Impaired neuroplasticity in the prefrontal cortex in depression indexed through paired associative stimulation

Noda, Yoshihiro; Zomorrodi, Reza; Vila‐Rodriguez, Fidel; Downar, Jonathan; Farzan, Faranak; Cash, Robin; Rajji, Tarek K.; Daskalakis, Zafiris J.

doi:10.1002/da.22738

Cited by 47 publications

(39 citation statements)

References 70 publications

(96 reference statements)

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“…From a more cognitive perspective, it would have been of interest to assess neural plasticity induced in the dorsolateral PFC (DLPFC), a brain region critically involved in the pathophysiology of MDD (Concerto et al, 2015). In line with this, combining EEG and TMS, Noda et al (2018) reported an impaired neuroplasticity in the DLPFC of patients with MDD compared to healthy subjects.…”

Section: Discussionmentioning

confidence: 68%

Impaired Modulation of Corticospinal Excitability in Drug-Free Patients With Major Depressive Disorder: A Theta-Burst Stimulation Study

Vignaud

Damasceno

Poulet

2019

Front. Hum. Neurosci.

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Impaired neural plasticity may be an important mechanism in the pathophysiology of major depressive disorder (MDD). Coupled with electromyography (EMG), repetitive transcranial magnetic stimulation (rTMS) is a useful tool to evaluate corticospinal excitability and cortical neuroplasticity in living humans. The goal of this study was to compare rTMS-induced cortical plasticity changes in patients with MDD and in healthy volunteers. In this single-blind controlled study, 11 drug-free patients with MDD and 11 matched healthy controls were analyzed. Cortical excitability, measured by the amplitude of motor evoked potentials (MEPs) evoked by single-pulse TMS, was assessed before and repeatedly after (for 30 min) participants received a single session of intermittent theta-burst stimulation (iTBS) and continuous TBS (cTBS). rTMS was applied over the left motor cortex using a neuronavigation system. Intensity was set at 80% of the active motor threshold (AMT). A large interindividual variability was observed after both iTBS and cTBS in the two groups. At the group level, we observed impaired iTBS-induced neuroplasticity in patients with MDD compared to that in controls. No differences were observed between the groups regarding cTBS-induced neuroplasticity. Our results suggest impaired long-term potentiation (LTP)-like mechanisms in MDD. Clinical Trial Registration : www.Clinicaltrials.gov , identifier #NCT02438163.

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Section: Discussionmentioning

confidence: 68%

Impaired Modulation of Corticospinal Excitability in Drug-Free Patients With Major Depressive Disorder: A Theta-Burst Stimulation Study

Vignaud

Damasceno

Poulet

2019

Front. Hum. Neurosci.

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“…Studies old [15,16,17] and new [18,19,20] find that depression affects many brain regions. Prominent brain regions with both functional and structural differences in depression are the frontolimbic brain regions such as the amygdala, hypothalamus, and prefrontal cortex (PFC) [21,22] (for review, see References [23,24]). Dysfunctional connectivity between these regions via an amygdala–striatal–pallidial–thalamic–cingulate cortex circuit is also found dysfunctional in depression [14,25].…”

Section: Neurobiology Of Depressionmentioning

confidence: 99%

“…Interestingly, dysfunction, by way of decreased perfusion in the PFC, has been reported in patients who attempted suicide. It is thought this PFC dysfunction might reduce problem-solving ability, increase negative emotions, and, finally, aid suicidal behaviour especially given the role of the orbitofrontal cortex in response inhibition [22,40].…”

Section: The Importance Of the Pfcmentioning

confidence: 99%

What Role Does the Prefrontal Cortex Play in the Processing of Negative and Positive Stimuli in Adolescent Depression?

Kaya

McCabe

2019

Brain Sciences

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This perspective describes the contribution of the prefrontal cortex to the symptoms of depression in adolescents and specifically the processing of positive and negative information. We also discuss how the prefrontal cortex (PFC) activity and connectivity during tasks and at rest might be a biomarker for risk for depression onset in adolescents. We include some of our recent work examining not only the anticipation and consummation of positive and negative stimuli, but also effort to gain positive and avoid negative stimuli in adolescents with depression. We find, using region of interest analyses, that the PFC is blunted in those with depression compared to controls across the different phases but in a larger sample the PFC is blunted in the anticipatory phase of the study only. Taken together, in adolescents with depression there is evidence for dysfunctional PFC activity across different studies and tasks. However, the data are limited with small sample sizes and inconsistent findings. Larger longitudinal studies with more detailed assessments of symptoms across the spectrum are needed to further evaluate the role of the PFC in adolescent depression.

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“…Depressed individuals show reduced PAS in the dorsolateral prefrontal cortex (DLPFC) compared with healthy individuals, suggesting reduced neuro plasticity. 38 Selective serotonin reuptake inhibitors (SSRIs) affect neuroplasticity induced by transcranial direct current stimulation (tDCS), as detected by repetitive TMS (rTMS)-evoked motor cortex responses or PAS responses. [39][40][41] Recently, magnetic seizure therapy has been shown to provoke changes in the excitability of the frontal cortex that correlate with a reduction in suicidal ideation.…”

Section: J Psychiatry Neurosci 2019;44(3)mentioning

confidence: 99%

Adult neuroplasticity: A new “cure” for major depression?

Albert

2019

jpn

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Neuroplasticity involves synaptic reorganization (Box 1) in response to environmental stressors or rewards and is thought to underlie our ability to adjust, learn and remember. 7 However, in mental illness, it is thought that maladaptive plasticity occurs, resulting in persistence of the depressive symptoms, such as rumination, anhedonia and others. 8 By harnessing corrective neuroplasticity (Box 2), it may be possible to reprogram the maladaptive behaviour and produce long-lasting remission. This editorial presents evidence that both pharmacological and brain stimulation antidepressant approaches may act by inducing corrective neuroplasticity to mediate remission. Increasingly, antidepressant effects on neuroplasticity are shown to correlate with behavioural improvement, both in humans 18 and in animal models, 19 raising the possibility that neuroplasticity could provide a new avenue for depression research. However, learning how to harness this capacity to enhance recovery remains a challenge.

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Impaired neuroplasticity in the prefrontal cortex in depression indexed through paired associative stimulation

Abstract: Our findings provide evidence for impaired neuroplasticity in DLPFC in patients with depression compared to healthy subjects. Such findings may ultimately help us understand the pathophysiology of MDD and mechanisms involved in its treatment.

Cited by 47 publications

References 70 publications

Impaired Modulation of Corticospinal Excitability in Drug-Free Patients With Major Depressive Disorder: A Theta-Burst Stimulation Study

Impaired Modulation of Corticospinal Excitability in Drug-Free Patients With Major Depressive Disorder: A Theta-Burst Stimulation Study

What Role Does the Prefrontal Cortex Play in the Processing of Negative and Positive Stimuli in Adolescent Depression?

Adult neuroplasticity: A new “cure” for major depression?

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