Lipid-Rich Plaques Predict Non-Target-Lesion Ischemic Events in Patients Undergoing Percutaneous Coronary Intervention

Effects of the Addition of Eicosapentaenoic Acid to Strong Statin Therapy on Inflammatory Cytokines and Coronary Plaque Components Assessed by Integrated Backscatter Intravascular Ultrasound

“…40, 41 Measurement of the lipidic components by IB-IVUS has proven useful in both diagnosis 17,42-44 and assessment of the prognosis of coronary plaques as a risk for coronary events. 45, 46 In the present study, we demonstrated that the EPA+strong statin group had a larger decrease in the lipidic components and a hypercholesterolemia were randomized to receive statin alone or statin plus highly purified EPA. At the end of 5 years, those randomized to EPA plus statin showed a 19% lower occurrence of major cardiovascular events.…”

Role of the Low-Density Lipoprotein-Cholesterol/High-Density Lipoprotein-Cholesterol Ratio in Predicting Serial Changes in the Lipid Component of Coronary Plaque

“…9 Furthermore, IB-IVUS imaging of lipid-rich plaque in non-culprit lesions might be a surrogate marker for the development and progression of atherosclerosis and future ischemic events in patients with ACS and SAP. 21 In this study, we evaluated the lipid component of non-culprit lesions in patients with ACS and SAP. Although some studies have reported that non-culprit lesions in ACS patients had more characteristics of vulnerable plaque and were at higher risk for future adverse events compared with plaques in non-ACS patients, 22,23 in the present study, the percentage of the lipid component of coronary plaques at baseline, as well as any changes in this percentage at follow-up, did not differ between patients with and without ACS (Table S1).…”

Impact of Malondialdehyde-Modified Low-Density Lipoprotein on Tissue Characteristics in Patients With Stable Coronary Artery Disease – Integrated Backscatter-Intravascular Ultrasound Study –

“…12, 22 On the other hand, IB-IVUS has been able to quantitatively evaluate lipid content, which has proven useful in the diagnosis 13 and in the assessment of the prognosis of coronary atherosclerosis, as a risk for experiencing a coronary event. 23, 24 It has been reported that the %lipid in patients with an acute coronary event was significantly higher than those in patients without such an event. 23 Furthermore, the PROSPECT study demonstrated that the triad of a TCFA identified by virtual histology-IVUS, a minimal luminal area <4.0 mm 2 and a plaque burden >70% predicted lesion-specific events during 3 years of follow-up.…”