Abnormal functional network of the thalamic subregions in adult patients with obsessive-compulsive disorder

Li, Kun; Zhang, Haisan; Yang, Yongfeng; Zhu, Jianli; Bi, Wang; Shi, Yanli; Li, Xianrui; Zhang, Meng; Lv, Luxian; Zhang, Hongxing

doi:10.1016/j.bbr.2019.111982

Cited by 29 publications

(21 citation statements)

References 57 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Interestingly, our results were more in line with previous connectivity studies using resting‐state functional imaging in patients with OCD. For example, functional connectivity alterations in OCD have been found between the caudate and temporo‐occipital regions 60‐62 and between the thalamus and occipital cortex 63‐65 . Speculatively, our findings of reduced structural connectivity between occipital and subcortical structures might be associated with visuospatial deficits, which are observed in patients with OCD 66‐70 .…”

Section: Discussionmentioning

confidence: 52%

White matter microstructure and connectivity in patients with obsessive‐compulsive disorder and their unaffected siblings

Dikmeer

Beşiroğlu

Biase

et al. 2020

Acta Psychiatr Scand

View full text Add to dashboard Cite

ObjectiveWe aimed to examine white matter microstructure and connectivity in individuals with obsessive–compulsive disorder (OCD) and their unaffected siblings, relative to healthy controls.MethodsDiffusion‐weighted magnetic resonance imaging (dMRI) scans were acquired in 30 patients with OCD, 21 unaffected siblings, and 31 controls. We examined white matter microstructure using measures of fractional anisotropy (FA), radial diffusivity (RD), and axial diffusivity (AD). Structural networks were examined using network‐based statistic (NBS).ResultsCompared to controls, OCD patients showed significantly reduced FA and increased RD in clusters traversing the left forceps minor, inferior fronto‐occipital fasciculus, anterior thalamic radiation, and cingulum. Furthermore, the OCD group displayed significantly weaker connectivity (quantified by the streamline count) compared to controls in the right hemisphere, most notably in edges connecting subcortical structures to temporo‐occipital cortical regions. The sibling group showed intermediate streamline counts, FA and RD values between OCD and healthy control groups in connections found to be abnormal in patients with OCD. However, these reductions did not significantly differ compared to controls.ConclusionTherefore, siblings of OCD patients display intermediate levels in dMRI measures of microstructure and connectivity, suggesting white matter abnormalities might be related to the familial predisposition for OCD.

show abstract

Section: Discussionmentioning

confidence: 52%

White matter microstructure and connectivity in patients with obsessive‐compulsive disorder and their unaffected siblings

Dikmeer

Beşiroğlu

Biase

et al. 2020

Acta Psychiatr Scand

View full text Add to dashboard Cite

show abstract

“…FC patterns at a resting state display a temporal correlation and provide the communication and interaction between spatially separated brain regions [10]. Previous studies applied a region-of-interest (ROI) approach to investigate the FC alterations in given brain regions at rest in OCD with inconsistent results [11][12][13]. The ROI analysis estimates the strength and significant series of correlations between a given brain region and all other brain regions.…”

Section: Introductionmentioning

confidence: 99%

Altered Functional Connectivity Strength at Rest in Medication-Free Obsessive-Compulsive Disorder

Wang

et al. 2021

Neural Plasticity

View full text Add to dashboard Cite

Background. Previous studies explored the whole-brain functional connectome using the degree approach in patients with obsessive-compulsive disorder (OCD). However, whether the altered degree values can be used to discriminate OCD from healthy controls (HCs) remains unclear. Methods. A total of 40 medication-free patients with OCD and 38 HCs underwent a resting-state functional magnetic resonance imaging (rs-fMRI) scan. Data were analyzed with the degree approach and a support vector machine (SVM) classifier. Results. Patients with OCD showed increased degree values in the left thalamus and left cerebellum Crus I and decreased degree values in the left dorsolateral prefrontal cortex, right precuneus, and left postcentral gyrus. SVM classification analysis indicated that the increased degree value in the left thalamus is a marker of OCD, with an acceptable accuracy of 88.46%, sensitivity of 87.50%, and specificity of 89.47%. Conclusion. Altered degree values within and outside the cortical-striatal-thalamic-cortical (CSTC) circuit may cocontribute to the pathophysiology of OCD. Increased degree values of the left thalamus can be used as a future marker for OCD understanding-classification.

show abstract

“…The Brainnetome Atlas template utilized the differences in the structural connection pattern of each voxel [diffusion tensor imaging (DTI) for fiber tracking] and aggregated the voxels with the same connection patterns by a clustering algorithm to complete the definition of brain region boundary ( Fan et al, 2016 ; Paxinos, 2016 ). In other studies, this template has provided a more detailed understanding of the differences in functional connectivity in different subregions of brain areas, such as the thalamus ( Li et al, 2019 ) and Broca’s area ( Zhang et al, 2017 ). Rs-fMRI is a non-invasive method to investigate brain activity and neural network connectivity ( Fox and Greicius, 2010 ; Prodoehl et al, 2014 ).…”

Section: Introductionmentioning

confidence: 99%

Levodopa Changes Functional Connectivity Patterns in Subregions of the Primary Motor Cortex in Patients With Parkinson’s Disease

Shen

Chen

et al. 2020

Front. Neurosci.

View full text Add to dashboard Cite

Background The primary motor cortex (M1) is a critical node in Parkinson’s disease (PD)-related motor circuitry; however, the functional roles of its subregions are poorly understood. In this study, we investigated changes in the functional connectivity patterns of M1 subregions and their relationships to improved clinical symptoms following levodopa administration. Methods Thirty-six PD patients and 37 healthy controls (HCs) were enrolled. A formal levodopa challenge test was conducted in the PD group, and the Unified Parkinson’s Disease Rating Scale motor section (UPDRS-III) was assessed before (off state) and 1 h after administration of levodopa (on state). The PD group underwent resting-state functional magnetic resonance imaging in both off and on states, whereas the HC group was scanned once. We used the Human Brainnetome Atlas template to subdivide M1 into twelve regions of interest (ROIs). Functional connectivity (FC) was compared between PD on and off states [paired t -test, voxel-level p < 0.001, cluster-level p < 0.05, Gaussian random field (GRF) correction] and between patients and HC (two-sample t -test voxel-level p < 0.001, cluster-level p < 0.05). Correlations between ΔFC (differences in FC between PD off and on states) and clinical symptom improvements were examined. Results There was decreased FC between the right caudal dorsolateral area 6 and the anterior cingulate gyrus (ACC), the right upper limb region and the left medial dorsal thalamus (mdTHA), as well as increased FC between the left tongue and larynx region and the left medial frontal gyrus. ΔFC between the right caudal dorsolateral area 6 and ACC was positively correlated with improvements in UPDRS-III total scores as well as the rigidity (item 22) and bradykinesia (items 23–26 and 31) subscores. ΔFC between the right upper limb region and left thalamus was positively correlated with improvements in the left upper limb tremor (items 20c and 21b) and postural tremor (item 21b) subscores. Conclusions Our results reveal novel information regarding the underlying mechanisms in the motor circuits in the M1 and a promising way to explore the internal function of the M1 in PD patients. Notably, M1 is a potential therapeutic target in PD, and the exploration of its subregions provides a basis and a source of new insights for clinical intervention and precise drug treatment.

show abstract

Abnormal functional network of the thalamic subregions in adult patients with obsessive-compulsive disorder

Cited by 29 publications

References 57 publications

White matter microstructure and connectivity in patients with obsessive‐compulsive disorder and their unaffected siblings

White matter microstructure and connectivity in patients with obsessive‐compulsive disorder and their unaffected siblings

Altered Functional Connectivity Strength at Rest in Medication-Free Obsessive-Compulsive Disorder

Levodopa Changes Functional Connectivity Patterns in Subregions of the Primary Motor Cortex in Patients With Parkinson’s Disease

Contact Info

Product

Resources

About