Abnormal spontaneous brain activity in type 2 diabetic retinopathy revealed by amplitude of low-frequency fluctuations: a resting-state fMRI study

Wang, Z.-L.; Zou, Lin; Lu, Ziwei; Xie, Xinhui; Jia, Zhongzhi; Pan, Chunyan; Zhang, G.-X.; Ge, Xiaomin

doi:10.1016/j.crad.2016.11.012

Cited by 59 publications

(59 citation statements)

References 27 publications

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“…Based on independent component analysis, previous studies have shown that the posterior parietal cortex (angular gyrus and supramarginal gyrus), precuneus, and posterior cingulate are the main regions of the VSN (Beckmann et al, 2005;Smitha et al, 2017). Many studies reported that the VSN has abnormal neural intensity, reduced gray matter volume, and/or decreased perfusion of the precuneus and posterior cingulate (Cui et al, 2014;Peng et al, 2016;Liu et al, 2017;Wang et al, 2017;Wu et al, 2017), which is associated with impaired visuospatial function in T2DM (Cui et al, 2017). Here, our results suggest that the left cerebellar lobule VI is related to the impairment of visuospatial function in patients with T2DM.…”

Section: Decreased Connectivity Of the Cerebellum-cerebral Vsn In T2dmmentioning

confidence: 99%

“…Studies have found, for example, that disruption of the default-mode network (DMN) may be related to episodic memory impairment (Qi et al, 2017) and depression (Cui et al, 2015), whereas disruption of the executive control network (ECN) may lead to reduced working memory (Alvarenga et al, 2010) in patients with T2DM. In addition, T2DM studies have demonstrated abnormal neuronal activity in the core regions (posterior parietal and occipital cortex) of the visuospatial network (VSN) (Cui et al, 2014;Peng et al, 2016;Wang et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

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Altered Cerebellar-Cerebral Circuits in Patients With Type 2 Diabetes Mellitus

Zhang

Gao

et al. 2020

Front. Neurosci.

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The role of the cerebellum in type 2 diabetes mellitus (T2DM) has been receiving increased attention. However, the functional connectivity (FC) between the cerebellar subregions and the cerebral cortex has not been investigated in T2DM. Therefore, the purpose of this study was to investigate cerebellar-cerebral FC and the relationship between FC and clinical/cognitive variables in patients with T2DM. A total of 34 patients with T2DM and 30 healthy controls were recruited for this study to receive a neuropsychological assessment and undergo resting-state FC. We selected four subregions of the cerebellum (bilateral lobules IX, right and left Crus I/II, and left lobule VI) as regions of interest (ROIs) to examine the differences in cerebellar-cerebral circuits in patients with T2DM compared to healthy controls. Correlation analysis was performed to examine the relationship between FC and clinical/cognitive variables in the patients. Compared to healthy controls, patients with T2DM showed significantly decreased cerebellar-cerebral FC in the default-mode network (DMN), executive control network (ECN), and visuospatial network (VSN). In the T2DM group, the FC between the left cerebellar lobule VI and the right precuneus was negatively correlated with the Trail Making Test A (TMT-A) score (r = −0.430, P = 0.013), after a Bonferroni correction. In conclusion, patients with T2DM have altered FC between the cerebellar subregions and the cerebral networks involved in cognitive and emotional processing. This suggests that a range of cerebellar-cerebral circuits may be involved in the neuropathology of T2DM cognitive dysfunction.

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Section: Decreased Connectivity Of the Cerebellum-cerebral Vsn In T2dmmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Altered Cerebellar-Cerebral Circuits in Patients With Type 2 Diabetes Mellitus

Zhang

Gao

et al. 2020

Front. Neurosci.

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“…Previous neuroimaging studies demonstrated that specific functional and structural architecture changes in the brain are related to cognitive impairment in DR patients. Wang et al demonstrated that increased amplitude of low-frequency fluctuation (ALFF) values in the right occipital lobe was correlated with cognitive impairments in DR patients [12]. van Duinkerken et al reported that type 1 diabetes patients with proliferative retinopathy showed lower eigenvector centrality mapping and degree centrality in the bilateral thalamus and dorsal striatum, as well as increased eigenvector centrality mapping in the occipital cortex [13].…”

Section: Introductionmentioning

confidence: 99%

Large-Scale Neuronal Network Dysfunction in Diabetic Retinopathy

Huang

Tong

et al. 2020

Neural Plasticity

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Diabetic retinopathy (DR) patients are at an increased risk of cognitive decline and dementia. There is accumulating evidence that specific functional and structural architecture changes in the brain are related to cognitive impairment in DR patients. However, little is known regarding whether the functional architecture of resting-state networks (RSNs) changes in DR patients. The purpose of this study was to investigate the intranetwork functional connectivity (FC) and functional network connectivity (FNC) of RSN changes in DR patients using independent component analysis (ICA). Thirty-four DR patients (18 men and 16 women; mean age, 53.53±8.67 years) and 38 nondiabetic healthy controls (HCs) (15 men and 23 women; mean age, 48.63±11.83 years), closely matched for age, sex, and education, underwent resting-state magnetic resonance imaging scans. ICA was applied to extract the nine RSNs. Then, two-sample t-tests were conducted to investigate different intranetwork FCs within nine RSNs between the two groups. The FNC toolbox was used to assess interactions among RSNs. Pearson correlation analysis was conducted to explore the relationship between intranetwork FCs and clinical variables in the DR group. A receiver operating characteristic (ROC) curve was conducted to assess the ability of the intranetwork FCs of RSNs in discriminating between the two groups. Compared to the HC group, DR patients showed significant decreased intranetwork FCs within the basal ganglia network (BGN), visual network (VN), ventral default mode network (vDMN), right executive control network (rECN), salience network (SN), left executive control network (lECN), auditory network (AN), and dorsal default mode network (dDMN). In addition, FNC analysis showed increased VN-BGN, VN-vDMN, VN-dDMN, vDMN-lECN, SN-BGN, lECN-dDMN, and AN-BGN FNCs in the DR group, relative to the HC group. Furthermore, altered intranetwork FCs of RSNs were significantly correlated with the glycosylated hemoglobin (HbA1c) level in DR patients. A ROC curve showed that these specific intranetwork FCs of RSNs discriminated between the two groups with a high degree of sensitivity and specificity. Our study highlighted that DR patients had widespread deficits in both low-level perceptual and higher-order cognitive networks. Our results offer important insights into the neural mechanisms of visual loss and cognitive decline in DR patients.

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“…ALFF has been used to study neurological conditions, such as optic neuritis [ 19 ], Parkinson’s disease [ 20 ], epilepsy [ 21 ], bipolar disorder [ 22 ], and schizophrenia [ 23 ]. ALFF also has been used widely in research on ocular diseases, such as MB [ 24 ], high myopia [ 25 ], glaucoma [ 26 ], optic neuritis [ 27 ], and diabetic retinopathy [ 28 ].…”

Section: Introductionmentioning

confidence: 99%