Abnormalities of Erythrocyte Deformability and Platelet Aggregation in Insulin-Dependent Diabetics Corrected by Insulin in Vivo and in Vitro

Low O2-induced ATP release from erythrocytes of humans with type 2 diabetes is restored by physiological ratios of C-peptide and insulin

“…Humans with type 1 diabetes are reported to have reduced erythrocyte deformability and increased blood viscosity attributed to a reduction in erythrocyte Na ϩ -K ϩ -ATPase activity (10,25,47). Interestingly, C-peptide has been reported to stimulate Na ϩ -K ϩ -ATPase activity in these erythrocytes, resulting in increased deformability (12,16,27).…”

Real and artefactual erythrocyte swelling in hyperglycaemia

“…A reduced erythrocyte deformability has been observed in diabetes mellitus and assumed to play a role in the development of diabetic microangiopathy [14][15][16][17]. Deformability was determined by filtration through standard size pores [18] in most of these studies.…”

Measurement Techniques for Red Blood Cell Deformability: Recent Advances

“…RBC deformabiltiy can be calculated from either the flow time or the volume of blood filteres in a certain amount of time (~1 min). Since the filteration test requires for a relatively simple instrument and provides clinically relevant results with high reproducibility, it has been widely used in various studies related to RBC deformability, including the effects of diabetes (Juhan, Buonocore et al,1982), spesis (Baskurt, Gelmont et al,1998), sickle cell disease (JANDL, SIMMONS et al,1961), and oxygen radical (Srour, Bilto et al,2000).…”