Abnormal glucose metabolism in virus associated sepsis

Zhang, Peng; Pan, Shangwen; Yuan, Shiying; Shang, You; Shu, Huaqing

doi:10.3389/fcimb.2023.1120769

Cited by 3 publications

(2 citation statements)

References 78 publications

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“…Metabolic reprogramming is a crucial process that fuels overactive immune cells [ 29 ]. In the case of severe viral infection and the so-called “cytokine storm”, a potentially life-threatening process, glycolysis plays a crucial role in the hyper-inflammatory response [ 30 ]. The ability to modulate the glycolysis process (to inhibit or stimulate its processing) could be useful for immune response control in various physiological states.…”

Section: Hyper-inflammatory Response—the Potential Of Glycolysis Inhi...mentioning

confidence: 99%

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The Impact of Glycolysis and Its Inhibitors on the Immune Response to Inflammation and Autoimmunity

Pająk,

Zieliński,

Priebe

2024

Molecules

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Glucose metabolism is a crucial biological pathway maintaining the activation of extra- and intracellular signaling pathways involved in the immune response. Immune cell stimulation via various environmental factors results in their activation and metabolic reprogramming to aerobic glycolysis. Different immune cells exhibit cell-type-specific metabolic patterns when performing their biological functions. Numerous published studies have shed more light on the importance of metabolic reprogramming in the immune system. Moreover, this knowledge is crucial for revealing new ways to target inflammatory pathologic states, such as autoimmunity and hyperinflammation. Here, we discuss the role of glycolysis in immune cell activity in physiological and pathological conditions, and the potential use of inhibitors of glycolysis for disease treatment.

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Section: Hyper-inflammatory Response—the Potential Of Glycolysis Inhi...mentioning

confidence: 99%

“…One of the most broadly tested glycolysis inhibitors is D-glucose analog 2-deoxy-D-glucose (2-DG), lacking the -OH group in the C-2 position in the pyranose ring [ 30 ]. 2-DG competes with glucose to bind to transmembrane GLUTs and enter cells.…”

Section: 2-deoxy-d-glucose As An Anti-inflammatory Agentmentioning

confidence: 99%

The Impact of Glycolysis and Its Inhibitors on the Immune Response to Inflammation and Autoimmunity

Pająk,

Zieliński,

Priebe

2024

Molecules

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Impact of the triglyceride-glucose index on 28-day mortality in non-diabetic critically Ill patients with sepsis: a retrospective cohort analysis

Zhang,

Fan,

Wang

et al. 2024

BMC Infect Dis

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Introduction Sepsis is a life-threatening condition that poses a globally high mortality rate. Identifying risk factors is crucial. Insulin resistance and the TYG index, associated with metabolic disorders, may play a role. This study explores their correlation with mortality in non-diabetic septic patients. Methods This retrospective cohort study used data from the MIMIC-IV (version 2.1) database, which includes over 50,000 ICU admissions from 2008 to 2019 at Beth Israel Deaconess Medical Center in Boston. We included adult patients with sepsis who were admitted to the intensive care unit in the study. The primary outcome was to evaluate the ability of TYG to predict death at 28-day of hospital admission in patients with sepsis. Results The study included 2213 patients with sepsis, among whom 549 (24.8%) died within 28 days of hospital admission. We observed a non-linear association between TYG and the risk of mortality. Compared to the reference group (lower TYG subgroup), the 28-day mortality increased in the higher TYG subgroup, with a fully adjusted hazard ratio of 2.68 (95% CI: 2.14 to 3.36). The area under the curve (AUC) for TYG was 67.7%, higher than for triglycerides alone (AUC = 64.1%), blood glucose (AUC = 62.4%), and GCS (AUC = 63.6%), and comparable to SOFA (AUC = 69.3%). The final subgroup analysis showed no significant interaction between TYG and each subgroup except for the COPD subgroup (interaction P -values: 0.076–0.548). Conclusion In our study, TYG can be used as an independent predictor for all-cause mortality due to sepsis within 28 days of hospitalization. Supplementary Information The online version contains supplementary material available at 10.1186/s12879-024-09711-4.

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Maternal consumption of fish oil protected breast-fed piglets against Escherichia coli lipopolysaccharide-induced damage through reshaping of intestinal fatty acids profile

Fang,

Zhao,

Huo

et al. 2024

Front. Vet. Sci.

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It has been well documented that n-3 polyunsaturated fatty acids (n-3 PUFA) can alleviate inflammation caused by Escherichia coli (E. coli) lipopolysaccharides (LPS), the etiologic agents that causing yellow or white dysentery in young pigs. However, it remains unclear whether the increase in n-3 PUFA availability could enhance the ability of nursery pigs to resist invasion by E. coli. LPS. Twenty-four 21-day-old female piglets, each two of them from the same sow fed the beef tallow (BT) or fish oil (FO) diets, were allocated into four treatment groups: BT-CON, piglets from the BT-fed sows and intraperitoneally injected with saline (9 g/L); BT-LPS, piglets from the BT-fed sows and injected with LPS (100 μg/kg body weight); FO-CON, piglets from the FO-fed sows and injected with saline; FO-LPS, piglets from the FO-fed sows and injected with LPS. Following 2 h of LPS challenge, the magnitudes of increase in body temperature approached to a marked (p < 0.01) difference between the BT-CON and BT-LPS piglets, whereas the dramatic (p < 0.01) difference between the FO-CON and FO-LPS piglets was only observed at 4 h post LPS challenge. The body temperature averaged across the time points evaluated was about 0.2°C lower (p < 0.05) in the FO group than in the BT group. The FO group had lower (p < 0.05) mean corpuscular hemoglobin concentration, lower increase in serum interleukin (IL)-1β (p < 0.10) and IL-8 (p < 0.05) levels, higher (p < 0.01) serum albumin concentration, and higher (p = 0.10) ratios of jejunum villus height to crypt depth than the BT group. The FO group had much higher (p < 0.0001) ileal content of C20:5n3, C24:0, and C22:6n3, which were 2–4 times the content of the BT group. LPS challenge resulted in decreased (p < 0.05) intestinal C20:1 and C20:5n3 content, and the decrease (p < 0.05) in intestinal C20:3n6 and C24:1 content was observed in the BT-LPS piglets rather than in the FO-LPS piglets. Taken together, this study indicated that maternal consumption of fish oil protected breast-fed piglets against E. coli LPS-induced damage through reshaping of intestinal fatty acids profile, which sheds new light on the development of nutritional strategies to enhance the ability of young pigs to resist E. coli invasion.

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Abnormal glucose metabolism in virus associated sepsis

Cited by 3 publications

References 78 publications

The Impact of Glycolysis and Its Inhibitors on the Immune Response to Inflammation and Autoimmunity

The Impact of Glycolysis and Its Inhibitors on the Immune Response to Inflammation and Autoimmunity

Impact of the triglyceride-glucose index on 28-day mortality in non-diabetic critically Ill patients with sepsis: a retrospective cohort analysis

Maternal consumption of fish oil protected breast-fed piglets against Escherichia coli lipopolysaccharide-induced damage through reshaping of intestinal fatty acids profile

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