Abnormal regional homogeneity in patients with irritable bowel syndrome: A resting‐state functional <scp>MRI</scp> study

Ke, Jun; Qi, Rongfeng; Liu, C; Xu, Qiang; Wang, F; Zhang, L; Lu, Guang Ming

doi:10.1111/nmo.12692

Cited by 36 publications

(33 citation statements)

References 41 publications

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“…The IPL is also implicated in pain modulation (Schwedt and Chong, 2014). A previous study demonstrated lower spontaneous brain activity in bilateral inferior parietal cortices in IBS patients (Ke et al, 2015); therefore, our results are compatible with previous neuroimaging studies in IBS.…”

Section: Discussionsupporting

confidence: 93%

“…Few studies have reported abnormalities in these regions in IBS patients. Ke et al (2015) showed increased regional synchronization of cerebellum regions in IBS; however, the consistency of these findings needs to be confirmed in future studies.…”

Section: Discussionmentioning

confidence: 84%

“…Convergent evidence has suggested that the thalamus was more activated in IBS patients than the HCs during visceral distension (Ringel et al, 2003; Yuan et al, 2003) and cutaneous heat stimuli (Verne et al, 2003). In a recent rs-fMRI study using regional homogeneity (ReHo), an indicator measuring the degree of regional synchronization of fMRI time series (Zang et al, 2004), Ke et al (2015) reported higher regional synchronization in the thalamus of IBS patients relative to controls. The ReHo in that study and VMHC used in this study focus on the degree of regional- and interhemispheric-coordination, respectively.…”

Section: Discussionmentioning

confidence: 99%

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Disturbed Interhemispheric Functional Connectivity Rather than Structural Connectivity in Irritable Bowel Syndrome

Liu

Weng

et al. 2016

Front. Mol. Neurosci.

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Neuroimaging studies have demonstrated that irritable bowel syndrome (IBS)—a relapsing functional bowel disorder—presents with disrupted brain connections. However, little is known about the alterations of interhemispheric functional connectivity and underlying structural connectivity in IBS. This study combined resting-state functional magnetic resonance imaging (rs-fMRI) and diffusion tensor imaging (DTI) to investigate changes in interhemispheric coordination in IBS patients. Resting-state functional and structural magnetic resonance images were acquired from 65 IBS patients and 67 healthy controls (HCs; matched for age, sex and educational level). Interhemispheric voxel-mirrored homotopic connectivity (VMHC) was calculated and compared between groups. Homotopic regions showing abnormal VMHC in patients were targeted as regions of interest (ROIs) for analysis of DTI tractography. The fractional anisotropy (FA), fiber number and fiber length were compared between groups. Statistical analysis was also performed by including anxiety and depression as covariates to evaluate their effect. A Pearson correlation analysis between abnormal interhemispheric connectivity and clinical indices of IBS patients was performed. Compared to HCs, IBS patients had higher interhemispheric functional connectivity between bilateral thalami, cuneus, posterior cingulate cortices (PCC), lingual gyri and inferior occipital/cerebellum lobes, as well as lower interhemispheric functional connectivity between bilateral ventral anterior cingulate cortices (vACC) and inferior parietal lobules (IPL). The inclusion of anxiety and depression as covariates abolished VMHC difference in vACC. Microstructural features of white matter tracts connecting functionally abnormal regions did not reveal any differences between the groups. VMHC values in vACC negatively correlated with the quality of life (QOL) scores of patients. In conclusion, this study provides preliminary evidence of the disrupted functional coordination rather than anatomic coordination between interhemispheric regions within the cortex-thalamus circuit in IBS patients, which could partly account for the enhanced visceral information processing and impaired endogenous pain or emotion inhibition associated with IBS.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 84%

Section: Discussionmentioning

confidence: 99%

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Disturbed Interhemispheric Functional Connectivity Rather than Structural Connectivity in Irritable Bowel Syndrome

Liu

Weng

et al. 2016

Front. Mol. Neurosci.

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“…The latter concept has been challenged by growing evidence showing low-grade inflammatory changes in the gut and altered gut-brain axis signaling. 1,2 According to the Rome III classification, FBDs include the irritable bowel syndrome (IBS), functional bloating (FB), functional constipation, functional diarrhea, and unspecified FBD, and they are attributed to abnormalities likely originating from the small bowel, colon, and rectum. 3,4 Since FBDs lack objective biomarkers, their diagnosis is based on the clinical symptoms reported by patients, physical examination, and the exclusion of alarm symptoms/signs (eg, blood in stools, anemia, weight loss, and others).…”

Section: Introductionmentioning

confidence: 99%

Dietary Triggers in Irritable Bowel Syndrome: Is There a Role for Gluten?

Volta

Sánchez

Boschetti

et al. 2016

J Neurogastroenterol Motil

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A tight link exists between dietary factors and irritable bowel syndrome (IBS), one of the most common functional syndromes, characterized by abdominal pain/discomfort, bloating and alternating bowel habits. Amongst the variety of foods potentially evoking "food sensitivity", gluten and other wheat proteins including amylase trypsin inhibitors represent the culprits that recently have drawn the attention of the scientific community. Therefore, a newly emerging condition termed non-celiac gluten sensitivity (NCGS) or nonceliac wheat sensitivity (NCWS) is now well established in the clinical practice. Notably, patients with NCGS/NCWS have symptoms that mimic those present in IBS. The mechanisms by which gluten or other wheat proteins trigger symptoms are poorly understood and the lack of specific biomarkers hampers diagnosis of this condition. The present review aimed at providing an update to physicians and scientists regarding the following main topics: the experimental and clinical evidence on the role of gluten/wheat in IBS; how to diagnose patients with functional symptoms attributable to gluten/wheat sensitivity; the importance of double-blind placebo controlled cross-over trials as confirmatory assays of gluten/wheat sensitivity; and finally, dietary measures for gluten/wheat sensitive patients. The analysis of current evidence proposes that gluten/wheat sensitivity can indeed represent a subset of the broad spectrum of patients with a clinical presentation of IBS. (J Neurogastroenterol Motil 2016;22:547-557)

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“…61,68,81 ReHo is basically a voxel-based connectivity analysis that measures the regional similarity of the signals between the specific voxel and its neighboring voxels. 59,67,82 Of all the multivariate analyses applied in FGIDs studies, ICA pattern classification is the most familiar. 29,38,58 ICA works on the assumption that an fMRI signal is linearly composed of several (spatially or temporally) independent signals, and that the original fMRI signal is separated into independent groups.…”

Section: 77mentioning

confidence: 99%

How to Perform and Interpret Functional Magnetic Resonance Imaging Studies in Functional Gastrointestinal Disorders

Lee

Preißl

Enck

2017

J Neurogastroenterol Motil

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Functional neuroimaging studies have revealed the importance of the role of cognitive and psychological factors and the dysregulation of the brain-gut axis in functional gastrointestinal disorder patients. Although only a small number of neuroimaging studies have been conducted in functional gastrointestinal disorder patients, and despite the fact that the neuroimaging technique requires a high level of knowledge, the technique still has a great deal of potential. The application of functional magnetic resonance imaging (fMRI) technique in functional gastrointestinal disorders should provide novel methods of diagnosing and treating patients. In this review, basic knowledge and technical/practical issues of fMRI will be introduced to clinicians.

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Abnormal regional homogeneity in patients with irritable bowel syndrome: A resting‐state functional MRI study

Abstract: IBS patients have abnormal local synchronization of spontaneous brain activity in regions involved in visceral afferent processing, emotional arousal, and cognitive modulation. Combining rs-fMRI and ReHo analysis seems to be a valuable approach to investigate the neural basis of IBS.

Cited by 36 publications

References 41 publications

Disturbed Interhemispheric Functional Connectivity Rather than Structural Connectivity in Irritable Bowel Syndrome

Disturbed Interhemispheric Functional Connectivity Rather than Structural Connectivity in Irritable Bowel Syndrome

Dietary Triggers in Irritable Bowel Syndrome: Is There a Role for Gluten?

How to Perform and Interpret Functional Magnetic Resonance Imaging Studies in Functional Gastrointestinal Disorders

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