Altered Functional Connectivity Strength at Rest in Medication-Free Obsessive-Compulsive Disorder

Lv, Dan; Ou, Yangpan; Wang, Yuhua; Ma, Jidong; Zhan, Chuang; Yang, Ru; Chen, Yunhui; Shang, Tinghuizi; Jia, Chunman; Sun, Li; Zhang, Guangfeng; Sun, Zimin; Li, Jinyang; Wang, Xiaoping; Guo, Wenbin; Li, Ping

doi:10.1155/2021/3741104

Cited by 10 publications

(4 citation statements)

References 68 publications

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“…Consistent with previous results [ 38 , 39 ], higher lpFCs in the left thalamus and right thalamus/caudate were observed in the current study. As a motor and sensory pathway and an important part of the cortical–striatal–thalamic–cortical (CSTC) circuit, the thalamus/caudate plays a crucial role in the regulation of behavior and cognition [ 40 , 41 ].…”

Section: Discussionsupporting

confidence: 94%

Anatomical distance affects functional connectivity at rest in medicine-free obsessive–compulsive disorder

Chen

et al. 2022

BMC Psychiatry

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Background Brain functional abnormalities at rest have been observed in obsessive–compulsive disorder (OCD). However, whether and how anatomical distance influences functional connectivity (FC) at rest is ambiguous in OCD. Methods Using resting-state functional magnetic resonance imaging data, we calculated the FC of each voxel in the whole-brain and divided FC into short- and long-range FCs in 40 medicine-free patients with OCD and 40 healthy controls (HCs). A support vector machine (SVM) was used to determine whether the altered short- and long-range FCs could be utilized to distinguish OCD from HCs. Results Patients had lower short-range positive FC (spFC) and long-range positive FC (lpFC) in the left precentral/postcentral gyrus (t = -5.57 and -5.43; P < 0.05, GRF corrected) and higher lpFC in the right thalamus/caudate, left thalamus, left inferior parietal lobule (IPL) and left cerebellum CrusI/VI (t = 4.59, 4.61, 4.41, and 5.93; P < 0.05, GRF corrected). Furthermore, lower spFC in the left precentral/postcentral gyrus might be used to distinguish OCD from HCs with an accuracy of 80.77%, a specificity of 81.58%, and a sensitivity of 80.00%. Conclusion These findings highlight that anatomical distance has an effect on the whole-brain FC patterns at rest in OCD. Meanwhile, lower spFC in the left precentral/postcentral gyrus might be applied in distinguishing OCD from HCs.

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Section: Discussionsupporting

confidence: 94%

Anatomical distance affects functional connectivity at rest in medicine-free obsessive–compulsive disorder

Chen

et al. 2022

BMC Psychiatry

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“…Previous studies have reported increased FC in the thalamus at rest ( 66 , 67 ). The increased FC of the thalamus is often interpreted as a compensatory brain activity that activates connected brain regions and enhances the ability of information integration ( 68 ). Recent studies have also shown increased FC between the regions of the FPN (DLPFC) and the thalamus in OCD and their first-degree relatives, in line with the findings in our meta-analysis.…”

Section: Discussionmentioning

confidence: 99%

Convergent functional change of frontoparietal network in obsessive-compulsive disorder: a voxel-based meta-analysis

Yu,

Xu,

et al. 2024

Front. Psychiatry

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BackgroundObsessive-compulsive disorder (OCD) is a chronic psychiatric illness with complex clinical manifestations. Cognitive dysfunction may underlie OC symptoms. The frontoparietal network (FPN) is a key region involved in cognitive control. However, the findings of impaired FPN regions have been inconsistent. We employed meta-analysis to identify the fMRI-specific abnormalities of the FPN in OCD.MethodsPubMed, Web of Science, Scopus, and EBSCOhost were searched to screen resting-state functional magnetic resonance imaging (rs-fMRI) studies exploring dysfunction in the FPN of OCD patients using three indicators: the amplitude of low-frequency fluctuation/fractional amplitude of low-frequency fluctuation (ALFF/fALFF), regional homogeneity (ReHo) and functional connectivity (FC). We compared all patients with OCD and control group in a primary analysis, and divided the studies by medication in secondary meta-analyses with the activation likelihood estimation (ALE) algorithm.ResultsA total of 31 eligible studies with 1359 OCD patients (756 men) and 1360 healthy controls (733 men) were included in the primary meta-analysis. We concluded specific changes in brain regions of FPN, mainly in the left dorsolateral prefrontal cortex (DLPFC, BA9), left inferior frontal gyrus (IFG, BA47), left superior temporal gyrus (STG, BA38), right posterior cingulate cortex (PCC, BA29), right inferior parietal lobule (IPL, BA40) and bilateral caudate. Additionally, altered connectivity within- and between-FPN were observed in the bilateral DLPFC, right cingulate gyrus and right thalamus. The secondary analyses showed improved convergence relative to the primary analysis.ConclusionOCD patients showed dysfunction FPN, including impaired local important nodal brain regions and hypoconnectivity within the FPN (mainly in the bilateral DLPFC), during the resting state. Moreover, FPN appears to interact with the salience network (SN) and default mode network (DMN) through pivotal brain regions. Consistent with the hypothesis of fronto-striatal circuit dysfunction, especially in the dorsal cognitive circuit, these findings provide strong evidence for integrating two pathophysiological models of OCD.

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“…(2015) found that ReHo values increase in the right precuneus and decrease in the right PCC of patients with OCD. In addition, the FC, NH values, and GSR decrease in the PCC/PCu of patients with OCD (Chen et al., 2019; Lv et al., 2021; Peng, Xu, et al., 2014). In line with a study (Kraus et al., 2014) that found increased GMV and FC within the PCC/PCu after SSRI treatment, the present study found that the VMHC values of the bilateral PCC/PCu increase and that OCD clinical symptoms improve during treatment, suggesting the important role of the PCC/PCu in the therapeutic effects of SSRIs.…”

Section: Discussionmentioning

confidence: 99%

Altered interhemispheric functional connectivity in patients with obsessive‐compulsive disorder and its potential in therapeutic response prediction

Yan,

Zhang,

Shan

et al. 2023

J of Neuroscience Research

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The trajectory of voxel‐mirrored homotopic connectivity (VMHC) after medical treatment in obsessive‐compulsive disorder (OCD) and its value in prediction of treatment response remains unclear. This study aimed to investigate the pathophysiological mechanism of OCD, as well as biomarkers for prediction of pharmacological efficacy. Medication‐free patients with OCD and healthy controls (HCs) underwent magnetic resonance imaging. The patients were scanned again after a 4‐week treatment with paroxetine. The acquired data were subjected to VMHC, support vector regression (SVR), and correlation analyses. Compared with HCs (36 subjects), patients with OCD (34 subjects after excluding two subjects with excessive head movement) exhibited significantly lower VMHC in the bilateral superior parietal lobule (SPL), postcentral gyrus, and calcarine cortex, and VMHC in the postcentral gyrus was positively correlated with cognitive function. After treatment, the patients showed increased VMHC in the bilateral posterior cingulate cortex/precuneus (PCC/PCu) with the improvement of symptoms. SVR results showed that VMHC in the postcentral gyrus at baseline could aid to predict a change in the scores of OCD scales. This study revealed that SPL, postcentral gyrus, and calcarine cortex participate in the pathophysiological mechanism of OCD while PCC/PCu participate in the pharmacological mechanism. VMHC in the postcentral gyrus is a potential predictive biomarker of the treatment effects in OCD.

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Altered Functional Connectivity Strength at Rest in Medication-Free Obsessive-Compulsive Disorder

Cited by 10 publications

References 68 publications

Anatomical distance affects functional connectivity at rest in medicine-free obsessive–compulsive disorder

Anatomical distance affects functional connectivity at rest in medicine-free obsessive–compulsive disorder

Convergent functional change of frontoparietal network in obsessive-compulsive disorder: a voxel-based meta-analysis

Altered interhemispheric functional connectivity in patients with obsessive‐compulsive disorder and its potential in therapeutic response prediction

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