Abnormal sexuality in Parkinson's disease: fact or fancy?

Ferrucci, Roberta; Panzeri, Marta; Ronconi, Lucia; Ardolino, Gianluca; Cogiamanian, F.; Barbieri, S.; Barone, Paolo; Bertolasi, Laura; Padovani, Alessandro; Priori, Alberto

doi:10.1016/j.jns.2016.07.058

Cited by 22 publications

(27 citation statements)

References 36 publications

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“…Contradictory findings about SD in PD males and its underlying factors were reported by few previous studies [5]. In this study, we investigated the SD among male PD patients compared to healthy controls, the effect of all proposed factors (including age, motor severity, and depression), its relation to different non-motor symptoms, and its impact on HRQoL.…”

Section: Introductionmentioning

confidence: 88%

“…In PD, sexual dysfunction is one of the disabling and less investigated NMSs [4]. Contradictory findings were reported by different studies, including significantly worse or similar sexual functions, compared to controls [5,6]. Using the NMSS, 41.7 and 34.5% of Egyptian PD patients reported problems in having sex and altered interest in sex, respectively.…”

Section: Introductionmentioning

confidence: 94%

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Sexual dysfunction in male patients with Parkinson’s disease: related factors and impact on quality of life

et al. 2020

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Background Sexual dysfunction (SD) is a common, yet under-reported, non-motor symptom (NMS) of Parkinson's disease (PD). The present study investigated the sexual functions in PD male patients, its correlation with motor and other NMSs, and their impact on health-related quality of life (HRQoL). Methods The sexual functions of 40 PD male patients were assessed using the International Index of Erectile Function (IIEF) and compared to 25 healthy age-matched controls. Patients were evaluated using the NMS Scale (NMSS) and the Arabic version of the Parkinson's-Disease Questionnaire (PDQ-39). We compared the sexual functions of younger (≤ 55 years) and elder (> 55 years) males and tested the correlations between sexual functions and motor, other NMSs, and HRQoL. Results Seventy percent of PD male patients reported erectile dysfunction. They showed significantly worse total (p < 0.001) and subscores of IIEF, compared to healthy controls. The total IIEF was inversely correlated to age of patients (p = 0.013), age at onset (p = 0.043), total, cognitive/mood, gastrointestinal and urinary domains of NMSS, and the cognitive domain of PDQ-39 (p = 0.013). Age was the main predictor (ß = − 0.581, p = 0.006) of SD. Elder patients showed worse sexual functions, stronger correlations to other NMSs, and more impact on HRQoL than younger patients. Conclusion Sexual functions are worse among PD male patients with age as the main predictor. SD was associated with worse cognitive/mood and urinary domains of NMSS and has a negative impact on the patients' HRQoL among elder males.

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Section: Introductionmentioning

confidence: 88%

Section: Introductionmentioning

confidence: 94%

Sexual dysfunction in male patients with Parkinson’s disease: related factors and impact on quality of life

et al. 2020

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“…125 Sexual dysfunction is more likely to become evident in PD patients with depression 123 and with the postural instability-gait disorder phenotype. 126 In contrast to the studies detailed above, a recent study in which 121 PD patients were compared with 123 non-PD controls did not find any differences between the two groups in four different sexual function scales, 127 illustrating the fact that additional research into sexual dysfunction in PD is sorely needed.…”

Section: Sexual Dysfunctionmentioning

confidence: 72%

Management of Autonomic Dysfunction in Parkinson's Disease

Pfeiffer

2017

Semin Neurol

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Autonomic dysfunction is a frequent and important nonmotor feature of Parkinson's disease (PD). Autonomic dysfunction in PD spans a broad clinical spectrum. Cardiovascular dysfunction is characterized most prominently by orthostatic hypotension. Gastrointestinal dysfunction can involve virtually all levels of the gastrointestinal tract. Urinary dysfunction can entail either too frequent voiding or difficulty voiding. Sexual dysfunction is frequent and frustrating for both the patient and the partner. Alterations in sweating and body temperature are not widely recognized, but often are present. The presence of effective treatment for at least some aspects of autonomic dysfunction makes it vitally important that the assessment of autonomic dysfunction be a regular component of the neurologic history and examination for individuals with PD.

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“…It can be a decrease in desire, a difficulty in reaching orgasm and, for men, disorders of erection or ejaculation. 16 These sexual problems can be related to age (as for PD, the risk of developing erectile dysfunction increases after age 50) or to the disease itself. Indeed, dopamine plays a major role in libido and the occurrence of erection.…”

Section: Discussionmentioning

confidence: 99%

“…The focus of management is the relief of the clinically dominant motor symptoms of PD, but the non-motor features of PD also need attention. 12 In particular, sexual disorders (SD), those are commonly reported in patients with PD 15,16 and have attracted attention since the important publication of Giovannoni et al 17 The incidence of SD related to the increasing use of DA medication 18 has been explained by the main role of DA in sexual function. DA is a key neurotransmitter in the control of sexual functions, potentially involved in both sexual motivation and control of sexual performance.…”

Section: Introductionmentioning

confidence: 99%

Male Sexual Disorders in Patients with Parkinson Disease: Treatment with Natural Remedies

Mireille¹

2017

ATROA

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In patients with PD, sexual disorders usually begin after the onset AbstractParkinson's disease (PD) is a neurodegenerative disorder caused by a progressive deterioration of midbrain dopamine neurons in the substantia nigra. The incidence of PD in male is higher than that in women, but psychological symptoms are as varied as the motor symptoms in both gender. Psychological symptoms encompass a decrease in sexual desire with a long list of thymic, cognitive, behavioral, and neuropsychiatric complications. Their origin can be attributed to the natural course of the disease, side effects of treatment, or both. Clinical researches are mainly focused on the dominant motor symptoms of PD, but the nonmotor features of PD also need attention. Sexual dysfunctions (SD) are one of the most neglected nonmotor symptoms in PD. SD usually begin after the onset of motor disorders and many patients receiving DA agonists as treatment manifest uncontrollable sexual desire, playing thus a major role in the deterioration of the life's quality of patients and their partners. Research articles were retrieved from PubMed and Google using relevant keywords. Overall, this review emphasize on the sexual disorders widely reported in patients with PD and the types of natural products that are potential future supplementary agents in their control.

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Abnormal sexuality in Parkinson's disease: fact or fancy?

Cited by 22 publications

References 36 publications

Sexual dysfunction in male patients with Parkinson’s disease: related factors and impact on quality of life

Sexual dysfunction in male patients with Parkinson’s disease: related factors and impact on quality of life

Management of Autonomic Dysfunction in Parkinson's Disease

Male Sexual Disorders in Patients with Parkinson Disease: Treatment with Natural Remedies

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