Abnormal functional connectivity under somatosensory stimulation in migraine: a multi-frequency magnetoencephalography study

Ren, Jing; Xiang, Jing; Chen, Yueqiu; Li, Feng; Wu, Ting; Shi, Jingping

doi:10.1186/s10194-019-0958-3

Cited by 26 publications

(32 citation statements)

References 53 publications

(57 reference statements)

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“…Some pivotal MRI studies have extended the concept of a neurolimbic‐pain network with structural inter‐connections between a widespread structural brain set of gray matter regions (nodes) by means of white matter paths (edges), known as “connectomes.” These studies, in line with previous electroencephalographic and magnetoencephalographic observations in migraine patients, have consistently reported in these patients an increased global integration and clustering of cortical areas, the first index reflecting the network ability to manage a large flow of information and the second one describing the tendency of nearest nodes to connect to each other and constituting specialized modules 70‐72 . However, the increase of integration and clustering in both cortical networks may provoke an imbalance between the need to invest resources to promote network efficiency and segregation, and the need to minimize the physical and metabolic cost of wiring, due to critical abnormalities in energy metabolism (likely related to mitochondrial energy dysfunction) 73,74 .…”

Section: Findings From Neuroimagingsupporting

confidence: 81%

Migraine as a Cortical Brain Disorder

et al. 2020

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Purpose Migraine is an exclusively human chronic disorder with ictal manifestations characterized by a multifaceted clinical complexity pointing to a cerebral cortical involvement. The present review is aimed to cover the clinical, neuroimaging, and neurophysiological literature on the role of the cerebral cortex in migraine pathophysiology. Overview Converging clinical scenarios, advanced neuroimaging data, and experimental neurophysiological findings, indicate that fluctuating excitability, plasticity, and metabolism of cortical neurons represent the pathophysiological substrate of the migraine cycle. Abnormal cortical responsivity and sensory processing coupled to a mismatch between the brain’s energy reserve and workload may ignite the trigeminovascular system, leading to the migraine attack through the activation of subcortical brain trigeminal and extra‐trigeminal structures, and driving its propagation and maintenance. Discussion The brain cortex emerges as the crucial player in migraine, a disorder lying at the intersection between neuroscience and daily life. Migraine disorder stems from an imbalance in inhibitory/excitatory cortical circuits, responsible for functional changes in the activity of different cortical brain regions encompassing the neurolimbic‐pain network, and secondarily allowing a demodulation of subcortical areas, such as hypothalamus, amygdala, and brainstem nuclei, in a continuous mutual crosstalk.

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Section: Findings From Neuroimagingsupporting

confidence: 81%

Migraine as a Cortical Brain Disorder

et al. 2020

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“…Moreover, evidence suggests atypical sensory processing in the cortex of migraine patients, especially in the somatosensory, visual, and olfactory-related areas [18,19]. The results of a study based on whole-head magnetoencephalography (MEG) showed aberrant functional connectivity between the sensory cortex and the frontal cortex in a group of migraine patients compared to a healthy control group [20]. A similar study with MEG and finger-tapping task indicated motor cortex hyperactivity in a group of migraine patients [21].…”

Section: Introductionmentioning

confidence: 99%

Effectiveness of cathodal tDCS of the primary motor or sensory cortex in migraine: A randomized controlled trial

et al. 2020

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Objectives: Transcranial Direct Current Stimulation (tDCS) is a new technology that is extensively used for migraine treatment. The present study aims to examine the effectiveness of cathodal-tDCS (c-tDCS) in decreasing migraine pain frequency, duration, and intensity at the right primary motor cortex (M 1) or sensory cortex (S 1) in individuals with episodic or chronic migraine. Methods: The present study has a randomized, single-blind, and sham-controlled design. It tests the effectiveness of 22 sessions of c-tDCS (20min/1000 mA) in 45 migraine patients (episodic ¼ 35; chronic ¼ 10/with aura ¼ 28; without aura ¼ 17). Spread over 10 consecutive weeks, the sessions started with three sessions per week and ended with one session per week. Participants were tested at the baseline, at the end of intervention, and at 12-month follow-up. The migraine diagnosis was based on criteria set by International Headache Society (IHS) and patients were allocated to two experimental (n m1 ¼ 15; n s1 ¼ 15) and a sham intervention group (n c ¼ 15). Results: The results of a series of MANCOVAs showed a significant reduction (p < 0.05) in all hypothesized symptoms of migraine pain in both experimental groups compared to the sham intervention group at the posttest and follow-up. Conclusion: The application of c-tDCS to M 1 or S 1 can be used as a technological intervention for the prophylactic and therapeutic treatment of episodic or chronic migraine. Ethical committee registration number: Ir.mums.fm.rec.1396.362.

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“…Functional imaging placed the differences between the two subtypes on new foundations. Such methods were able to detect CSD during the aura phase (3, 10), and also revealed altered responses to sensory (11) or painful stimuli (12–14).…”

Section: Introductionmentioning

confidence: 99%

Altered Resting State Functional Activity and Microstructure of the White Matter in Migraine With Aura

et al. 2019

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Introduction: Brain structure and function were reported to be altered in migraine. Importantly our earlier results showed that white matter diffusion abnormalities and resting state functional activity were affected differently in the two subtypes of the disease, migraine with and without aura. Resting fluctuation of the BOLD signal in the white matter was reported recently. The question arising whether the white matter activity, that is strongly coupled with gray matter activity is also perturbed differentially in the two subtypes of the disease and if so, is it related to the microstructural alterations of the white matter.Methods: Resting state fMRI, 60 directional DTI images and high-resolution T1 images were obtained from 51 migraine patients and 32 healthy volunteers. The images were pre-processed and the white matter was extracted. Independent component analysis was performed to obtain white matter functional networks. The differential expression of the white matter functional networks in the two subtypes of the disease was investigated with dual-regression approach. The Fourier spectrum of the resting fMRI fluctuations were compared between groups. Voxel-wise correlation was calculated between the resting state functional activity fluctuations and white matter microstructural measures.Results: Three white matter networks were identified that were expressed differently in migraine with and without aura. Migraineurs with aura showed increased functional connectivity and amplitude of BOLD fluctuation. Fractional anisotropy and radial diffusivity showed strong correlation with the expression of the frontal white matter network in patients with aura.Discussion: Our study is the first to describe changes in white matter resting state functional activity in migraine with aura, showing correlation with the underlying microstructure. Functional and structural differences between disease subtypes suggest at least partially different pathomechanism, which may necessitate handling of these subtypes as separate entities in further studies.

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Abnormal functional connectivity under somatosensory stimulation in migraine: a multi-frequency magnetoencephalography study

Cited by 26 publications

References 53 publications

Migraine as a Cortical Brain Disorder

Migraine as a Cortical Brain Disorder

Effectiveness of cathodal tDCS of the primary motor or sensory cortex in migraine: A randomized controlled trial

Altered Resting State Functional Activity and Microstructure of the White Matter in Migraine With Aura

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