Abstract:Evidence from the literature is contentious about the impact of polycystic ovary syndrome (PCOS) on the skeleton, suggesting a possible negative role of this condition on non-obese women. We investigated this hypothesis employing a well-characterized testosterone propionate (TP) rodent model of PCOS to address the consequences of androgenization on bone microarchitecture, histology, and mechanical strength. For this study, Wistar rats (n= 38) were divided in 4 groups: 1) “Control OVX” (single dose of corn oil … Show more
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