Abnormalities of lung mechanics in young asthmatic children.

Greenough, Anne; Loftus, B G; Pool, J; Price, John

doi:10.1136/thx.42.7.500

Cited by 31 publications

(14 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…14 We have, however, previously shown that functional residual capacity is raised in young asthmatic patients and that the degree of this rise is related to the severity of the asthma as judged by the amount of treatment required. 6 We have also shown that in response to nebulised salbutamol during acute asthma attacks there is a reduction in functional residual capacity and a lessening of hyperinflation, which is associated with an appreciable improvement in compliance.7 This, plus evidence from the first part of our study that clinically important changes in functional residual capacity were always associated with a similar response in peak flow rate, suggests the measurement technique can reliably detect bronchodilator response. Thus the explanation for the three children in whom a clinically important change in functional residual capacity was not shown after bronchodilator treatment seems likely to be a failure of method of treatment administration.…”

Section: Discussionsupporting

confidence: 57%

Inhaled bronchodilator treatment via the nebuhaler in young asthmatic patients.

Pool

Greenough²,

Gleeson³

et al. 1988

Archives of Disease in Childhood

Self Cite

View full text Add to dashboard Cite

SUMMARY Changes in functional residual capacity and peak flow rate were measured to assess bronchodilator response to terbutaline inhaled via a nebuhaler. In 10 children with asthma, aged 5-7 years, five breaths sufficient to operate the nebuhaler valve resulted in clinically important improvement in both the functional residual capacity and the peak flow rate. and that nebulised bronchodilator treatment in such young children can be associated with a reduction in the functional residual capacity.7In the present studies we first investigated changes in functional residual capacity and peak flow rate, after bronchodilator treatment via the nebuhaler, in children with asthma who were capable of performing both tests. Secondly, we investigated whether children with asthma who were too young to have their peak flow rate measured reliably had a similar change in functional residual capacity on nebuhaler treatment. Patients and methodsTen consecutive children (nine boys, one girl; mean age 5-8 years, range 5-3-6.9) were enrolled into the first part of the study. Twenty two consecutive preschool children (14 boys, eight girls; mean age 3*6 years, range 2-5-4.9) were enrolled into the second part of the study. All the children were attending the paediatric clinic at King's College Hospital for the treatment of perennial asthma. Asthma was diagnosed after three separate episodes of wheezing and a clinical response to oral bronchodilator treatment. All children were receiving I adrenergic stimulants, and in addition 13 were being treated with theophylline orally and one of the older children inhaled steroids.

show abstract

Section: Discussionsupporting

confidence: 57%

Inhaled bronchodilator treatment via the nebuhaler in young asthmatic patients.

Pool

Greenough²,

Gleeson³

et al. 1988

Archives of Disease in Childhood

Self Cite

View full text Add to dashboard Cite

show abstract

“…We used a 15-minute waiting period following each treatment to allow elimination of helium from the patients' lungs before taking flow directed spirometric measurements, which are not accurate in the presence of a low-density gas such as helium (1,14). Previous studies have shown that the time to washout of helium from asthmatic lungs is less than 2 minutes (15,16). Henderson and colleagues measured spirometry at 15, 30, and 45 minutes.…”

Section: Discussionmentioning

confidence: 98%

The Utility of Albuterol Nebulized with Heliox during Acute Asthma Exacerbations

Kress

Noth

Gehlbach

et al. 2002

Am J Respir Crit Care Med

View full text Add to dashboard Cite

Heliox improves lung deposition of inhaled particles when compared with air or oxygen inhalation. We studied the spirometric effects of albuterol nebulized with heliox during emergency room visits for asthma exacerbations. Forty-five patients were randomized to receive albuterol nebulized with oxygen (control) versus heliox (n = 22 control and 23 heliox subjects). At baseline, demographics, outpatient asthma medications, vital signs, oxygen saturation, and forced expiratory volume in one second were not different between the two groups. Three consecutive albuterol treatments were given to each group. The heliox group had a significantly higher heart rate after albuterol nebulization compared with the control group. Following albuterol Treatment 1, the median change in forced expiratory volume in one second was 14.6% in the control group and 32.4% in the heliox group (p = 0.007). After Treatment 2, the results were 22.7% versus 51.5%, respectively (p = 0.007). After Treatment 3, the results were 26.6% versus 65.1%, respectively (p = 0.016). We conclude that during acute asthma exacerbations, albuterol nebulized with heliox leads to a more significant improvement in spirometry when compared with albuterol nebulized with oxygen. This is likely due to the low-density gas improving albuterol deposition in the distal airways.

show abstract

“…Hyperinflation was diagnosed if the FRC was greater than 120% of that predicted for height, that is above the 95% confidence limit of the reference range [12]. The coefficient of variation of the measurements of FRC in young asthmatic children had been previously determined as 4% [6], as a consequence and in view of the limited co-operation of the patients due to their age, only a single measurement of FRC was made before or after bronchodilator. A positive response to bronchodilator administration was deemed to be a greater than or equal to 10% change in FRC, either an increase or a decrease [7].…”

Section: Methodsmentioning

confidence: 99%