Abnormal liver function in different patients with Schistosoma japonicum

An, Ning; Wu, Xiaoying; Li, Hongyu; Liang, Jinyi; Gao, Zu-Lu; Shen, Jia; Liu, Zhen; Xu, Jun; Hu, Fei; Wu, Feng; Ji, Pengyu; Wu, Zhongdao; Sun, Xiaobai

doi:10.1007/s00436-014-4163-7

Cited by 11 publications

(5 citation statements)

References 14 publications

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“…Previously, it was found that hepatitis B virus infection and schistosomiasis interacted in liver damage [26]. Recent studies have also shown that there was no significant correlation between HBV infection status and the development of CS to AS (ascites type) [27], the correlation analysis of this study further showed that HBV infection in CS cases was not an influencing factor in the development of AS.…”

Section: Discussionsupporting

confidence: 44%

Predicting the Occurrence of Advanced Schistosomiasis Based on FISHER Discriminant Analysis of Hematological Biomarkers

Yang

Xie

et al. 2022

Pathogens

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We established a model that predicts the possibility of chronic schistosomiasis (CS) patients developing into advanced schistosomiasis (AS) patients using special biomarkers that were detected in human peripheral blood. Blood biomarkers from two cohorts (132 CS cases and 139 AS cases) were examined and data were collected and analyzed by univariate and multivariate logistic regression analysis. Fisher discriminant analysis (FDA) for advanced schistosomiasis was established based on specific predictive diagnostic indicators and its accuracy was assessed using data of 109 CS. The results showed that seven indicators including HGB, MON, GLB, GGT, APTT, VIII, and Fbg match the model. The accuracy of the FDA was assessed by cross-validation, and 86.7% of the participants were correctly classified into AS and CS groups. Blood biomarker data from 109 CS patients were converted into the discriminant function to determine the possibility of occurrence of AS. The results demonstrated that the possibility of occurrence of AS and CS was 62.1% and 89.0%, respectively, and the accuracy of the established model was 81.4%. Evidence displayed that Fisher discriminant analysis is a reliable predictive model in the clinical field. It’s an important guide to effectively control the occurrence of AS and lay a solid foundation for achieving the goal of schistosomiasis elimination.

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Section: Discussionsupporting

confidence: 44%

Predicting the Occurrence of Advanced Schistosomiasis Based on FISHER Discriminant Analysis of Hematological Biomarkers

Yang

Xie

et al. 2022

Pathogens

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“…Symptoms correlate with the developmental stages of S. japonicum. The main impact of this disease results from chronic infection and re-infection which may lead to non-fatal but debilitating sequelae such as granulomatous inflammation and fibrosis (Cai et al 2006;Ning et al 2015;Shen et al 2014). Infections with S. japonicum are characterized immunologically by an initial T helper type 1 (Th1) response that switches to a highly Th2-polarized response following the onset of egg production at about 6 weeks post infection (PI) (Grzych et al 1991;Stadecker et al 2004).…”

Section: Introductionmentioning

confidence: 98%

The expression of molecule CD28 and CD38 on CD4+/CD8+ T lymphocytes in thymus and spleen elicited by Schistosoma japonicum infection in mice model

Song

et al. 2015

Parasitol Res

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Schistosomiasis caused by human schistosomes such as Schistosoma japonicum (S. japonicum) is considered as an immune-related disease. It was demonstrated that specific cytokine antibodies' response elicited by S. japonicum infection was gradually downregulated with the progress of the disease, resulting in a Th1/Th2 polarization and suppression of immune response. CD28 (cluster of differentiation 28) is one of the proteins expressed on T cells that provide co-stimulatory signals required for T cell activation and survival, and CD38 is an activating marker of T lymphocyte with high expression in many acute or chronic infections. The immune signature of CD28null T cells in the peripheral circulation associates with chronic inflammation in many diseases, such as HIV and CMV infection. In the thymus, CD28 expression on developing thymocytes appears to play a role for their selection, and it synergizes with CD38 to induce apoptosis of DP (double-positive) thymocytes. Few reports about CD28 and CD38 have been published in schistosomiasis. Here, we investigated the dynamic patterns of the expression of molecules CD28 and CD38 on CD4(+)/CD8(+) T lymphocytes of the thymus and spleen in mice model with S. japonicum infection. Our data indicated that at an early period of infection, the frequency of CD8(+)CD28(-) T cell in the spleen decreased significantly, but higher at chronic infection than that in control. However, it demonstrated an increasing trend in the thymus with the progression of infection. The frequency of CD4(+)CD28(-) T cells increased from acute infection in the thymus, while from chronic infection in the spleen. The expression of CD38 on CD8(+) T cells began to increase at 4 weeks post infection both in the thymus and spleen; its elevated expression on CD4(+) T cells emerged at 6 weeks post infection in the thymus and at 10 weeks post infection in the spleen. Praziquantel (PZQ) treatment could partially restore the frequency of CD28(+) T cell of CD4(+) T cells and CD38(+) T cell of CD8(+)/CD4(+) T cells in the spleen and CD38(+) T cell in the thymus. We hypothesized that the reactivation of S. japonicum infection may trigger expansion of CD28(-) T cells and hence mediate systemic inflammation. We speculated that CD8(+)CD28(-) T cell might be involved in immune modulation and CD8(+)CD28(-) T cell may be a crucial part in pathogenesis, which can provide further knowledge of the sophisticated mechanism of immuno-downregulation in schistosomiasis and potential treatment target.

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“…28,29 Controversies regarding schistosoma-associated liver fibrosis state that coinfection of schistosomiasis with chronic HBV is associated with more severe hepatic fibrosis. [30][31][32][33] Our results indicated that coinfection of schistosomiasis with chronic HBV might result in worse outcomes. CAVIN2 + MP(2) cannot be specifically divided into M1 or M2 due to the low expression of marker genes of M1(TNF, IL1B, IL12B) and M2(ARG1, IL10).…”

Section: Discussionmentioning

confidence: 69%

A preliminary investigation into the immune cell landscape of schistosome‐associated liver fibrosis in humans

Zhou

et al. 2021

Immunol Cell Biol

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Schistosomiasis is a widespread helminth disease that poses a heavy social and economic burden on people worldwide. Advanced schistosomiasis often develops into schistosome-associated liver fibrosis, the pathogenesis of which remains unclear. This study aimed preliminarily to profile immune cells of schistosome-associated liver fibrosis using single-cell RNA sequencing. Three patient groups were enrolled, including an Schistosomiasis japonicum (SJ) group (n = 1), a chronic liver failure (CLF) group (n = 3) and a healthy control (HC) group (n = 2), revealing 17 cell clusters out of 20 093 cells. From these limited datasets, it was observed that T cell-1, mononuclear phagocytes(MP)-1 and dendritic cells (DCs) were higher in the SJ group. CAVIN2 + MP(2) was the predominant cell type in the MP subset of the SJ group (53%), and was higher than that in both the CLF (8%) and HC (1%) groups. Kupffer cell marker genes (CD163, MARCO and TIMD4) were enriched in caveolaeassociated protein 2 (CAVIN2) + MP(2), which was also an important source of TGFB1. The KEGG pathways of CAVIN2 + MP(2) indicated that they were associated with lysosome, endocytosis, phagosome and antigen processing and presentation. The preliminary study showed that granzyme B (GZMB) + T cell (1) and ankyrin repeat domain-containing protein 36B + T cell(3) were the most common T cells in the SJ group (50% and 32%, respectively). The KEGG pathways of GZMB + T cell(1) were mainly related to natural killer cellmediated cytotoxicity. The percentage of ring1 and YY1 binding protein (RYBP) + DC(1) was higher in the SJ group (57%) than in the CLF (16%) and HC (6%) groups. The KEGG pathway of RYBP + DC(1) was related to Fc gamma R-mediated phagocytosis and antigen processing and presentation. Overall, CAVIN2 + Kupffer cells were the main source of TGFB1, consisting primarily of mononuclear phagocytes in the livers of the SJ group subjects and potentially playing an irreplaceable role in hepatic fibrosis of schistosomiasis.

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Abnormal liver function in different patients with Schistosoma japonicum

Cited by 11 publications

References 14 publications

Predicting the Occurrence of Advanced Schistosomiasis Based on FISHER Discriminant Analysis of Hematological Biomarkers

Predicting the Occurrence of Advanced Schistosomiasis Based on FISHER Discriminant Analysis of Hematological Biomarkers

The expression of molecule CD28 and CD38 on CD4+/CD8+ T lymphocytes in thymus and spleen elicited by Schistosoma japonicum infection in mice model

A preliminary investigation into the immune cell landscape of schistosome‐associated liver fibrosis in humans

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