Abnormal microstructural development of the cerebral cortex in neonates with congenital heart disease is associated with impaired cerebral oxygen delivery

Kelly, Christopher; Christiaens, Daan; Batallé, Dafnis; Makropoulos, Antonios; Cordero‐Grande, Lucilio; Steinweg, Johannes K.; O’Muircheartaigh, Jonathan; Khan, Hammad; Lee, Geraint; Victor, Suresh; Alexander, Daniel C.; Zhang, Hui; Simpson, John; Hajnal, Joseph V.; Edwards, A. David; Rutherford, Mary; Counsell, Serena

doi:10.1101/332247

Cited by 6 publications

(8 citation statements)

References 62 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…CHD (without Down syndrome) are generally associated with impaired clinical neurodevelopment and an underlying reduction in cortical grey matter volumes, gyrification index (indicative of less complex cortical folding), and abnormal cortical microstructure in the neonatal period. These changes were further associated with reduced cerebral oxygen delivery . This therefore highlights the importance of understanding the additional and as yet unexplored, effects of a CHD on brain development in Down syndrome.…”

Section: What We Do Not Knowmentioning

confidence: 86%

“…These changes were further associated with reduced cerebral oxygen delivery. 77,78 This therefore highlights the importance of understanding the additional and as yet unexplored, effects of a CHD on brain development in Down syndrome. Mouse models are also useful for this as the Ts65Dn, 79 Ts1Cje, 80 Tc1, 81 Dp1Tyb, 70 and the genetically similar Dp16 mouse strains all develop CHD, which are identifiable by embryonic day 14.5.…”

Section: What We Do Not Knowmentioning

confidence: 97%

See 1 more Smart Citation

New approaches to studying early brain development in Down syndrome

Baburamani

Patkee

Arichi

et al. 2019

Develop Med Child Neuro

View full text Add to dashboard Cite

Down syndrome is the most common genetic developmental disorder in humans and is caused by partial or complete triplication of human chromosome 21 (trisomy 21). It is a complex condition which results in multiple lifelong health problems, including varying degrees of intellectual disability and delays in speech, memory, and learning. As both length and quality of life are improving for individuals with Down syndrome, attention is now being directed to understanding and potentially treating the associated cognitive difficulties and their underlying biological substrates. These have included imaging and postmortem studies which have identified decreased regional brain volumes and histological anomalies that accompany early onset dementia. In addition, advances in genome‐wide analysis and Down syndrome mouse models are providing valuable insight into potential targets for intervention that could improve neurogenesis and long‐term cognition. As little is known about early brain development in human Down syndrome, we review recent advances in magnetic resonance imaging that allow non‐invasive visualization of brain macro‐ and microstructure, even in utero. It is hoped that together these advances may enable Down syndrome to become one of the first genetic disorders to be targeted by antenatal treatments designed to ‘normalize’ brain development. What this paper adds Magnetic resonance imaging can provide non‐invasive characterization of early brain development in Down syndrome. Down syndrome mouse models enable study of underlying pathology and potential intervention strategies. Potential therapies could modify brain structure and improve early cognitive levels. Down syndrome may be the first genetic disorder to have targeted therapies which alter antenatal brain development.

show abstract

Section: What We Do Not Knowmentioning

confidence: 86%

Section: What We Do Not Knowmentioning

confidence: 97%

New approaches to studying early brain development in Down syndrome

Baburamani

Patkee

Arichi

et al. 2019

Develop Med Child Neuro

View full text Add to dashboard Cite

show abstract

“…Indeed, prenatally delayed cerebral development and postnatal abnormal cerebral findings, such as white matter injury, leukomalacia and stroke, can be observed frequently (see meta analysis: Mebius et al , 2017 ). Independent of ischaemic brain injury, anisotropy of the white matter microstructure is reduced ( Mulkey, 2014 ; Hagmann et al , 2016 ; Karmacharya et al , 2018 ; Claessens et al , 2019 ) and is associated with decreased oxygen delivery ( Kelly et al , 2019 ). It has been suggested that reduced cerebral oxygen delivery during the third trimester of foetal life and the neonatal period may lead to an undersupply of the vascular-rich sub-ventricular zone, which plays a critical role in neurogenesis and oligodendrocyte myelination.…”

Section: Discussionmentioning

confidence: 99%

Altered white matter microstructure is related to cognition in adults with congenital heart disease

Ehrler

Schlosser

Brugger

et al. 2020

Brain Communications

View full text Add to dashboard Cite

Adults with congenital heart disease are at risk for persisting executive function deficits, which are known to affect academic achievement and quality of life. Alterations in white -matter microstructure are associated with cognitive impairments in adolescents with congenital heart disease. This study aimed to identify microstructural alterations potentially associated with executive function deficits in adults with congenital heart disease. Diffusion tensor imaging and tract-based spatial statistics were conducted in 45 patients (18 females) and 54 healthy controls (26 females) aged 18–32 years. Fractional anisotropy of white matter diffusion was compared between groups and correlated with an executive function score, derived from an extensive neuropsychological test battery. Patients showed widespread bilateral reduction in fractional anisotropy (P < 0.05, multiple comparison corrected) compared to controls. Lower fractional anisotropy was driven by patients with moderate and severe defect complexity (compared to controls: P < 0.001). Executive function scores were lower in patients (P < 0.05) and associated with lower fractional anisotropy in the left superior corona radiata and the corticospinal tract (corrected P < 0.05). Our findings confirm alterations of white matter microstructure in adults with congenital heart disease, mainly in those patients of moderate to severe complexity. These alterations are associated with impairments in executive functioning. A better understanding of the neurocognitive deficits may help counselling and care of patients with congenital heart disease across their lifespan and have the potential to improve their outcome and quality of life.

show abstract

“…The estimated SHARD coefficients can be used to regenerate data with arbitrary sampling, as expected by other models, or used directly in techniques that operate on multi-shell spherical harmonics ( Christiaens, Sunaert, Suetens, Maes, 2017 , Novikov, Veraart, Jelescu, Fieremans, 2018 , Reisert, Kellner, Dhital, Hennig, Kiselev, 2017 ). As such, the reconstructed output data can be passed on to subsequent processing pipelines for subject-level and group-level analysis of tissue miscrostructure and connectivity in the developing brain ( Kelly, Christiaens, Batalle, Makropoulos, Cordero-Grande, Steinweg, O’Muircheartaigh, Khan, Lee, Victor, Alexander, Zhang, Simpson, Hajnal, Edwards, Rutherford, Counsell, 2019 , Pietsch, Christiaens, Hutter, Cordero-Grande, Price, Hughes, Edwards, Hajnal, Counsell, Tournier, 2019 ).…”

Section: Discussionmentioning

confidence: 99%

Scattered slice SHARD reconstruction for motion correction in multi-shell diffusion MRI

et al. 2021

Self Cite

View full text Add to dashboard Cite

Abnormal microstructural development of the cerebral cortex in neonates with congenital heart disease is associated with impaired cerebral oxygen delivery

Abstract: Background -Abnormal macrostructural development of the cerebral cortex has been associated with

Cited by 6 publications

References 62 publications

New approaches to studying early brain development in Down syndrome

New approaches to studying early brain development in Down syndrome

Altered white matter microstructure is related to cognition in adults with congenital heart disease

Scattered slice SHARD reconstruction for motion correction in multi-shell diffusion MRI

Contact Info

Product

Resources

About