Abnormal subcortical nuclei shapes in patients with type 2 diabetes mellitus

Ji, Chen; Zhang, Junxiang; Liu, Xuebing; Wang, Xiaoyang; Xu, Xingyan; Li, Hui; Cao, Bo; Yang, Yu-Hsuen; Lu, Jingjing; Chen, Ziqian

doi:10.1007/s00330-017-4790-3

Cited by 27 publications

(16 citation statements)

References 39 publications

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“…Accordingly, processing speed reflects ability in the interaction of cognitive processes which are essential for higher order cognitive and mental function. Actually, localized atrophy of the thalamus was related to slower cognitive processing speeds in patients with multiple sclerosis (Bergsland et al., 2016; Bisecco et al., 2018) and Type 2 diabetes mellitus (Chen et al., 2017). Thus, the interaction of the thalamus and other regions play an important role in processing speed.…”

Section: Discussionmentioning

confidence: 99%

Disrupted functional and structural connectivity within default mode network contribute to WMH-related cognitive impairment

Chen

Huang

et al. 2019

NeuroImage: Clinical

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Section: Discussionmentioning

confidence: 99%

Disrupted functional and structural connectivity within default mode network contribute to WMH-related cognitive impairment

Chen

Huang

et al. 2019

NeuroImage: Clinical

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“…These mechanisms have mainly been investigated in hippocampal neurons [ 18 , 19 , 20 , 21 , 22 , 23 ]. In addition, recent advances in neuroimaging, such as diffusion tensor imaging, have revealed that structural changes include not only areas associated with cognitive function, but also the motor and sensory cortices, basal ganglia, cerebellum, brainstem, and spinal cord, which are essential in generating and transmitting motor commands [ 24 , 25 , 26 , 27 ]. Furthermore, more direct data reveal changes in motor representations in the motor cortex and impaired conduction of the corticospinal tract (CST) in rodents with type 1 diabetes induced by streptozotocin (STZ) administration [ 28 , 29 ].…”

Section: Introductionmentioning

confidence: 99%

Diabetes Mellitus-Related Dysfunction of the Motor System

Muramatsu

2020

IJMS

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Although motor deficits in humans with diabetic neuropathy have been extensively researched, its effect on the motor system is thought to be lesser than that on the sensory system. Therefore, motor deficits are considered to be only due to sensory and muscle impairment. However, recent clinical and experimental studies have revealed that the brain and spinal cord, which are involved in the motor control of voluntary movement, are also affected by diabetes. This review focuses on the most important systems for voluntary motor control, mainly the cortico-muscular pathways, such as corticospinal tract and spinal motor neuron abnormalities. Specifically, axonal damage characterized by the proximodistal phenotype occurs in the corticospinal tract and motor neurons with long axons, and the transmission of motor commands from the brain to the muscles is impaired. These findings provide a new perspective to explain motor deficits in humans with diabetes. Finally, pharmacological and non-pharmacological treatment strategies for these disorders are presented.

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“…Moreover, the caudate is involved in spatial working memory (49). Previous neuroimaging studies demonstrated that patients with T2DM exhibited lower gray matter volume in the caudate nucleus (50–52). Prior studies showed that dysfunction of the caudate might lead to movement disorders, such as Parkinson’s disease and Huntington’s disease (53,54).…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Altered resting cerebral blood flow specific to patients with diabetic retinopathy revealed by arterial spin labeling perfusion magnetic resonance imaging

et al. 2020

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Background Previous neuroimaging studies have shown that patients with diabetic retinopathy (DR) were accompanied by abnormalities in cerebral functional and structural architecture, whereas the resting cerebral blood flow (CBF) alterations in patients with DR are not well understood. Purpose To explore CBF alterations in patients with DR using pseudo-continuous arterial spin labeling (pCASL) imaging. Material and Methods Thirty-one individuals with DR (15 men, 16 women; mean age = 53.38 ± 9.12 years) and 33 healthy controls (HC) (12 men, 21 women; mean age = 51.61 ± 9.84 years) closely matched for age, sex, and education, underwent pCASL imaging scans. Two-sample T test was conducted to compare different CBF values between two groups. Results Patients with DR exhibited significantly increased CBF values in the left middle temporal gyrus (Brodmann’s area, BA 22) and the bilateral supplementary motor area (BA3) and decreased CBF values in the bilateral calcarine (BA17,18) and bilateral caudate relative to HC group (two-tailed, voxel level at P < 0.01, Gaussian random field (GRF), cluster level at P < 0.05). Moreover, the HbA1c (%) level showed a positive correlation with CBF values in the bilateral caudate (r = 0.473, P = 0.007) in patients with DR. Conclusion Our results highlighted that patients with DR had abnormal CBF values in the visual cortices, caudate, middle temporal gyrus, and supplementary motor area, which might reflect vision and sensorimotor and cognition dysfunction in patients with DR. These findings might help us to understanding the neural mechanism of patients with DR.

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Abnormal subcortical nuclei shapes in patients with type 2 diabetes mellitus

Cited by 27 publications

References 39 publications

Disrupted functional and structural connectivity within default mode network contribute to WMH-related cognitive impairment

Disrupted functional and structural connectivity within default mode network contribute to WMH-related cognitive impairment

Diabetes Mellitus-Related Dysfunction of the Motor System

Altered resting cerebral blood flow specific to patients with diabetic retinopathy revealed by arterial spin labeling perfusion magnetic resonance imaging

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