Large-Scale Neuronal Network Dysfunction in Diabetic Retinopathy

Huang, Xin; Tong, Yan; Qi, Chen-Xing; Dan, Handong; Deng, Qinqin; Shen, Yin

doi:10.1155/2020/6872508

Cited by 16 publications

(16 citation statements)

References 84 publications

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“…Among the 29 components arising from ICA, 10 components (7 meaningful RSNs) were selected as the focus of subsequent analysis through visual inspection based on previous rs-fMRI studies ( Bernas et al, 2018 ; Huang et al, 2020 ; Li et al, 2020 ; Xing et al, 2020 ). A one-sample t -test, which was corrected by a critical threshold with p < 0.01 (family-wise error correction, FWE), was performed on each RSN to determine the z-maps for each group.…”

Section: Methodsmentioning

confidence: 99%

Disrupted intra- and inter-network connectivity in unilateral acute tinnitus with hearing loss

Zhou

Chen

et al. 2022

Front. Aging Neurosci.

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PurposeCurrently, the underlying neurophysiological mechanism of acute tinnitus is still poorly understood. This study aimed to explore differences in brain functional connectivity (FC) within and between resting-state networks (RSNs) in acute tinnitus patients with hearing loss (ATHL). Furthermore, it also evaluated the correlations between FC alterations and clinical characteristics.MethodsTwo matched groups of 40 patients and 40 healthy controls (HCs) were included. Independent component analysis (ICA) was employed to obtain RSNs and FC differences were calculated within RSNs. In addition, the relationships between networks were conducted using functional network connectivity (FNC) analysis. Finally, an analysis of correlation was used to evaluate the relationship between FNC abnormalities and clinical data.ResultsResults of this study found that seven major RSNs including the auditory network (AN), cerebellum network (CN), default mode network (DMN), executive control network (ECN), sensorimotor network (SMN), ventral attention network (VAN), and visual network (VN) were extracted using the group ICA in both groups. Furthermore, it was noted that the ATHL group showed aberrant FC within the CN, ECN, and VN as compared with HCs. Moreover, different patterns of network interactions were observed between groups, including the SMN-ECN, SMN-CN, ECN-AN, DMN-VAN, and DMN-CN connections. The correlations between functional disconnection and clinical characteristics in ATHL were also found in this study.ConclusionIn conclusion, this study indicated widespread alterations of intra- and inter-network connectivity in ATHL, suggesting that multiple large-scale network dysfunctions and interactions are involved in the early stage. Furthermore, our findings may provide new perspectives to understand the neuropathophysiological mechanism of acute tinnitus.

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Section: Methodsmentioning

confidence: 99%

Disrupted intra- and inter-network connectivity in unilateral acute tinnitus with hearing loss

Zhou

Chen

et al. 2022

Front. Aging Neurosci.

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“…Another study revealed that DR patients had reduced gray matter density in the right occipital lobe ( 32 ). Our previous study demonstrated that DR patients had decreased functional connectivity in the visual network ( 33 ). Consistent with these findings, the present study revealed that patients with DR had significantly lower dALFF values in the middle occipital gyrus.…”

Section: Discussionmentioning

confidence: 99%

Dynamic Changes of Amplitude of Low-Frequency Fluctuations in Patients With Diabetic Retinopathy

Huang

Wen

et al. 2021

Front. Neurol.

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Background: Growing evidence demonstrate that diabetic retinopathy (DR) patients have a high risk of cognitive decline and exhibit abnormal brain activity. However, neuroimaging studies thus far have focused on static cerebral activity changes in DR patients. The characteristics of dynamic cerebral activity in patients with DR are poorly understood.Purpose: The purpose of the study was to investigate the dynamic cerebral activity changes in patients with DR using the dynamic amplitude of low-frequency fluctuation (dALFF) method.Materials and methods: Thirty-four DR patients (18 men and 16 women) and 38 healthy controls (HCs) (18 males and 20 females) closely matched in age, sex, and education were enrolled in this study. The dALFF method was used to investigate dynamic intrinsic brain activity differences between the DR and HC groups.Results: Compared with HCs, DR patients exhibited increased dALFF variability in the right brainstem, left cerebellum_8, left cerebellum_9, and left parahippocampal gyrus. In contrast, DR patients exhibited decreased dALFF variability in the left middle occipital gyrus and right middle occipital gyrus.Conclusion: Our study highlighted that DR patients showed abnormal variability of dALFF in the visual cortices, cerebellum, and parahippocampal gyrus. These findings suggest impaired visual and motor and memory function in DR individuals. Thus, abnormal dynamic spontaneous brain activity might be involved in the pathophysiology of DR.

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“… 28 Additionally, a recent analysis revealed that patients with DR had abnormal intranetwork FCs in the bilateral thalamus and right caudate nucleus of the basal ganglia network, suggesting that DR patients may exhibit movement control dysfunction. 29 Dai et al found that characteristic path length was enhanced and degree distribution was reduced (indicating greater connectivity) in the caudate nucleus and most frontal gyri of patients with DR, which may relate to compensatory recruitment. 11 Consistent with the prior ﬁndings, our results showed that the DR group had enhanced FC between the bilateral V1 and bilateral caudate nucleus, which may reflect enhanced visuomotor function in patients with DR. We presume that the reorganization of the V1 and motor areas might contribute to the enhanced compensatory connectivity between the caudate and V1.…”

Section: Discussionmentioning

confidence: 99%

Altered Functional Connectivity Strength of Primary Visual Cortex in Subjects with Diabetic Retinopathy

Qi¹,

Huang²,

Tong³

et al. 2021

DMSO

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The purpose of the study was to find the differences in intrinsic functional connectivity (FC) patterns of the primary visual area (V1) among diabetic retinopathy (DR), diabetes mellitus (DM), and healthy controls (HCs) applying resting-state functional magnetic resonance imaging (rs-fMRI). Patients and Methods: Thirty-five subjects with DR (18 males and 17 females), 22 DM (10 males and 12 females) and 38 HCs (16 males and 22 females) matched for sex, age, and education underwent rs-fMRI scanning. Seed-based FC analysis was performed to find the alterations in the intrinsic FC patterns of V1 in DR compared with DM and HCs. Results: The study found that DR patients had a significant lower FC between the bilateral calcarine (CAL)/left lingual gyrus (LING) (BA 17/18) and the left V1, and between the bilateral CAL/left LING (BA 17/18) and the right V1 compared with the HCs. Meanwhile, patients with DR exhibited higher FC strength between the left V1 and the bilateral Caudate/ Olfactory/Orbital superior frontal gyrus (OSFG), and between the bilateral Caudate/ Olfactory/OSFG (BA 3/4/6) and the right V1. Compared with DM group, patients with DR showed increased FC strength between the right CAL (BA 17/18) and the right V1. DM group exhibited lower FC strength between the left fusiform and the left V1, and between the bilateral CAL and the right V1 when compared with HCs. Moreover, DM group was observed to have higher FC strength between the left superior frontal gyrus and the left V1. Conclusion: Our findings indicated that DR patients exhibited FC disruptions between V1 and higher visual regions at rest, which may reflect the aberrant information communication in the V1 area of DR individuals. The findings offer important insights into the neuromechanism of vision disorder in DR patients.

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Large-Scale Neuronal Network Dysfunction in Diabetic Retinopathy

Cited by 16 publications

References 84 publications

Disrupted intra- and inter-network connectivity in unilateral acute tinnitus with hearing loss

Disrupted intra- and inter-network connectivity in unilateral acute tinnitus with hearing loss

Dynamic Changes of Amplitude of Low-Frequency Fluctuations in Patients With Diabetic Retinopathy

Altered Functional Connectivity Strength of Primary Visual Cortex in Subjects with Diabetic Retinopathy

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