Abnormal ventilatory control in Parkinson's disease—Further evidence for non-motor dysfunction

Seccombe, Leigh M.; Giddings, Hugh; Rogers, Peter G.; Corbett, Alastair; Hayes, Michael; Peters, Matthew J.; Veitch, Elizabeth M.

doi:10.1016/j.resp.2011.09.012

Cited by 77 publications

(84 citation statements)

References 19 publications

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“…Table 2 reinforces such results, indicating substantially lower results for subjects in G2 in relation to the others. This finding corroborates those found by Seccombe et al 20 and reinforces the spirometry reports, which indicate an association between the decline in pulmonary function with PD and physical inactivity.…”

Section: Discussionsupporting

confidence: 93%

Pacientes com doença de Parkinson sob assistência fisioterapêutica apresentam parâmetros pulmonares melhores do que controles sedentários

et al. 2016

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| The aim of this study was to investigate the pulmonary parameters (spirometry and impulse oscillometry) of patients with Parkinson disease (PD) and healthy control peers, comparing the values of the subjects that were participating or not on a physiotherapeutic assistance program. Thirty-seven subjects were divided into four groups: two were formed by patients with PD (practitioners and non-practitioners of a physiotherapeutic protocol performed twice a week during 6 months) and the other two groups were formed by control peers (practitioners and non-practitioners of the same therapeutic protocol). The subjects underwent evaluation of chest cirtometry, spirometry and impulse oscillometry, being all the PD patients evaluated on the "off" state of their anti-PD medication. Data analysis occurred through the use of the non-parametric test of Kruskal-Wallis, with pairwise comparisons being done with Dunett T3 tests. Significance was set at 5%. Regarding

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Section: Discussionsupporting

confidence: 93%

Pacientes com doença de Parkinson sob assistência fisioterapêutica apresentam parâmetros pulmonares melhores do que controles sedentários

et al. 2016

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“…Although Neder et al, 28 analyzing the same age range as the present study, found normality of P Imax values of Ϫ92. 8 29 Because of the male biotype, it is common for the reference values for P Imax and P Emax to be slightly higher in men than in women, although this does not necessarily indicate a significant difference between the sexes. The present study corroborates this fact, apart from the values of the Parkinson's group, which were shown to be perceptibly lower in women compared with men.…”

Section: Respiratory Strength In Parkinson's and Alzheimer's Diseasementioning

confidence: 99%

“…7 In addition to this, the illness can lead to obstruction of the upper airways, restrictive defects, and inadequate ventilatory control. 8 On the other hand, AD is characterized as one of the most prevalent causes of dementia in the world. It originally affects the basal nucleus of Meynert and is defined post mortem by the presence of amyloid plaques and neurofibrillary tangles.…”

Section: Introductionmentioning

confidence: 99%

Neurodegenerative Disorders Increase Decline in Respiratory Muscle Strength in Older Adults

et al. 2014

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, and control (n ‫؍‬ 25). The participants underwent anthropometric and cirtometric measurements associated with maximal respiratory pressures. We analyzed data using descriptive (mean and SD) and inferential statistics (1-way analysis of variance, Student t test, and Scheffé post hoc) with a level of significance of 5% (P < .05) and a CI of 95%. RESULTS: Although the anthropometric and cirtometric variables indicated similarity of values between groups (P > .05), the maximal inspiratory and expiratory pressures were considerably lower in the subjects with PD and AD (P < .01). CONCLUSIONS: The control of the anthropometric and cirtometric variables of the subjects indicates that RMS is affected by the aging process, and its decline increases in neurodegenerative conditions. This fact represents a serious risk for the development of atelectasis and other pneumo-functional complications, which must be considered in proposing of future therapies.

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“…Isto pode acontecer em decorrência de uma série de fatores relacionados à sintomatologia clínica motora e/ou não motora apresentada nesta patologia. (8,(10)(11)(12)(13) É possível inferir que o quadro propiciado por esta disfunção tende a gerar distúrbios de ordem estrutural com impacto funcional significativo.…”

Section: Discussionunclassified

“…Esses dados corroboram com outro estudo, onde 68% dos avaliados apresentaram valores abaixo do limite inferior da normalidade para PImáx e 79% para PEmáx. (12) Os resultados de uma pesquisa semelhante indicaram que a PImáx e a PEmáx estavam reduzidas em pessoas com DP quando comparadas a um grupo controle. (13) Estes parâmetros se associam negativamente com a gravidade de sintomas respiratórios e a com a progressão da doença.…”

Section: Discussionunclassified

Alterações Funcionais Respiratórias Na Doença De Parkinson

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et al. 2016

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ResumoIntrodução: Caracterizada como uma patologia crônica, neurodegenerativa e progressiva, a Doença de Parkinson (DP) está relacionada a disfunções monoaminérgicas múltiplas, incluindo déficits dos sistemas dopaminérgicos, colinérgicos, serotoninérgicos e noradrenérgicos. Sintomas motores clás-sicos como a rigidez, bradicinesia, tremor em repouso e instabilidade postural são presentes nesta condição. Derivada desta tétrade motora, as alterações posturais, a rigidez e a bradicinesia levam à redução da força muscular respiratória, modificam a biomecânica da caixa torácica causando déficits na expansão pulmonar, podendo ainda, repercutir nos volumes e capacidades pulmonares. Objetivo: Sistematizar o conhecimento acerca das alterações funcionais respiratórias presentes na doença de Parkinson. Metodologia: Trata-se de um estudo de Revisão de Literatura. As bases de dados pesquisadas foram Bireme, Scielo e PubMed, e foram incluídos artigos originais, publicados a partir do ano de 2000, que avaliaram a função pulmonar com medidas da manobra de capacidade vital forçada (espirometria), pico de fluxo de tosse, força muscular respiratória e a mobilidade torácica. Foram excluídos artigos que avaliaram a função pulmonar com outros desfechos e aqueles que não foram disponibilizados na íntegra. Resultados: Foram encontrados 45 artigos, e após a aplicação dos critérios de inclusão e exclusão, foram selecionados 16 estudos. Considerações Finais: Esta revisão de literatura sugere que pessoas com Parkinson apresentam redução da mobilidade torácica, do pico de fluxo de tosse, da força muscular respiratória e de volumes e capacidades pulmonares, implicando no comprometimento da funcionalidade destes indivíduos. Introduction: Parkinson's Disease (PD) is a chronic progressive neurodegenerative pathology related to a multiple monoaminergic dysfunctions, including dopaminergic, cholinergic, serotoninergic and noradrenergic systems deficits. Classic motor system deficits like stiffness, bradikynesia, postural instability and tremors are present in such conditions. The motor system deficits lead to a reduction in respiratory muscle function and the lung mechanics and respiratory function are then modified. Objective: To summarize the PD impact on respiratory function knowledge through a systematized literature review. Methods: This is a literature review study. Bibliographic search was conducted in Bireme, Scielo and PubMed databases. Original papers published from January first, 2000 to June first 2016 were selected. Papers with pulmonary function with measurement of forced vital capacity, cough peak flow, respiratory muscle strength and thoracic mobility were included. Papers with other outcomes and those whose authors had not acess to full text versions were excluded. Results: Forty-five papers were initially selected, being 29 excluded. At the end, sixteen papers entered in the study, and two of them evaluated thoracic mobility, 11 evaluated cogh peak flow and forced vital capacity, and four evaluated respiratory muscle strength. Fi...

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Abnormal ventilatory control in Parkinson's disease—Further evidence for non-motor dysfunction

Cited by 77 publications

References 19 publications

Pacientes com doença de Parkinson sob assistência fisioterapêutica apresentam parâmetros pulmonares melhores do que controles sedentários

Pacientes com doença de Parkinson sob assistência fisioterapêutica apresentam parâmetros pulmonares melhores do que controles sedentários

Neurodegenerative Disorders Increase Decline in Respiratory Muscle Strength in Older Adults

Alterações Funcionais Respiratórias Na Doença De Parkinson

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