Abnormal degree centrality in delayed encephalopathy after carbon monoxide poisoning: a resting-state fMRI study

Wu, Kaifu; Li, Meng; He, Laichang; Tan, Yongming

doi:10.1007/s00234-020-02369-0

Cited by 18 publications

(13 citation statements)

References 29 publications

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“…Additional previous studies have found that DC differed between in psychiatric disorders; One study demonstrated that DC changes in the hippocampus are related to delayed encephalopathy after carbon monoxide poisoning (DEACMP). Compared with healthy controls, DEACMP patients with cognition disturbances displayed significantly decreased DC values in the right hippocampus but increased DC values in the right inferior frontal gyrus, which is inconsistent with our results (Wu et al, 2020 ). This inconsistency may be related to differences in characteristics or diseases, but can also indicate that abnormal brain function in the hippocampus may present as changed DC.…”

Section: Discussioncontrasting

confidence: 99%

Alteration of Whole Brain ALFF/fALFF and Degree Centrality in Adolescents With Depression and Suicidal Ideation After Electroconvulsive Therapy: A Resting-State fMRI Study

Huang

et al. 2021

Front. Hum. Neurosci.

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Major depressive disorder (MDD) is one of the most widespread mental disorders and can result in suicide. Suicidal ideation (SI) is strongly predictive of death by suicide, and electroconvulsive therapy (ECT) is effective for MDD, especially in patients with SI. In the present study, we aimed to determine differences in resting-state functional magnetic resonance imaging (rs-fMRI) in 14 adolescents aged 12–17 with MDD and SI at baseline and after ECT. All participants were administered the Hamilton Depression Scale (HAMD) and Beck Scale for Suicide Ideation (BSSI) and received rs-fMRI scans at baseline and after ECT. Following ECT, the amplitude of low frequency fluctuation (ALFF) and fractional ALFF (fALFF) significantly decreased in the right precentral gyrus, and the degree centrality (DC) decreased in the left triangular part of the inferior frontal gyrus and increased in the left hippocampus. There were significant negative correlations between the change of HAMD (ΔHAMD) and ALFF in the right precentral gyrus at baseline, and between the change of BSSI and the change of fALFF in the right precentral gyrus. The ΔHAMD was positively correlated with the DC value of the left hippocampus at baseline. We suggest that these brain regions may be indicators of response to ECT in adolescents with MDD and SI.

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Section: Discussioncontrasting

confidence: 99%

Alteration of Whole Brain ALFF/fALFF and Degree Centrality in Adolescents With Depression and Suicidal Ideation After Electroconvulsive Therapy: A Resting-State fMRI Study

Huang

et al. 2021

Front. Hum. Neurosci.

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“…Third, the statistical correction method we used is a cluster-defining-threshold (CDT) approach, which might import potential false positive rates. However, we set the voxel-level p < 0.001 and cluster-level p < 0.05 as the previous studies used ( Eklund et al, 2016 ; Lin et al, 2019 ; Yang et al, 2019 ; Wang et al, 2020 ; Wu et al, 2020 ) to reduce the false positive rate as much as possible. Future studies are required to verify the results with a larger sample size and different statistical correction methods.…”

Section: Discussionmentioning

confidence: 99%

Levodopa Changes Functional Connectivity Patterns in Subregions of the Primary Motor Cortex in Patients With Parkinson’s Disease

Shen

Chen

et al. 2020

Front. Neurosci.

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Background The primary motor cortex (M1) is a critical node in Parkinson’s disease (PD)-related motor circuitry; however, the functional roles of its subregions are poorly understood. In this study, we investigated changes in the functional connectivity patterns of M1 subregions and their relationships to improved clinical symptoms following levodopa administration. Methods Thirty-six PD patients and 37 healthy controls (HCs) were enrolled. A formal levodopa challenge test was conducted in the PD group, and the Unified Parkinson’s Disease Rating Scale motor section (UPDRS-III) was assessed before (off state) and 1 h after administration of levodopa (on state). The PD group underwent resting-state functional magnetic resonance imaging in both off and on states, whereas the HC group was scanned once. We used the Human Brainnetome Atlas template to subdivide M1 into twelve regions of interest (ROIs). Functional connectivity (FC) was compared between PD on and off states [paired t -test, voxel-level p < 0.001, cluster-level p < 0.05, Gaussian random field (GRF) correction] and between patients and HC (two-sample t -test voxel-level p < 0.001, cluster-level p < 0.05). Correlations between ΔFC (differences in FC between PD off and on states) and clinical symptom improvements were examined. Results There was decreased FC between the right caudal dorsolateral area 6 and the anterior cingulate gyrus (ACC), the right upper limb region and the left medial dorsal thalamus (mdTHA), as well as increased FC between the left tongue and larynx region and the left medial frontal gyrus. ΔFC between the right caudal dorsolateral area 6 and ACC was positively correlated with improvements in UPDRS-III total scores as well as the rigidity (item 22) and bradykinesia (items 23–26 and 31) subscores. ΔFC between the right upper limb region and left thalamus was positively correlated with improvements in the left upper limb tremor (items 20c and 21b) and postural tremor (item 21b) subscores. Conclusions Our results reveal novel information regarding the underlying mechanisms in the motor circuits in the M1 and a promising way to explore the internal function of the M1 in PD patients. Notably, M1 is a potential therapeutic target in PD, and the exploration of its subregions provides a basis and a source of new insights for clinical intervention and precise drug treatment.

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“…The cells release excitatory transmitters, loss of calcium ions, and ultimately activation of the apoptotic cascade of cell activation ( Douglas-Escobar and Weiss, 2015 ). However, more studies have been conducted on delayed encephalopathy following acute CO poisoning ( Hou et al, 2013 ; Lee et al, 2018 ; Wu et al, 2020a , b ), in which the main pathological changes are extensive demyelination of the brain’s white matter, bilateral symmetrical pallidocyte ischemia, and necrosis. There are only a few studies on brain function alterations during the acute phase of CO poisoning ( Dinghua et al, 2013 ).…”

Section: Introductionmentioning

confidence: 99%

Abnormal Brain Functional Network Dynamics in Acute CO Poisoning

et al. 2021

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Aims: Carbon monoxide poisoning is a common condition that can cause severe neurological sequelae. Previous studies have revealed that functional connectivity in carbon monoxide poisoning is abnormal under the assumption that it is resting during scanning and have focused on studying delayed encephalopathy in carbon monoxide poisoning. However, studies of functional connectivity dynamics in the acute phase of carbon monoxide poisoning may provide a more insightful perspective for understanding the neural mechanisms underlying carbon monoxide poisoning. To our knowledge, this is the first study that explores abnormal brain network dynamics in the acute phase of carbon monoxide poisoning.Methods: Combining the sliding window method and k-means algorithm, we identified four recurrent dynamic functional cognitive impairment states from resting-state functional magnetic resonance imaging data from 29 patients in the acute phase of carbon monoxide poisoning and 29 healthy controls. We calculated between-group differences in the temporal properties and intensity of dFC states, and we also performed subgroup analyses to separately explore the brain network dynamics characteristics of adult vs. child carbon monoxide poisoning groups. Finally, these differences were correlated with patients’ cognitive performance in the acute phase of carbon monoxide poisoning and coma duration.Results: We identified four morphological patterns of brain functional network connectivity. During the acute phase of carbon monoxide poisoning, patients spent more time in State 2, which is characterized by positive correlation between SMN and CEN, and negative correlation between DMN and SMN. In addition, the fractional window and mean dwell time of State 2 were positively correlated with coma duration. The subgroup analysis results demonstrated that the acute phase of childhood carbon monoxide poisoning had greater dFNC time variability than adult carbon monoxide poisoning.Conclusion: Our findings reveal that patients in the acute phase of carbon monoxide poisoning exhibit dynamic functional abnormalities. Furthermore, children have greater dFNC instability following carbon monoxide poisoning than adults. This advances our understanding of the pathophysiological mechanisms underlying acute carbon monoxide poisoning.

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Abnormal degree centrality in delayed encephalopathy after carbon monoxide poisoning: a resting-state fMRI study

Cited by 18 publications

References 29 publications

Alteration of Whole Brain ALFF/fALFF and Degree Centrality in Adolescents With Depression and Suicidal Ideation After Electroconvulsive Therapy: A Resting-State fMRI Study

Alteration of Whole Brain ALFF/fALFF and Degree Centrality in Adolescents With Depression and Suicidal Ideation After Electroconvulsive Therapy: A Resting-State fMRI Study

Levodopa Changes Functional Connectivity Patterns in Subregions of the Primary Motor Cortex in Patients With Parkinson’s Disease

Abnormal Brain Functional Network Dynamics in Acute CO Poisoning

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