Abnormal uterine bleeding as a presentation of metastatic breast disease in a patient with advanced breast cancer

Karvouni, Evangelia; Papakonstantinou, Katerina; Dimopoulou, Catherine; Kairi-Vassilatou, E; Hasiakos, D; Gennatas, Constantine; Kondi-Paphiti, A.

doi:10.1007/s00404-008-0665-9

Cited by 23 publications

(17 citation statements)

References 9 publications

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“…The extragenital tumors most often metastasizing to the uterine corpus are breast carcinoma (47.3%), stomach carcinoma (29%), and melanoma (5.4%) [1]. Lobular infiltrating carcinoma of the breast is the histological type that most frequently metastasizes to the uterus [2,4,6].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Breast Cancer Masquerades as an Endometrial Cancer

Akinpeloye¹

2017

Obstet Gynecol Cases Rev

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Section: Discussionmentioning

confidence: 99%

“…Extragenital carcinomas secondarily involving the uterus are very rare [1]. There are few case reports available in the English language literature on this seldom seen occurrence.…”

Section: Introductionmentioning

confidence: 99%

Breast Cancer Masquerades as an Endometrial Cancer

Akinpeloye¹

2017

Obstet Gynecol Cases Rev

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“…Breast is the most common primary carcinoma seen in uterus followed by, stomach, cutaneous malonoma, lung, colon, pancreas and kidney [1][2][3]. Endometrial involvement, when present, can be a component of diffuse metastasis of a disseminated cancer [11,[14][15][16] and endometrial involvement is usually diffuse sparing the glands [1]. But isolated metastatic foci can also be seen in endometrial polyps, but these are as case reports in the literature and summarized in the table 1.…”

Section: Discussionmentioning

confidence: 99%

Breast carcinoma metastasis to endometrial polyp (Case report and literature review)

Türkmen¹,

Başsüllü²,

Yaşar³

et al. 2013

CMJ

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Metastasis to female genital tract are most commonly seen in the ovaries and it is very rare for uterus to have metastasis from extragenital organs. Metastatic carcinoma in an endometrial polyp is exceptional and presented as case reports in the literature. The presented case was a 52 year old woman, having metastatic breast carcinoma of invasive ductal type. She admitted to the gynecology department, with the complaint of postmenapausal bleeding. The pathological examination revealed a hyperplastic endometrial polyp, having a focus of epiteloid cellular infiltration in the stroma. The immunohistochemical staining showed these cells to be CD 10 negative, Pancytkeratin and GCDFP-15 positive. Pathological diagnosis was hyperplastic polyp, with focal carcinoma infiltration (compatible with breast carcinoma). The curettage specimens of the patients being followed for breast carcinoma is frequently seen in the daily routine of the pathology. The probability of metastatic disease must be kept in mind and the whole curretage materials must be evaluated. The pathological examination must be carefully made for the exclusion of a metastatic carcinoma. Keywords: Endometrium, metastasis, breast carcinoma, endometrial polyp Özet Kadın genital sistemde metastazlar en sık overlerde görülür ve uterus için ekstragenital organlar dışından metastaz alımı çok nadirdir. Endometrial polipe metastaz ististani bir durum olup, literatürde olgu sunumları şeklinde yer almaktadır. Sunulan olgu 52 yaşında, metastatik invaziv duktal tip meme karsinomu olan kadın hastadır. Hasta jinekoloji bölümüne postmenapozal kanama şikayeti ile başvurdu. Patolojik incelemede hiperplastik tipte endometrial polip ve fokal bir alanda stroma içinde epiteloid hücre infiltrasyonu izlendi. İmmunohistokimyasal incelemede bu hücrelerin CD10 negatif, Pansitokeratin ve GCDFP-15 ile pozitif olduğu görüldü. Patolojik tanı fokal karsinom infiltrasyonu (meme kanseri ile uyumlu) içeren hiperplastik polip olarak raporlandı. Meme karsinomu tanısı ile takip edilen hastalara ait küretaj materyalleri patoloji rutininde sıkça yer almaktadır. Metastatik hastalık olasılığı akılda tutulmalı, materyalin tamamı incelemeye alınmalı ve patolojik inceleme; metastatik hastalığı ekarte etmek üzere dikkatle yapılmalıdır. Anahtar sözcükler: Karsinoma, duktal, meme, tümör metastazı, endometriyal tümörler Geliş tarihi

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“…Metastasisofextragenitalneoplasmstothegenitaltractisuncommon and mainly affects the ovaries and the vagina, but rarelytheuterusasinourcase [3,6,8,13].Breastcanceris the most common extragenital cancer to metastasize to the uterus,witharateof47% [2,8,14].Invasivelobularcarcinomaofthebreastisresponsibleformorethan80%ofmetas-tasesingynecologicorgans,muchmorethaninvasiveductal carcinoma.Inourcasealso,thepatienthadinvasivelobular carcinoma [3,6,15,16].…”

Section: Discussionmentioning

confidence: 99%

“…Metastasis from extragenital sites to the uterus is found in only 10% of patients, and the uterine corpus is mostly affected [1][2][3].Breastandgastrointestinaltumorsarethemost common extragenital tumors metastasizing to the uterus [1,4,5].Uterinemetastasisofbreastcancerhasbeenpreviously reported [6][7][8]tooccurin2-15%ofpatients,andlobularcarcinomaisthemostcommonhistopathologictypetometastasizetotheuterus [9].…”

Section: Introductionmentioning

confidence: 99%

Metastasis of Lobular Breast Carcinoma to the Uterus in a Patient under Anastrozole Therapy

Ustaalioglu¹,

Bılıcı²,

Şeker³

et al. 2009

Onkologie

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Background: Metastasis of extragenital neoplasms to the uterus are rarely encountered, and usually occur as a manifestation of advanced disease. Lobular carcinoma is the most common type of breast cancer that metastasizes to the uterus. Case Report: We report on a 56-yearold woman who 3 years previously was diagnosed with invasive lobular carcinoma of the breast and was treated with surgery followed by chemotherapy and radiotherapy. While the patient was on adjuvant anastrozole therapy for 2 years, she complained of vaginal bleeding. Because of endometrial thickening and a uterine leiomyoma detected during abdominal ultrasonographic ex-amination, a total hysterectomy with bilateral salpingooophorectomy was performed. Histopathologic examination of the specimens revealed carcinoma infiltration of the myometrium, endometrium, cervix, uterine tube, and left ovary. Immunohistochemical staining of tumoral cells with pancytokeratin and gross cystic disease fluid protein (GCDFP-15) proved the diagnosis of metastatic lobular breast carcinoma to the uterus. Conclusion: To our knowledge, this is the second case of lobular breast carcinoma metastasized to the uterus under anastrozole therapy. In women with lobular breast cancer under adjuvant anastrozole therapy, who present with vaginal bleeding, uterine metastasis of lobular carcinoma should be considered in the differential diagnosis.

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Abnormal uterine bleeding as a presentation of metastatic breast disease in a patient with advanced breast cancer

Abstract: Unusual uterine bleeding in a patient with breast cancer should alert the gynecologist to the possibility of metastatic breast disease. Furthermore, the metastasis to the uterus and to other organs of the genital tract can be considered as a preterminal event.

Cited by 23 publications

References 9 publications

Breast Cancer Masquerades as an Endometrial Cancer

Breast Cancer Masquerades as an Endometrial Cancer

Breast carcinoma metastasis to endometrial polyp (Case report and literature review)

Metastasis of Lobular Breast Carcinoma to the Uterus in a Patient under Anastrozole Therapy

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