Abnormal functional connectivity within resting-state networks is related to rTMS-based therapy effects of treatment resistant depression: A pilot study

Ge, Ruiyang; Blumberger, Daniel M.; Downar, Jonathan; Daskalakis, Zafiris J.; Dipinto, Adam A.; Tham, Joseph; Lam, Raymond W.; Vila‐Rodriguez, Fidel

doi:10.1016/j.jad.2017.04.060

Cited by 66 publications

(51 citation statements)

References 54 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Employing a data-driven multivariate approach, we recently reported that nonresponders displayed hypoconnectivity in rACC/ VMPFC (ventromedial prefrontal cortex) within the DMN and that this region exhibited good performance in discriminating the treatment response status of patients [37]. Our current study using an a priori seed-driven approach provides converging evidence for the predictive capability of rACC.…”

Section: Short and Mid-term Brain Function Biomarkers Of Treatment Resupporting

confidence: 51%

Functional connectivity of the anterior cingulate cortex predicts treatment outcome for rTMS in treatment-resistant depression at 3-month follow-up

Downar

Blumberger

et al. 2020

Brain Stimulation

Self Cite

View full text Add to dashboard Cite

Background and objective: Repetitive transcranial magnetic stimulation (rTMS) is a first-line treatment for treatment-resistant depression (TRD). The mechanisms of action of rTMS are not fully understood, and no biomarkers are available to assist in clinical practice to predict response to rTMS. This study aimed to demonstrate that after-rTMS clinical improvement is associated with functional connectivity (FC) changes of the subgenual cingulate cortex (sgACC) and rostral anterior cingulate (rACC), and FC of sgACC and rACC might serve as potential predictors for treatment response. Methods: Resting-state functional magnetic resonance imaging (rs-fMRI) data were collected within 1 week before rTMS initiation in 50 TRD patients to predict subsequent response to rTMS on the left dorsolateral prefrontal cortex (DLPFC). Follow-up rs-fMRI was obtained 12 weeks after completion of rTMS and neural correlates of rTMS in sgACC-and rACC-related FC patterns were compared to before rTMS data and with rs-fMRI from healthy participants. Results: Treatment response was associated with lower FC of sgACC to right DLPFC and higher FC of rACC to left lateral parietal cortex (IPL) measured at baseline. Using sgACC-DLPFC and rACC-IPL connectivity as features, responder-nonresponder classification accuracies of 84% and 76% (end-of-treatment), 88% and 81% (3-month follow-up), respectively were achieved. Longitudinal rs-fMRI data analyses revealed that the hyperconnectivity between sgACC and visual cortex was normalized to a level which was comparable to that of healthy participants. Conclusions: Brain activity patterns in depression are predictive of treatment response to rTMS, and longitudinal change of brain activity in relevant brain circuits after rTMS is associated with treatment response in depression. Target engagement paradigms may offer opportunities to increase the efficacy of rTMS in TRD by optimal selection of patients for treatment. Trial registration: ClinicalTrials.gov Identifiers: NCT01887782 and NCT02800226.

show abstract

Section: Short and Mid-term Brain Function Biomarkers Of Treatment Resupporting

confidence: 51%

Functional connectivity of the anterior cingulate cortex predicts treatment outcome for rTMS in treatment-resistant depression at 3-month follow-up

Downar

Blumberger

et al. 2020

Brain Stimulation

Self Cite

View full text Add to dashboard Cite

show abstract

“…A recent study by Leaver et al (2018) proposed that pretreatment connectivity measures of the DLPFC and SCC predict ECT treatment outcomes. Several studies have also reported functional connectivity changes in response to repetitive TMS (rTMS) in depressed patients (Ge et al, 2017;Kito et al, 2017;Richieri et al, 2017;Du et al, 2018;Iwabuchi et al, 2019). Positive responses to rTMS have been associated with reduced connectivity of the SCC to the DMN (Philip et al, 2018), along with reduced activity of the SCC and connectivity with the DLPFC (Hadas et al, 2019), supporting the hypothesis of altered connectivity in these areas underlying depressive symptoms (Hamilton et al, 2015).…”

Section: Examining Rapid Antidepressant Effects Through Encodingmentioning

confidence: 92%

Encoding, Consolidation, and Renormalization in Depression: Synaptic Homeostasis, Plasticity, and Sleep Integrate Rapid Antidepressant Effects

Rantamäki

Kohtala

2020

Pharmacol Rev

View full text Add to dashboard Cite

Brain and Mind Doctoral Program (S.K.), the Orion Research Foundation (S.K.), and the Emil Aaltonen foundation (S.K.). T.R. and S.K. are listed as coinventors on a patent application, wherein new tools enabling the development of rapid-acting antidepressants and the efficacy monitors thereof are disclosed based on the basic principles of ENCORE-D. T.R. and S.K. have assigned their patent rights to the University of Helsinki but will share a percentage of any royalties that may be received by the University of Helsinki.

show abstract

“…Functional neuroimaging studies have demonstrated that depression is associated with abnormal patterns of activity in prefrontal cortex, including the VMPFC and DLPFC (Downar, Blumberger, & Daskalakis, ; Ge et al., ; Koenigs et al., ). Furthermore, both the VMPFC and DLPFC are critical neural substrates for the pathogenesis of depression with distinct roles respectively (Koenigs et al., ; Koenigs & Grafman, ).…”

Section: Introductionmentioning

confidence: 99%

Impaired neuroplasticity in the prefrontal cortex in depression indexed through paired associative stimulation

et al. 2018

Self Cite

View full text Add to dashboard Cite

show abstract

Abnormal functional connectivity within resting-state networks is related to rTMS-based therapy effects of treatment resistant depression: A pilot study

Cited by 66 publications

References 54 publications

Functional connectivity of the anterior cingulate cortex predicts treatment outcome for rTMS in treatment-resistant depression at 3-month follow-up

Functional connectivity of the anterior cingulate cortex predicts treatment outcome for rTMS in treatment-resistant depression at 3-month follow-up

Encoding, Consolidation, and Renormalization in Depression: Synaptic Homeostasis, Plasticity, and Sleep Integrate Rapid Antidepressant Effects

Impaired neuroplasticity in the prefrontal cortex in depression indexed through paired associative stimulation

Contact Info

Product

Resources

About