Abnormal maternal serum alpha fetoprotein and pregnancy outcome

Zarzour, Steven J.; Gabert, Harvey A.; Diket, Albert L.; Amant, Marshall St.; Miller, Joseph M.

doi:10.1002/(sici)1520-6661(199811/12)7:6<304::aid-mfm9>3.3.co;2-w

Cited by 2 publications

(1 citation statement)

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“…The early developmental malformations reported in the literature were structural in nature, and late-pregnancy complications were directly life-threatening to the fetus and, oftentimes, the mother. Such conditions included severe preeclampsia, premature labor, intrauterine and/or perinatal death, preterm birth, fetal wastage, and trophoblast abnormalities, including placental previa and disruption (88)(89)(90)(91)(92). Nonpathologic elevations of AFP in pregnancy can be the result of physiologic or procedural phenomena such as twining or multiple pregnancy, low birth weight, prematurity, or incorrect gestational age dating (93)(94)(95)(96).…”

Section: Adverse Pregnancy Complications/outcomes Related To Hafpsupporting

confidence: 91%

Physiology of Alpha-Fetoprotein as a Biomarker for Perinatal Distress: Relevance to Adverse Pregnancy Outcome

Mizejewski

2007

Exp Biol Med (Maywood)

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The many physiologic roles of human alpha-fetoprotein (HAFP) and its correlation with perinatal distress/pregnancy outcome are rarely addressed together in the biomedical literature, even though HAFP has long been used as a biomarker for fetal birth defects. Although the well being of the fetus can be monitored by the measurement of gestational age-dependent HAFP in biologic fluid levels (serum, amniotic fluid, urine, and vaginal fluids) throughout pregnancy, the majority of clinical reports reflect largely second trimester and (less likely) first trimester testing due to regulatory clinical restrictions. However, reports of third-trimester and pregnancy term measurement of HAFP levels performed in clinical research and/or investigational settings have gradually increased over the years and have expanded our base knowledge of AFP-associated pregnancy disorders during these stages. The different structural forms of HAFP (isoforms, epitopes, molecular variants, etc.) detected in the various biologic fluid compartments have been limited by antibody recognition of specific epitopic sites developed by the kit manufacturers based on antibody specificity, sensitivity, and precision. Concomitantly, the advances in elucidating the various biologic actions of AFP are opening new vistas toward understanding the physiologic roles of AFP during pregnancy. The present review surveys HAFP as a biomarker for fetal distress during the perinatal period in view of its structural and functional properties. An attempt is then made to relate the AFP fluid levels to adverse pregnancy complications and outcomes. Hence, the present review was divided into two major sections: (I) AFP structure and function considerations and (II) the relationship of AFP levels to the distressed fetus during the third trimester and at term.

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Section: Adverse Pregnancy Complications/outcomes Related To Hafpsupporting

confidence: 91%

Physiology of Alpha-Fetoprotein as a Biomarker for Perinatal Distress: Relevance to Adverse Pregnancy Outcome

Mizejewski

2007

Exp Biol Med (Maywood)

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Is the ratio of maternal serum to amniotic fluid AFP superior to serum levels as a predictor of pregnancy complications?

Sharony

Dayan

Kidron

et al. 2015

Arch Gynecol Obstet

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Our data suggest that the RATIO might serve as a predictor of IUGR and week of delivery. Although the number of patients in the current study was relatively small, the novelty of the proposed simple marker implies that a larger scale study is warranted. Such studies may confirm this finding and a possible advantage of using this RATIO instead of or in addition to MSAFP values for better prediction of pregnancies at risk for PC.

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Abnormal maternal serum alpha fetoprotein and pregnancy outcome

Cited by 2 publications

References 0 publications

Physiology of Alpha-Fetoprotein as a Biomarker for Perinatal Distress: Relevance to Adverse Pregnancy Outcome

Physiology of Alpha-Fetoprotein as a Biomarker for Perinatal Distress: Relevance to Adverse Pregnancy Outcome

Is the ratio of maternal serum to amniotic fluid AFP superior to serum levels as a predictor of pregnancy complications?

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