Changes in the anterior cingulate cortex in Crohn’s disease: A neuroimaging perspective

Kong, Ning; Gao, Chen; Xu, Maosheng; Gao, Xuning

doi:10.1002/brb3.2003

Cited by 16 publications

(13 citation statements)

References 80 publications

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“…For example, Wang and colleagues found that gut microbiota alteration impaired DMN topological properties (including clustering coefficient, local efficiency, Gamma , and Sigma ) by increasing systemic inflammation in end-stage renal disease patients ( Wang et al, 2019 ). Certainly, the occurrence of some diseases is closely correlated with gut microbial alteration, and these diseases show changes in topological parameters of the functional network at the same time, which might provide indirect evidence that gut microbiota can influence the topological properties of functional networks, such as in IBS ( Kano et al, 2020 ) and Crohn’s disease ( Kong N. et al, 2021 ). In this study, we found that some nodal properties of the brain functional network were related to the diversity and enterotypes of the gut microbiota in healthy young adults.…”

Section: Discussionmentioning

confidence: 99%

Brain Network Topology and Structural–Functional Connectivity Coupling Mediate the Association Between Gut Microbiota and Cognition

Zhang

et al. 2022

Front. Neurosci.

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Increasing evidence indicates that gut microbiota can influence cognition via the gut–brain axis, and brain networks play a critical role during the process. However, little is known about how brain network topology and structural–functional connectivity (SC–FC) coupling contribute to gut microbiota-related cognition. Fecal samples were collected from 157 healthy young adults, and 16S amplicon sequencing was used to assess gut diversity and enterotypes. Topological properties of brain structural and functional networks were acquired by diffusion tensor imaging (DTI) and resting-state functional magnetic resonance imaging (fMRI data), and SC–FC coupling was further calculated. 3-Back, digit span, and Go/No-Go tasks were employed to assess cognition. Then, we tested for potential associations between gut microbiota, complex brain networks, and cognition. The results showed that gut microbiota could affect the global and regional topological properties of structural networks as well as node properties of functional networks. It is worthy of note that causal mediation analysis further validated that gut microbial diversity and enterotypes indirectly influence cognitive performance by mediating the small-worldness (Gamma and Sigma) of structural networks and some nodal metrics of functional networks (mainly distributed in the cingulate gyri and temporal lobe). Moreover, gut microbes could affect the degree of SC–FC coupling in the inferior occipital gyrus, fusiform gyrus, and medial superior frontal gyrus, which in turn influence cognition. Our findings revealed novel insights, which are essential to provide the foundation for previously unexplored network mechanisms in understanding cognitive impairment, particularly with respect to how brain connectivity participates in the complex crosstalk between gut microbiota and cognition.

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Section: Discussionmentioning

confidence: 99%

Brain Network Topology and Structural–Functional Connectivity Coupling Mediate the Association Between Gut Microbiota and Cognition

Zhang

et al. 2022

Front. Neurosci.

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“…Recent MR spectroscopy study showed that patients with CD experiencing abdominal pain have an imbalance in glutamate and γ‐aminobutyric acid levels in the anterior cingulate cortex, whereas another CD study showed that lower grey matter volumes in the anterior cingulate cortex correlated strongly with higher pain scores 76 . In terms of function, connectivity within the default mode network was increased in the anterior cingulate cortex and decreased between the anterior cingulate cortex and amygdala, which may be attributed to negative emotions and changes in gut microbiota 77 . Collectively, multidimensional brain MRI data suggest that the anterior cingulate cortex is associated with pain and depression in patients with CD, indicating that the anterior cingulate cortex might be a potential neural alternative for managing the progression of CD.…”

Section: Role Of Brain Mr Imaging In Gut‐brain Axis Research In CDmentioning

confidence: 99%

“… 76 In terms of function, connectivity within the default mode network was increased in the anterior cingulate cortex and decreased between the anterior cingulate cortex and amygdala, which may be attributed to negative emotions and changes in gut microbiota. 77 Collectively, multidimensional brain MRI data suggest that the anterior cingulate cortex is associated with pain and depression in patients with CD, indicating that the anterior cingulate cortex might be a potential neural alternative for managing the progression of CD.…”

Section: Role Of Brain Mr Imaging In Gut‐brain Axis Research In CDmentioning

confidence: 99%

Inflammatory bowel disease cross‐sectional imaging: What's new?

et al. 2022

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Cross‐sectional imaging—ultrasonography, computed tomography enterography, and magnetic resonance enterography—is a routine and indispensable tool for patients with Crohn's disease (CD) that helps to detect or monitor disease characteristics before, during, and after CD treatment. New emerging radiological technologies may have further clinical applications in the management of CD. In this review article, we focus on the latest developments in cross‐sectional imaging in CD research, including its role in intra‐ and extra‐luminal lesion detection, intestinal inflammation and fibrosis grading, therapeutic response assessment and outcome prediction, postoperative recurrence detection and prediction, and the gut‐brain axis.

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“…Interestingly, the anterior cingulate cortex (ACC), part of the autonomic forebrain loop, functioning as a relay hub and transmitting various input signals after evaluating requirements from other regions to guide adaptive behaviors, is particularly sensitive to cytokines ( 158 , 159 ). Notably, both depression and CD are inflammation-related disorders and dysfunction of the ACC was reported in depression and CD ( 160 , 161 ). Further, a recent study from Xu group found that patients with CD who were in the active phase exhibited higher amplitude of low frequency fluctuation (ALFF) in the left ACC and a positive correlation between mWavelet-ALFF values of the ACC and Hospital Anxiety and Depression Scale-depression scores in CD patients ( 162 ).…”

Section: Vagal Tone Gut Permeability and Inflammation And Depressionmentioning

confidence: 99%

Recognizing the role of the vagus nerve in depression from microbiota-gut brain axis

Tan¹,

Yan

et al. 2022

Front. Neurol.

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Depression is a worldwide disease causing severe disability, morbidity, and mortality. Despite abundant studies, the precise mechanisms underlying the pathophysiology of depression remain elusive. Recently, cumulate research suggests that a disturbance of microbiota-gut-brain axis may play a vital role in the etiology of depression while correcting this disturbance could alleviate depression symptoms. The vagus nerve, linking brain and gut through its afferent and efferent branches, is a critical route in the bidirectional communication of this axis. Directly or indirectly, the vagus afferent fibers can sense and relay gut microbiota signals to the brain and induce brain disorders including depression. Also, brain changes in response to stress may result in gut hyperpermeability and inflammation mediating by the vagal efferents, which may be detrimental to depression. Notably, vagus nerve stimulation owns an anti-inflammatory effect and was proved for depression treatment. Nevertheless, depression was accompanied by a low vagal tone, which may derive from response to stress and contribute to pathogenesis of depression. In this review, we aim to explore the role of the vagus nerve in depression from the perspective of the microbiota-gut-brain axis, highlighting the relationship among the vagal tone, the gut hyperpermeability, inflammation, and depression.

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Changes in the anterior cingulate cortex in Crohn’s disease: A neuroimaging perspective

Abstract: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 16 publications

References 80 publications

Brain Network Topology and Structural–Functional Connectivity Coupling Mediate the Association Between Gut Microbiota and Cognition

Brain Network Topology and Structural–Functional Connectivity Coupling Mediate the Association Between Gut Microbiota and Cognition

Inflammatory bowel disease cross‐sectional imaging: What's new?

Recognizing the role of the vagus nerve in depression from microbiota-gut brain axis

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