Abnormal glucose tolerance in Egyptian beta-thalassemic patients: possible association with genotyping

Abstract

Abnormal glucose tolerance is common in multiply transfused beta-thalassemia major patients, which could be attributed to progressive and early loss of beta-cell mass, along with persistent insulin resistance. Chronic hepatitis C may play a role in the development of abnormal glucose tolerance. An association between diabetes and genotyping IVS II nt 745 was found. Patients with this particular genotype are advised to check their blood glucose every 6 months to detect early occurrence of diabetes.

Blood transfusion profile of Beta-Thalassemia Major patients attending a tertiary care hospital

“…The mean age observed in the present study was close to that of Chern et al [4] (14.8 ± 6.9 years) and comparable with the other study from Tehran (15.20 ± 3.1 years) and a study by Khalifa et al [5] (15.9 ± 3.1 years). In a study by Najafipour F et al [6] in Iran reported mean age was 15.62 ± 4.44 with youngest patient being 10 years and oldest being 27 years.…”

“…In a study by Najafipour F et al [6] in Iran reported mean age was 15.62 ± 4.44 with youngest patient being 10 years and oldest being 27 years. In another study by Khalifa et al [5] showed age range of patients to be 10-30 years as compared to the present study where the age range is 10-23 years. In the present study majority of the patients (80%) were males with male to female ratio of 4:1.…”

“…In the present study majority of the patients (80%) were males with male to female ratio of 4:1. Similarly, study done by Khalifa et al [5] showed majority of patients were males. The sex distribution pattern observed in the present study was similar to other studies from Kolkata [7] and Rawalpindi.…”

Diabetes Mellitus and Impaired Glucose Tolerance in β-Thalassaemia Major Patients with Secondary Haemchromatosis: Frequency and their Associations from a Developing Country

“…Similar findings were observed in another study [34]. Higher age was reported in few studies [25][26][27][28][29]. The probable reasons of patients presented at higher age in these studies were that they enrolled the patients with advance age or their patients have received fewer blood transfusions as compare to our study so as the complications of iron overload may have manifested in advance age group.…”

“…Our findings are comparable to those explained [25] in Iran. However, higher frequencies were reported in India [26], in Egypt [27], in Cyprus [28], in Oman [29] and in Tehran [30]. Poor iron chelation could be the most likely cause.…”