Is the ratio of maternal serum to amniotic fluid AFP superior to serum levels as a predictor of pregnancy complications?

Sharony, Reuven; Dayan, Danit; Kidron, Debora; Manor, Mira; Berkovitz, Arie; Biron‐Shental, Tal; Maymon, Ron

doi:10.1007/s00404-015-3905-9

Cited by 16 publications

(10 citation statements)

References 11 publications

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“…Prenatal levels in developing human embryo rise from the end of the first trimester and begin to fall after 32 weeks of gestation. Maternal serum AFP forms part of the triple or quadruple screening tests for fetal anomaly [11,12] . The current study revealed that there is adverse pregnancy outcome in which, preeclampsia found in (8%) and IUGR in (4%) with significant increase in serum level of Alpha feto protein in adverse outcome.…”

Section: Discussionmentioning

confidence: 99%

The association of Maternal Alpha fetoprotien and BHCG with umbilical artery pattern in mid trimester

Naeem¹,

Alnakkash²

2021

Int. J. Clin. Obstet. Gynaecol.

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Background: Mid-trimester maternal serum markers have been used for prenatal aneuploidy screening for more than 20 years. In the absence of aneuploidy or neural tube defect, these serum markers have also been associated with several placenta-mediated adverse pregnancy outcomes, including preeclampsia, intrauterine growth restriction, and stillbirth. Objective: To assess the effect of maternal alpha fetoprotein and B-HCG in umbilical artery Doppler change in 2 nd trimester. Patients and Method: An observational prospective cohort study, conducted at Al-Elwiya maternity teaching hospital Obstetrics department, from the first of February 2019 to the end of Jan. 2020. Results: The current study was included 50 patients within the mean age (25.7±6.2) years old and the main age group was between 21-30 years (62.0%), normal pregnancy outcome in (88.0%), while preeclampsia found in 4 (8.0%) patients and IUGR in 2 (4,0%). Significant association were found between elevated level of serum HCG and Alpha feto protein with adverse pregnancy outcome (P=0.005). Conclusion:Alpha feto protein and HCG were not significantly related to Doppler change in the current study.

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Section: Discussionmentioning

confidence: 99%

The association of Maternal Alpha fetoprotien and BHCG with umbilical artery pattern in mid trimester

Naeem¹,

Alnakkash²

2021

Int. J. Clin. Obstet. Gynaecol.

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“…The study of Barta et al speculated that MS-AFP could be used as a marker for determination of fetal condition when following SGA fetuses [25]. Sharony et al [26] recently reported that MS-AFP and amniotic fluid AFP ratio might serve as a predictor of SGA and GA at delivery, and the higher the ratio, the lower the birth weight and GA. Although many of the associations between mid-trimester MS-hCG and/or MS-AFP levels and adverse pregnancy outcomes are statistically significant, the sensitivity and positive predictive value are too low for them to be clinically useful as screening tests.…”

Section: Discussionmentioning

confidence: 99%

Pregnancy outcomes regarding maternal serum AFP value in second trimester screening

Bartkute

Balsyte

Wisser

et al. 2016

Journal of Perinatal Medicine

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“…Ratio of maternal serum alpha fetoprotein (AFP)/amniotic fluid AFP was suggested as a potential predictor for intrauterine growth restriction and preterm delivery in a small sample sized study [ 70 ].…”

Section: Biomarkersmentioning

confidence: 99%

Prediction of Preterm Birth: Maternal Characteristics, Ultrasound Markers, and Biomarkers: An Updated Overview

Kaplan

Özgü-Erdinç

2018

Journal of Pregnancy

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There is not a single or combined screening method for preterm birth with high sensitivity which will truly identify the women at risk for preterm birth while also with high specificity to prevent unnecessary interventions and high treatment costs. Measurement of cervical length is the most cost-effective method that is used in clinical practice. Bedside tests have also been developed for detecting markers like fetal fibronectin, insulin-like growth factor binding protein-1 (IGFBP-1), interleukin-6, and placental alpha-macroglobulin-1. Taking the maternal history, health condition, and sociodemographical factors into consideration is recommended. Ultrasound markers apart from cervical length measurements as uterocervical angle and placental strain ratio are studied. Investigations on metabolomics, proteomics, and microRNA profiling have brought a new aspect on this subject. Maybe in the future, with clear identification of women at true risk for preterm birth, development of more effective preventive strategies will not be unfeasible.

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Is the ratio of maternal serum to amniotic fluid AFP superior to serum levels as a predictor of pregnancy complications?

Cited by 16 publications

References 11 publications

The association of Maternal Alpha fetoprotien and BHCG with umbilical artery pattern in mid trimester

The association of Maternal Alpha fetoprotien and BHCG with umbilical artery pattern in mid trimester

Pregnancy outcomes regarding maternal serum AFP value in second trimester screening

Prediction of Preterm Birth: Maternal Characteristics, Ultrasound Markers, and Biomarkers: An Updated Overview

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