Abnormal Glucose Regulation Is Associated With Lipid-Rich Coronary Plaque

Abstract

Coronary lesions in patients with AGR are associated with more lipid-rich plaque content, which may be related to the increased IR in these patients.

Glycemic Variability on Continuous Glucose Monitoring System Correlates With Non-Culprit Vessel Coronary Plaque Vulnerability in Patients With First-Episode Acute Coronary Syndrome – Optical Coherence Tomography Study –

“…32 Amano et al also reported that coronary lesions in patients with impaired glucose metabolism are associated with greater lipid-rich plaque content. 33 The present finding of an association between high MAGE and TCFA at the non-culprit plaque in patients with mild-moderate stenosis, is consistent with the aforementioned studies. In addition, GV has a more specific triggering effect on oxidative stress than sustained hyperglycemia.…”

Lipid-Rich Plaques Predict Non-Target-Lesion Ischemic Events in Patients Undergoing Percutaneous Coronary Intervention

“…Lipid-rich plaques (LRP) were defined as increased lipid volume (> median) and greater lipid content (%LV >49% and %FV <50%), which occurred in the 75 th percentile of %LV and 25 th percentile of %FV in the present study population. 11, 12 The Bland -Altman test was applied to assess concordance of measurements. Multivariate Cox proportional hazards analysis was applied to study the predictors of clinical events adjusting for confounding factors (age, sex and body mass index) and predefined variables.…”

“…11, 12 In conventional IVUS, cross-sectional images were quantified for lumen cross-sectional area (LCSA), external elastic membrane (EEM), cross-sectional area (CSA), and plaque (P) + media (M) cross-sectional area (P + M CSA = EEM CSA -LCSA) using software built into the IVUS system. An eccentricity index of P + M was calculated with the formula of (maximum P + M thickness -minimum P + M thickness)/maximum P + M thickness.…”

Impact of Diabetes Mellitus on Coronary Atherosclerosis and Plaque Composition Under Statin Therapy

“…Amano et al reported that coronary lesions in patients with abnormal glucose metabolism are associated with lipid-rich plaque components on integrated backscatter-IVUS. 19 Furthermore, metabolic syndrome is also associated with lipid-rich plaques. 20 These lipid-rich plaques are associated with the prevalence of acute coronary syndrome.…”