Abnormalities in the thalamo-cortical network in patients with functional constipation

Liu, Lei; Hu, Chunxin; Hu, Yang; Zhang, Wenchao; Zhang, Zhida; Ding, Yueyan; Wang, Yuanyuan; Deneen, Karen M. von; Sun, Lu; Wang, Huaning; Duan, Shijun; Mao, Kuanrong; Wang, Fan; Cui, Guangbin; Liu, Jixin; Nie, Yongzhan; Zhang, Yi

doi:10.1007/s11682-020-00273-y

Cited by 23 publications

(34 citation statements)

References 90 publications

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“…These results suggested that patients with FC exhibited small-world network architecture in both cerebral functional and structural networks. However, this study did not find significant group differences in small-world indexes (C p , L p , γ, λ, and σ) and network efficiency (E glob and E loc ) in the WM networks, although some study found that the γ and σ values of patients with FC were significantly lower than those of HS in the functional networks (19). The current results indicated that no altered capacities of information transformation were observed in the global level of the WM networks.…”

Section: Discussioncontrasting

confidence: 86%

“…As a central relay region, the thalamus relays visceral inputs to the cortical components of the "visceral sensory neuromatrix" (64)(65)(66) and participates in the gastrointestinal sensory modulation. The functional and structural alterations in the caudate and thalamus were found in multiple FGIDs including irritable bowel syndrome (67,68), functional dyspepsia (69,70), and FC (19). In this study, the decreased nodal characteristics in the caudate and thalamus indicated the disrupted and less interregional information flows of the visceral sensory, which would have an impact on the processing of the visceral sensory in patients with FC.…”

Section: The Decreased Nodal Characteristics In Patients With Fcmentioning

confidence: 54%

“…It has both high local and global efficiencies, which meant an optimal balance between the segregation and integration of information processing procedures (38,50,51). A study also showed that the functional networks in patients with FC manifested small-world network architecture (19). These results suggested that patients with FC exhibited small-world network architecture in both cerebral functional and structural networks.…”

Section: Discussionmentioning

confidence: 96%

“…Multiple functional magnetic resonance imaging (fMRI) studies with different data analysis methods showed that patients with FC manifested significant brain activity alterations in the anterior insula and orbitofrontal cortex (OFC) (17), a stronger effective connectivity from the OFC and dorsal anterior cingulate cortex and a weaker effective connectivity from the supplementary motor area and precentral gyrus (18), and abnormal functional connectivity in the thalamocortical network. These results demonstrated that the functional abnormalities of patients with FC were not only in the brain regions but also in the functional networks (19). Additionally, using structural magnetic resonance imaging (sMRI), altered white matter (WM) microstructure (20) and cortical morphometry (21) in patients with FC have been identified.…”

Section: Introductionmentioning

confidence: 85%

“…Similar to OFC, functional and structural alterations of the ACG were found in FC neuroimaging studies. For example, patients with FC showed significantly increased activity in the ACG with the amplitude of low-frequency fluctuation analysis (18) and altered nodal degree and efficiency in the ACG with functional network analysis compared with HS (19). Furthermore, the stronger functional effective connectivity of the OFC and ACG was detected among patients with FC, which is related to the abnormal regulating visceral response (18).…”

Section: The Increased Nodal Characteristics In Patients With Fcmentioning

confidence: 95%

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Alterations of White Matter Network Properties in Patients With Functional Constipation

Yin

et al. 2021

Front. Neurol.

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Background: The abnormalities in brain function and structure of patients with functional constipation (FC) have been identified using multiple neuroimaging studies and have confirmed the abnormal processing of visceral sensation at the level of the central nervous system (CNS) as an important reason for FC. As an important basis for central information transfer, the role of the white matter (WM) networks in the pathophysiology of FC has not been investigated. This study aimed to explore the topological organization of WM networks in patients with FC and its correlation with clinical variables.Methods and Analysis: In this study, 70 patients with FC and 45 age- and gender-matched healthy subjects (HS) were recruited. Diffusion tensor imaging (DTI) data and clinical variables were acquired from each participant. WM networks were constructed using the deterministic fiber tracking approach, and the global and nodal properties of the WM networks were compared using graph theory analysis between patients with FC and HS. The relationship between the representative nodal characteristics–nodal betweenness and clinical parameters was assessed using partial correlation analysis.Results: Patients with FC showed increased nodal characteristics in the left superior frontal gyrus (orbital part), right middle frontal gyrus (orbital part), and right anterior cingulate and paracingulate (P < 0.05, corrected for false discovery rate) and decreased nodal characteristics in the left caudate and left thalamus (P < 0.05, corrected for false discovery rate) compared with HS. The duration of FC was negatively correlated with the nodal betweenness of the left thalamus (r = −0.354, P = 0.04, corrected for false discovery rate).Conclusion: The results indicated the alternations in WM networks of patients with FC and suggested the abnormal visceral sensation processing in the CNS from the perspective of large-scale brain WM network.

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Section: Discussioncontrasting

confidence: 86%

Section: The Decreased Nodal Characteristics In Patients With Fcmentioning

confidence: 54%

Section: Discussionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 85%

Section: The Increased Nodal Characteristics In Patients With Fcmentioning

confidence: 95%

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Alterations of White Matter Network Properties in Patients With Functional Constipation

Yin

et al. 2021

Front. Neurol.

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Changes in the anterior cingulate cortex in Crohn’s disease: A neuroimaging perspective

Kong

Gao

et al. 2020

Brain and Behavior

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Aberrant functional brain network dynamics in patients with functional constipation

Yin

et al. 2021

Human Brain Mapping

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The aberrant static functional connectivity of brain network has been widely investigated in patients with functional constipation (FCon). However, the dynamics of brain functional connectivity in FCon patients remained unknown. This study aimed to detect the brain dynamics of functional connectivity states and network topological organizations of FCon patients and investigate the correlations of the aberrant brain dynamics with symptom severity. Eighty-three FCon patients and 80 healthy subjects (HS) were included in data analysis. The spatial group independent component analysis, sliding-window approach, k-means clustering, and graph-theoretic analysis were applied to investigate the dynamic temporal properties and coupling patterns of functional connectivity states, as well as the time-variation of network topological organizations in FCon patients. Four reoccurring functional connectivity states were identified in k-means clustering analysis. Compared to HS, FCon patients manifested the lower occurrence rate and mean dwell time in the state with a complex connection between default mode network and cognitive control network, as well as the aberrant anterior insula-cortical coupling patterns in this state, which were significantly correlated with the symptom severity. The graph-theoretic analysis demonstrated that FCon patients had higher sample entropy at the nodal efficiency of anterior insula than HS. The current findings provided dynamic perspectives for Tao Yin, Zhaoxuan He, and Peihong Ma contributed equally to this study and are also the co-first authors.

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Abnormalities in the thalamo-cortical network in patients with functional constipation

Cited by 23 publications

References 90 publications

Alterations of White Matter Network Properties in Patients With Functional Constipation

Alterations of White Matter Network Properties in Patients With Functional Constipation

Changes in the anterior cingulate cortex in Crohn’s disease: A neuroimaging perspective

Aberrant functional brain network dynamics in patients with functional constipation

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