Abnormalities of peripheral blood system in patients with COVID-19 in Wenzhou, China

Abstract

Background: In December 2019, coronavirus disease 2019 (COVID-19) was first found in Wuhan, China and soon was reported all around the world. Methods: All confirmed cases with COVID-19 in Wenzhou from January 19 to February 20, 2020, were collected and analyzed. Of the 116 patients with COVID-19, 27 were diagnosed as severe cases. Among severe cases, 9 were treated in ICU. The data of blood routine examination were analyzed and compared among common patients (as common group), severe patients admitted to intensive care unit (as severe ICU group) and severe patients not admitted to ICU (as severe non-ICU group). The blood routine examination results were dynamically observed in the above groups after admission. Results: Patients with COVID-19 have lower counts of leucocytes, lymphocytes, eosinophils, platelets, and hemoglobin, but have higher neutrophil-lymphocyte ratio (NLR) and monocyte-lymphocyte ratio (MLR), which were compared with controls (P < 0.001). In severe ICU group, patients have the lowest count of lymphocytes, but the highest neutrophil count and NLR among the above three groups (all P values < 0.05); NLR and MLR indicators were combined for diagnostic efficacy analysis of severe COVID-19, and its area under the curve reached 0.925. The odds ratio of the delay in days to the start of the increase of eosinophil count for predicting the outcome of patients with severe COVID-19 was 2.291 after age adjusted. Conclusions: Patients with COVID-19 have abnormal peripheral blood routine examination results. Dynamic surveillance of peripheral blood system especially eosinophils is helpful in the prediction of severe COVID-19 cases.

Associations of blood essential and toxic metal(loid)s with both disease severity and mortality in patients with COVID-19: a retrospective study

“…Considering that the heavy metals in whole blood were found to be at relatively low levels in our study, which were all within the baseline range or mildly lower than the lower limit in all the patients with COVID-19, we suspected that the decrease of the circulatory heavy metals in severe patients with COVID-19 may be attributed to the abnormalities of peripheral blood system [41]. The positive correlations among arsenic, thallium and lead suggested by our results implied a similar mechanism existed for these elements.…”

The potential role of serum angiotensin-converting enzyme in the coronavirus disease 2019

“…Immune-in ammatory reaction played a key role in the progression of COVID-19 [12,18], Therefore, we performed correlation analyses to found that serum ACE was signi cantly correlated with most of immunein ammatory parameters in this study. Additionally, we performed multiple linear regression to nd only neutrophil%, age and diastolic blood pressure had negative correlations with serum ACE activity after adjusting for other confounders.…”

A Preliminary Study on Blood Lipid Profile in Patients with COVID-19

“…Previous studies have found that the development of severe COVID-19 is associated with age and underlying disease, and severe patients are likely to suffer from aberrant in ammation reaction and cytokine storm [1,3]. Consequently, some clinical characteristics, the in ammation index and cytokine levels have been used as indictors to re ect the severity of COVID-19 by us and others [4,5]. Recently, emerging evidence suggested that lipid metabolism dysregulation might promote the progression of COVID-19 as revealed by mass spectrometry (MS)-based proteomics analysis [6,7].…”