Abnormal intrinsic functional hubs in alcohol dependence: evidence from a voxelwise degree centrality analysis

Luo, Xiaoping; Guo, Linghong; Dai, Xuesong; Wang, Qinglai; Zhu, Wenwu; Miao, Xinjun; Gong, Honghan

doi:10.2147/ndt.s142742

Cited by 63 publications

(80 citation statements)

References 44 publications

(46 reference statements)

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“…1 The group differences in DC between DEACMP patients and healthy controls. Red and blue denote higher and lower DC in patients than in healthy controls areas may be interpreted as an enhanced neural effort to offset structural damage to the brain [26]; the gradual decompensation leads to a reconfiguration of important nodes in the whole network, causing the symptoms to further aggravate, which is a process of continuous progress. Previous studies have reported that limbic systems, such as the hippocampus and cingulate gyrus, are essential for the coordination of information flow throughout the brain network, and lesions in these regions will seriously affect the stability of brain system function [27].…”

Section: Discussionmentioning

confidence: 99%

Abnormal degree centrality in delayed encephalopathy after carbon monoxide poisoning: a resting-state fMRI study

et al. 2020

Neuroradiology

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Purpose To explore neuropathologic mechanisms in functional brain regions in patients with delayed encephalopathy after carbon monoxide poisoning (DEACMP) from the perspective of the brain network nodes by resting-state functional magnetic resonance imaging (rs-fMRI). Methods The fMRI and cognitive assessments were performed in 25 patients with DEACMP and 25 age-, sex-and educationmatched healthy controls (HCs). Data analysis was performed via the degree centrality (DC) method. Then, the associations between the cognitive assessments and DC in the identified abnormal brain regions were assessed by using a correlation analysis. Results Compared with the HCs, the DEACMP patients displayed significantly decreased DC values in the right superior frontal gyrus, right precentral gyrus, right angular gyrus, right marginal gyrus, right hippocampus, and left thalamus but increased DC values in the right inferior frontal gyrus, right cingulate gyrus, left superior temporal gyrus, left medial temporal gyrus, right lingual gyrus, and right posterior cerebellar lobe, pons, and midbrain (GRF correction, voxel P value < 0.001, cluster P value < 0.01). The correlation analysis in the DEACMP group revealed that there was a negative correlation between the DC values in the right hippocampus and MMSE scores, whereas a positive correlation was observed in the right cingulate gyrus. Conclusions Patients with DEACMP exhibited abnormal degree centrality in the brain network. This finding may provide a new approach for examining the neuropathologic mechanisms underlying DEACMP.

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Section: Discussionmentioning

confidence: 99%

Abnormal degree centrality in delayed encephalopathy after carbon monoxide poisoning: a resting-state fMRI study

et al. 2020

Neuroradiology

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“…Interestingly, in the present study we found a strong unilateral lateralization in RRMS, showing that higher, lower, and sum of higher and lower degree centrality value in brain areas between RRMS and HGs consistently showed more numbers of different degree centrality value in brain areas in left than that of right, and more total numbers of voxel volume of different degree centrality value in brain areas in left than that of right. The unilateral lateralization was also found in smoking dependence subjects [23,31], insomnia patients [24,32] and healthy subjects in auditory capability [33] and visual modality [34]. Thus the unilateral lateralization is not unique, it may happen in ill-condition even in normal condition.…”

Section: Researchmentioning

confidence: 86%

“…MRIcro software (www.MRIcro.com) was used to ensure data quality. The first 10 time points of the functional images were discarded due to the possible instability of initial MRI signal and the participants' adaptation to scanning environment [24]. On the basis of MATLAB2010a (Mathworks, Natick, MA, USA), the rest of the data pre-processing was performed by Data Processing & Analysis for Brain Imaging (DPABI 2.1, http://rfmri.org/DPABI) toolbox, including Digital Imaging and Communications in Medicine (DICOM) standards for form transformation, slice timing, head motion correction, spatial normalization, smooth with a Gaussian kernel of 6×6×6 mm3 full-width at half-maximum.…”

Section: Discussionmentioning

confidence: 99%

Abnormal Intrinsic Functional Hubs in Relapsing- Remitting Multiple Sclerosis: Evidence from a Voxel-Wise Degree Centrality Analysis

Chen¹,

Zhang²,

Kong³

et al. 2018

Neuropsychiatry

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Objective: To explore the abnormal intrinsic functional hubs in relapsing-remitting multiple sclerosis (RRMS) using degree centrality approach and their relationships with clinical features. Methods: Total of 26 RRMS (13 males, 13 females; mean age, 35.38 ± 11.33 years) and 27 statusmatched healthy groups (HGs; 12 males, 15 females; mean age, 35.37 ± 11.67 years) were recruited. RRMS underwent a physical examination using Expanded Disability Status Scale (EDSS) by an experienced neurologist. Degree centrality and functional connectivity approach was used to assess the abnormal intrinsic functional hubs features. Partial correlation analysis was conducted to investigate the relationships between clinical features and abnormal functional hubs. Receiver operating characteristic (ROC) curve was applied to calculate the sensitivities and specificities of those altered functional hubs to distinguish RRMS from HGs. Results: Compared with HGs, RRMS exhibited significantly higher degree centrality values in multiple brain areas and lower degree centrality values in bilateral salience network and left cingulate gyrus. Decreased functional connectivity was found within left-right salience network, and between salience network and cingulate gyrus. Duration of disease and EDSS revealed negative correlations with degree centrality value in the salience network. ROC analysis showed good performances of these abnormal hubs in distinguishing RRMS from HGs with high degree of sensitivities and specificities. Conclusions: RRMS is associated with multiple specific abnormal functional hubs including relatively reduced and increased degree centrality value, which expands our understanding of the functional characteristics and may provide a new insight into understanding the pathophysiological mechanisms of RRMS.

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“…The human precuneus is associated with several basic cognitive activities in the resting-state condition. These include the collection and evaluation of information, self-referential mental activity, extraction of episodic memory, emotion, and anxiety [22]. Previous studies have found AUD patients to have impairments in the PCC and precuneus.…”

Section: Discussionmentioning

confidence: 99%

Behavioural cue reactivity to alcohol and non-alcohol-related stimuli among individuals with severe alcohol use disorder: an fMRI study with a visual task

Fukushima

Kuga

Oribe

et al. 2020

Preprint

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Patients with alcohol use disorder (AUD) have difficulties controlling alcohol cravings and thus exhibit increased use and earlier relapse. Although patients tend to respond more strongly to alcohol-related images compared with non-alcohol-related images, few researchers examined the factors that modulate cravings. Here, we examined whole-brain blood oxygen level-dependent (BOLD) responses to behavioural cues in individuals with AUD and healthy controls (HCs). The participants included 24 patients with severe AUD and 15 HCs. We presented four beverage images (juice, drinking juice, sake, and drinking sake) and compared participant BOLD responses between the two groups. Multiple comparisons revealed that the AUD group had lower BOLD responses compared with the HC group to images of drinking juice in the left precuneus (p = 0.036) and the left posterior cingulate cortex (PCC) (p = 0.044) and higher BOLD responses to images of drinking sake in the left PCC (p = 0.044). Furthermore, compared to the HCs, the AUD patients had decreased BOLD responses associated with cue reactivity to drinking juice in the left precuneus during the period from 15 to 18 s (p = 0.004, df = 37) and 18 to 21 s (p = 0.002, df = 37). Using the Spearman correlation, we found a significant negative correlation between BOLD responses in the left PCC of the AUD patients and Mini–Mental State Examination (MMSE) scores (r = −0.619, p = 0.001). Our findings suggest that HCs and severe AUD patients differ in their responses not to images of alcoholic beverages but those related to alcohol drinking behavior. Thus, these patients appear to have different patterns of brain activity. This information may aid clinicians in developing treatments for patients with AUD.

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Abnormal intrinsic functional hubs in alcohol dependence: evidence from a voxelwise degree centrality analysis

Cited by 63 publications

References 44 publications

Abnormal degree centrality in delayed encephalopathy after carbon monoxide poisoning: a resting-state fMRI study

Abnormal degree centrality in delayed encephalopathy after carbon monoxide poisoning: a resting-state fMRI study

Abnormal Intrinsic Functional Hubs in Relapsing- Remitting Multiple Sclerosis: Evidence from a Voxel-Wise Degree Centrality Analysis

Behavioural cue reactivity to alcohol and non-alcohol-related stimuli among individuals with severe alcohol use disorder: an fMRI study with a visual task

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