Abnormal reactions to environmental stress in elderly persons with anxiety disorders: Evidence from a population study of diurnal cortisol changes

Chaudieu, Isabelle; Beluche, Isabelle; Norton, Joanna; Boulenger, Jean‐Philippe; Ritchie, Karen; Ancelin, Marie-Laure

doi:10.1016/j.jad.2007.07.025

Cited by 75 publications

(69 citation statements)

References 38 publications

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“…Subsequently, high levels of cortisol induced the volume reduction of the Hip, which is closely related to the impairment of explicit memory abilities (Monk et al, 2002). In addition, a neurophysiological study (Chaudieu et al, 2008) suggested that GAD symptoms were closely related to an increment of cortisol concentration. Furthermore, a structure-function correlation study (Harms et al, 2013) demonstrated a positive correlation between the GM volume of the Hip and functional activity during working memory recognition tasks in patients with psychosis.…”

Section: Discussionmentioning

confidence: 99%

Explicit verbal memory impairments associated with brain functional deficits and morphological alterations in patients with generalized anxiety disorder

Moon

Yang

Jeong

2015

Journal of Affective Disorders

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Section: Discussionmentioning

confidence: 99%

Explicit verbal memory impairments associated with brain functional deficits and morphological alterations in patients with generalized anxiety disorder

Moon

Yang

Jeong

2015

Journal of Affective Disorders

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“…Additionally, it has long been speculated that chronic elevations of stress-related hormones such as cortisol can weaken multiple physiological systems of older adults resulting in impaired cardiovascular and immune function, as well as contributing to dementia, and mood and anxiety disorders. Recently it has been reported that unlike elderly subjects without psychiatric disorder, elderly subjects with anxiety disorders showed a greater increase in cortisol secretion following exposure to a stressor (Chaudieu et al, 2008). Furthermore, while children and adolescents display elevated cortisol levels to persistent anxiety, associations between cortisol levels and anxiety disorders have not been reported (Greaves-Lord et al, 2007;Kallen et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Salivary cortisol is associated with diagnosis and severity of late-life generalized anxiety disorder

Mantella

Butters

Amico

et al. 2008

Psychoneuroendocrinology

190

151

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SummaryAge-associated alterations in hypothalamic-pituitary-adrenal (HPA) axis functioning may make individuals more susceptible to HPA dysregulation in the context of mood and anxiety disorders. Little to no research has been done to examine HPA axis function in generalized anxiety disorder (GAD), particularly in late-life GAD, the most prevalent anxiety disorder in the elderly. The study sample consisted of 71 GAD subjects and 40 nonanxious comparison subjects over 60 years of age. We examined the hypotheses that elderly individuals with GAD will have elevated salivary cortisol levels compared to nonanxious subjects, and that elevated cortisol levels in GAD will be associated with measures of symptom severity. We report that late-life GAD is characterized by elevated basal salivary cortisol levels, with higher peak cortisol levels and larger areas under the curve, compared to nonanxious subjects. Additionally, severity of GAD as measured by the GAD Severity Scale and the Penn State Worry Questionnaire are positively correlated with cortisol levels. These data demonstrate HPA axis dysfunction in late-life GAD and suggest the need for additional research on the influence of aging on HPA axis function in mood and anxiety disorders.

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“…Although this rate is less than depression patients, it indicates that there is also an abnormal response to stress in GAD patients and there is a defect in regulatory feedback mechanisms of HPA axis. There are reports stating that cortisol levels in GAD patients are low (6,7), normal (8) and-in elderly patients-high (9,10). In conclusion, findings on HPA axis abnormalities in PD and GAD appear to be conflicting and inadequate (11).…”

Section: Introductionmentioning

confidence: 82%

Evaluation of hypothalamo-pituitary-adrenal axis activity by using dexamethasone suppression test in patients with panic disorder and generalized anxiety disorder

Hacımusalar¹,

Eşel²

2017

Dusunen Adam

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Evaluation of hypothalamo-pituitary-adrenal axis activity by using dexamethasone suppression test in patients with panic disorder and generalized anxiety disorderObjective: The aim of this study was to investigate the role of hypothalamo-pituitary-adrenal (HPA) axis activity on the pathophysiology of anxiety disorders by examining the HPA axis activity in patients with panic disorder (PD) and generalized anxiety disorder (GAD).Method: Baseline and post dexamethasone suppression test (DST) serum concentrations of cortisol and dehydroepiandrosterone-sulfate (DHEA-S) were measured in patients with PD (n=24), GAD (n=21) and in healthy controls (n=20). Results:The baseline cortisol levels in GAD group were found lower than those of the patients with PD and healthy controls. Cortisol suppression by dexamethasone in GAD group was found to be lower than PD patients and healthy controls. Baseline and post-DST DHEA-S levels in the patients with PD and GAD were similar to those of the healthy controls. Yöntem: PB (n=24) ve YAB (n=21) olan hastalarda ve sağlıklı kontrollerde (n=20) bazal ve deksametazon baskılama testi (DST) uygulaması sonrasında kortizol ve dehidroepiandrosteron-sülfat (DHEA-S) değerleri ölçüldü.Bulgular: YAB grubunun bazal kortizol düzeyleri kontrol ve PB grubuna göre düşük bulundu. Ayrıca YAB grubunda deksametazonun kortizolu baskılaması kontrol ve PB grubuna göre düşük bulundu. PB ve YAB hastalarında bazal ve DST sonu DHEA-S düzeyleri kontrol grubuna benzer bulundu.Sonuç: YAB hastalarında bazal kortizol düzeyinin düşük olması ve DST'de kortizol baskılanmasının yetersiz oluşu bu hastalarda hem kortikotropin salgılatıcı hormon reseptörlerinde, hem de glukokortikoid reseptörlerinde bir aşağı ayarlama (down-regulation) olduğunu akla getirmektedir.Anahtar kelimeler: Dehidroepiandrosteron, deksametazon, yaygın anksiyete bozukluğu, panik bozukluğu

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Abnormal reactions to environmental stress in elderly persons with anxiety disorders: Evidence from a population study of diurnal cortisol changes

Abstract: Background: Cortisol secretion in elderly persons with anxiety disorders exposed to common

Cited by 75 publications

References 38 publications

Explicit verbal memory impairments associated with brain functional deficits and morphological alterations in patients with generalized anxiety disorder

Explicit verbal memory impairments associated with brain functional deficits and morphological alterations in patients with generalized anxiety disorder

Salivary cortisol is associated with diagnosis and severity of late-life generalized anxiety disorder

Evaluation of hypothalamo-pituitary-adrenal axis activity by using dexamethasone suppression test in patients with panic disorder and generalized anxiety disorder

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