Risk factors for hyperinflation in young schoolchildren born prematurely

Giffin, F.; Greenough, A; Dimitriou, Gabriel; Naik, Sandhia

doi:10.1007/s004310050574

Cited by 2 publications

(2 citation statements)

References 12 publications

(23 reference statements)

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“…Especially in children, minor amounts of edema, mucus, or inflammatory processes may markedly narrow bronchioles; this is followed by an increment in airway resistance and production of a ball-valve effect, resulting in air trapping and lung hyperexpansion (Griscom et al, 1978;Tercier, 1983). Hyperinflation has been described in premature infants (Desmond et al, 1986;Giffin et al, 1997) and cystic fibrosis children (Grum & Lynch, 1992;Cleveland et al, 1998;Desmond et al, 1986;Marchant et al, 1994;Guignon et al, 1995), in the immotile cilia syndrome (Nadel et al, 1985), in children with liver disease due to alpha-1-antitrypsin deficiency (Hird et al, 1991), in bronchopulmonar y dysplasia (Breysem et al, 1997), in infants with large left-to-right shunts (Markowitz et al, 1988), in childhood pneumonia hyperinflation-diagnosed by chest x-ray before age 5 yr-is associated with accelerated radiographic deterioration over time (Cleveland et al, 1998). In adults, chronic overdistention is associated with a reduction in the elastic properties of the lung and can lead to structural abnormalities (Gold et al, 1967).…”

Section: Discussionmentioning

confidence: 99%

EXPOSURE TO AIR POLLUTION IS ASSOCIATED WITH LUNG HYPERINFLATION IN HEALTHY CHILDREN AND ADOLESCENTS IN SOUTHWEST MEXICO CITY: A Pilot Study

Calderón‐Garcidueñas

Mora-Tiscareño

Chung

et al. 2000

Inhalation Toxicology

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Air pollution produces adverse health effects. The consequences of lifelong daily exposures to atmospheric pollutants upon the respiratory apparatus of healthy children are of considerable clinical importance. We investigated the association between exposure to a highly polluted urban environment with a complex mixture of air pollutants-ozone and particulate matter the predominant ones-and chest x-ray abnormalities in 59 healthy Mexican children who are lifelong residents of Southwest Metropolitan Mexico City (SWMMC), with a negative history of tobacco exposure and respiratory illnesses. Their clinical results and x-ray findings were compared to those of 19 Mexican control children, residents of a low-pollution area, with a similar negative history of tobacco exposure and respiratory illnesses. Ozone concentrations in SWMMC exceeded the U.S. Environmental Protection Agency (U.S. EPA) National Ambient Air Quality Standard (NAAQS) for O(3): 0.08 ppm as 1-h maximal concentration, not to be exceeded more than 4 times a year, on 71% of days in 1986 and 95% in 1997, with values as high as 0.48 ppm. Ozone maximal peaks are usually recorded between 2 and 5 pm coinciding with children's outdoor physical activities. Children in the control group reported no upper or lower respiratory symptomatology. Every SWMMC child complained of upper and/or lower respiratory symptoms, including epistaxis, nasal dryness and crusting, cough, shortness of breath, and chest discomfort. Children aged 7-13 yr had the most symptomatology, while 5- to 6-year olds and adolescents with the lowest number of statistically significant outdoor exposure hours had less respiratory symptoms. Bilateral symmetric mild lung hyperinflation was significantly associated with exposure to the SWMMC atmosphere (p = .0004). Chronic and sustained inhalation of a complex mixture of air pollutants, including ozone and particulate matter (PM), is associated with lung hyperinflation, suggestive of small airway disease, in a population of clinically healthy children and adolescents. Small airways are a target of air pollutants in SWMMC children, with ozone and PM being most likely responsible, based on experimental animal, controlled-chamber, and epidemiological data available. Our main concern is the potential likelihood for the development of chronic lung disease in this highly exposed population.

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Section: Discussionmentioning

confidence: 99%

EXPOSURE TO AIR POLLUTION IS ASSOCIATED WITH LUNG HYPERINFLATION IN HEALTHY CHILDREN AND ADOLESCENTS IN SOUTHWEST MEXICO CITY: A Pilot Study

Calderón‐Garcidueñas

Mora-Tiscareño

Chung

et al. 2000

Inhalation Toxicology

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“…Infants who had been cared for in the restricted use centres, although discharged at an older age, however, had significantly more GP and community care contacts. One explanation is that greater initial disease severity might have predisposed the infants in the restricted centres to higher chronic respiratory morbidity [2], hence their significantly greater number of GP and community care contacts. An alternative explanation is that a higher proportion received postnatal dexamethasone.…”

Section: Discussionmentioning

confidence: 99%

High versus restricted use of home oxygen therapy, health care utilisation and the cost of care in chronic lung disease infants

Greenough

Alexander

Burgess

et al. 2004

European Journal of Pediatrics

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Risk factors for hyperinflation in young schoolchildren born prematurely

Abstract: Hyperinflation in young children born prematurely reflects current symptom status and not adverse neonatal events.

Cited by 2 publications

References 12 publications

EXPOSURE TO AIR POLLUTION IS ASSOCIATED WITH LUNG HYPERINFLATION IN HEALTHY CHILDREN AND ADOLESCENTS IN SOUTHWEST MEXICO CITY: A Pilot Study

EXPOSURE TO AIR POLLUTION IS ASSOCIATED WITH LUNG HYPERINFLATION IN HEALTHY CHILDREN AND ADOLESCENTS IN SOUTHWEST MEXICO CITY: A Pilot Study

High versus restricted use of home oxygen therapy, health care utilisation and the cost of care in chronic lung disease infants

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