoreceptor deficiency in Male Chinese

Lin¹,

Lin²,

Tseng³

et al. 2015

Platelets

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Epinephrine is known as a weak, but important, agonist for platelet activation. It has been reported that the responsiveness of platelets to epinephrine was markedly impaired in 6% of Caucasians and in 16% of Japanese. The purpose of this study was to screen and characterize this abnormality in healthy Taiwanese Chinese volunteers. We used aggregometry, flow cytometry and platelet function analyzer (PFA)-100 system to assess in 50 healthy male volunteers the responsiveness of platelets to epinephrine stimulation. Using α2A adrenoceptor antagonist BRL44408 maleate competition and a [(3)H]yohimbin binding assay, we evaluated α2A adrenoceptors on platelets. The aggregation of platelets after stimulation with 10 μM of epinephrine indicated two distinct groups of study participants: 24 (48.0%) good- and 26 (52.0%) impaired-responders to epinephrine. Flow cytometric analysis of platelets after stimulated with 1 μM epinephrine showed that glycoprotein (GP) IIb/IIIa and P-selectin expression of epinephrine good- and impaired-responders were 27.1 ± 11.0% vs. 9.9 ± 5.4% (p = 0.003) and 12.2 ± 6.2% vs. 3.6 ± 3.5% (p < 0.001), respectively. The PFA-100 system showed that epinephrine-impaired-responders had a longer collagen-epinephrine induced closure time. Good-responder platelets incubated with BRL44408 maleate had an impaired response to epinephrine stimulation. [(3)H]yohimbine binding studies showed fewer α2A adrenoreceptors on the platelets of epinephrine-impaired-responders than on those of good-responders. The prevalence of impaired responsiveness to epinephrine was high and probably due to α2A adrenoreceptor deficiency in male Taiwanese Chinese.

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Abnormalities of Platelet Function in the Myeloproliferative Disorders

Cited by 67 publications

References 12 publications

Density Distribution and Size of Megakaryocytes in Inflammatory Reactions of the Bone Marrow (Myelitis) and Chronic Myeloproliferative Diseases

Density Distribution and Size of Megakaryocytes in Inflammatory Reactions of the Bone Marrow (Myelitis) and Chronic Myeloproliferative Diseases

Clinical and Biological Features at Diagnosis in 40 Children With Chronic Myeloid Leukemia

Impaired responsiveness of platelets to epinephrine due to α2A adrenoreceptor deficiency in Male Chinese

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