Abnormal serum iron markers in chronic hepatitis B virus infection may be because of liver injury

Mao, Weilin; Hu, Ying; Lou, Yiting; Chen, YueMei; Zhang, Juanwen

doi:10.1097/meg.0000000000000247

Cited by 28 publications

(29 citation statements)

References 23 publications

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“…To support this finding, a strong association between serum ferritin and HCC in patients with chronic liver disease was observed . In addition, serum iron and ferritin levels were found to be higher in HBV‐infected patients with cirrhosis compared with HBV‐infected patients without cirrhosis, suggesting that ferritin may play an important role in angiogenesis …”

Section: Role Of Iron In Oncogenesis By Virusesmentioning

confidence: 87%

Role of iron in cancer development by viruses

Shoja

Chenari

Jafarpour

et al. 2019

Reviews in Medical Virology

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Increased levels of iron in body are attributed to higher cancer risk. Given the fact that 16% of all human cancers are caused by viral infections, iron is suggested to play an important role in carcinogenesis particularly those induced by viral infections. The present study provides an updated summary of the literature and the plausible mechanisms of iron involvement in cancer development by viruses. Our understanding about the interplay between viral infections and iron in different settings particularly cancer development is yet to be improved as it may shed a new light in development of new therapeutic strategies.

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Section: Role Of Iron In Oncogenesis By Virusesmentioning

confidence: 87%

Role of iron in cancer development by viruses

Shoja

Chenari

Jafarpour

et al. 2019

Reviews in Medical Virology

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“…Hepatitis B virus-infected patients with cirrhosis had low serum iron binding capacity and high ferritin in comparison with non-cirrhotic hepatitis B virus and hepatitis C infected patients. 18 Prieto J et al observed that higher ferritin was common in all patients with chronic liver disease. But most of the studies contradicted it.…”

Section: Discussionmentioning

confidence: 99%

Serum Iron Parameters in Alcoholic Cirrhosis, Cryptogenic Cirrhosis, Chronic Hepatitis B and Chronic Hepatitis C

C¹,

Lonappan²,

George³

et al. 2016

jebmh

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BACKGROUND Regular monitoring of serum iron parameters is helpful for assessing the severity of alcoholic liver disease. Assessment of serum iron parameters are used for screening hereditary haemochromatosis in chronic liver disease. Serum iron parameters in chronic liver disease have not been clearly described in most of the studies. The aim of this study was to assess the serum iron, Total Iron Binding Capacity (TIBC), transferrin saturation and ferritin levels in common chronic liver disease like alcoholic cirrhosis, cryptogenic cirrhosis, chronic hepatitis C and chronic hepatitis B. MATERIALS AND METHODS 110 consecutive patients with chronic liver disease admitted to the Gastroenterology Department, Government Medical College, Kozhikode were selected for the study. The categories of chronic liver disease included in our study were alcoholic cirrhosis (Group I, n = 40), cryptogenic cirrhosis (Group II, n = 30), chronic hepatitis C (Group III, n = 20) and chronic hepatitis B (Group IV, n = 20). Serum iron, ferritin, total iron binding capacity and transferrin saturation were estimated in the fasting sample. Statistical Analysis-Analysis was performed using nonparametric Kruskal-Wallis and Bonferroni test to assess statistical significance of difference of continuous variables among and between groups, respectively. The results were considered statistically significant at the level of p <0.05. RESULTS The serum iron level was normal and total iron binding capacity was low in all the four groups of chronic liver disease. Serum ferritin and transferrin saturation were significantly higher in alcoholic cirrhosis in comparison with cryptogenic cirrhosis and chronic hepatitis B, but was not statistically significant in comparison with chronic hepatitis C. CONCLUSION We observed irregularities in iron status in patients with alcoholic cirrhosis, cryptogenic cirrhosis, chronic hepatitis C and chronic hepatitis B.

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“…It was shown that as hepatic parenchymal failure progresses, serum total iron binding capacity (i.e. TF activity) decreases (166,(171)(172)(173)(174)(175) and consequently TS increases. Increased TS was found to be a good predictor of the status of hepatic iron deposits (and fibrosis) in CHC (34,71,176,177).…”

Section: Hypotransferrinemia As a Cause Of Hepatic Siderosis In Cldsmentioning

confidence: 99%

Chronic liver diseases and iron: a concise review with emphasis on hypotransferrinemia and hypohepcidinemia

Büyükaşık¹,

Büyükaşık

2016

Turk J Med Sci

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Iron studies in chronic liver diseases (CLDs) have a long history. Currently we can mention certainties, uncertainties, and hopes related to this topic. It is certain that iron metabolism problems and hepatic siderosis are frequent in CLDs and they get more frequent as CLD progresses, but true iron overload is rare. There are conflicting literature data on the mechanism of siderosis, the role of iron in CLD pathogenesis, and the potential benefits of iron removal. We may hope that pharmacological approaches targeting iron metabolism disorders of CLD will be actively evaluated in the future. In this review, we aimed to present a general outlook of this extensively studied topic.

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Abnormal serum iron markers in chronic hepatitis B virus infection may be because of liver injury

Cited by 28 publications

References 23 publications

Role of iron in cancer development by viruses

Role of iron in cancer development by viruses

Serum Iron Parameters in Alcoholic Cirrhosis, Cryptogenic Cirrhosis, Chronic Hepatitis B and Chronic Hepatitis C

Chronic liver diseases and iron: a concise review with emphasis on hypotransferrinemia and hypohepcidinemia

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