Abnormalities of Antibody Production After Thermal Injury

Wood, J. Jeremy

doi:10.1001/archsurg.1986.01400010122017

Cited by 37 publications

(2 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There can be primary, secondary, or opportunistic HSV infections due to viral reactivation following reduced immunity in burn patients [ 54 ]. It not only impairs the healing process, prolonging the recovery time, but also causes a reduction in the number of T-lymphocytes, down-regulation of Toll-like receptor-mediated nuclear factor-κB expression, and abnormal production of interleukin (IL)-2, cytokines, and antibodies [ 55 , 56 ].…”

Section: Pathogens Of Burn Wound Infectionsmentioning

confidence: 99%

Microbial infections in burn patients

Roy,

Mukherjee,

Kundu

et al. 2024

ACC

View full text Add to dashboard Cite

Polymicrobial infections are the leading causes of complications incurred from injuries that burn patients develop. Such patients admitted to the hospital have a high risk of developing hospital-acquired infections, with longer patient stays leading to increased chances of acquiring such drug-resistant infections. Acinetobacter baumannii, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Proteus mirabilis are the most common multidrug-resistant (MDR) Gram-negative bacteria identified in burn wound infections (BWIs). BWIs caused by viruses, like Herpes Simplex and Varicella Zoster, and fungi-like Candida spp. appear to occur occasionally. However, the preponderance of infection by opportunistic pathogens is very high in burn patients. Variations in the causative agents of BWIs are due to differences in geographic location and infection control measures. Overall, burn injuries are characterized by elevated serum cytokine levels, systemic immune response, and immunosuppression. Hence, early detection and treatment can accelerate the wound-healing process and reduce the risk of further infections at the site of injury. A multidisciplinary collaboration between burn surgeons and infectious disease specialists is also needed to properly monitor antibiotic resistance in BWI pathogens, help check the super-spread of MDR pathogens, and improve treatment outcomes as a result.

show abstract

Section: Pathogens Of Burn Wound Infectionsmentioning

confidence: 99%

Microbial infections in burn patients

Roy,

Mukherjee,

Kundu

et al. 2024

ACC

View full text Add to dashboard Cite

show abstract

“…Subsequently, the percentage of potential bacterial infections is also significantly increased in such patients [34]. The abovementioned immune-related alterations also include a decreased number of T lymphocytes and lowered lymphocytic responsiveness to mitogenic and HSV antigenic stimuli, as well as a decreased release of interleukin-2 (IL-2), and abnormal antibody production [35].…”

Section: Hsv Infection and Burn Woundsmentioning

confidence: 99%

Viral Infections in Burn Patients: A State-Of-The-Art Review

Baj

Korona-Głowniak

Buszewicz

et al. 2020

Viruses

View full text Add to dashboard Cite

Infections that are triggered by the accompanying immunosuppression in patients with burn wounds are very common regardless of age. Among burn patients, the most frequently diagnosed infections include the bacterial ones primarily caused by Pseudomonas aeruginosa or Klebsiella pneumonia, as well as fungal infections with the etiology of Candida spp. or Aspergillus spp. Besides, burn wounds are highly susceptible to viral infections mainly due to the impaired immune responses and defective functions of the immune cells within the wound microenvironment. The most prevalent viruses that invade burn wounds include herpes simplex virus (HSV), cytomegalovirus (CMV), human papilloma virus (HPV), and varicella zoster virus (VZV). Likewise, less prevalent infections such as those caused by the orf virus or Epstein–Barr Virus (EBV) might also occur in immunosuppressed burn patients. Viral infections result in increased morbidity and mortality rates in severely burned patients. Additionally, a positive correlation between the hospitalization duration and the severity of the viral infection has been demonstrated. Viral infections trigger the occurrence of various complications, ranging from mild symptoms to even fatal incidents. Accurate detection of viral infection is of great clinical importance because of the possibility for a quicker introduction of proper treatment therapy and shortening of hospitalization time. The aim of this paper is to provide a comprehensive review of the literature and summarize the findings regarding the most common viral infections in immunosuppressed burn patients.

show abstract

Inhibition of Early Events in the Human T-Lymphocyte Response to Mitogens and Alloantigens by Hydrogen Peroxide

Freed¹

1987

Arch Surg

View full text Add to dashboard Cite

Abnormalities of Antibody Production After Thermal Injury

Cited by 37 publications

References 25 publications

Microbial infections in burn patients

Microbial infections in burn patients

Viral Infections in Burn Patients: A State-Of-The-Art Review

Inhibition of Early Events in the Human T-Lymphocyte Response to Mitogens and Alloantigens by Hydrogen Peroxide

Contact Info

Product

Resources

About