Altered Resting State Functional Activity and Microstructure of the White Matter in Migraine With Aura

Faragó, Péter; Tóth, Eszter; Kocsis, Krisztián; Kincses, Bálint; Veréb, Dániel; Király, András; Bozsik, Bence; Tajti, János; Párdutz, Árpád; Delia, S.; Vécsei, László; Szabó, Nikoletta; Kincses, Zsigmond Tamás

doi:10.3389/fneur.2019.01039

Cited by 19 publications

(27 citation statements)

References 57 publications

(67 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…With this pattern of thalamocortical connectivity in mind, we may hypothesize that the MRI pattern of normal thalamic microstructure and disrupted thalamocortical relationship detected in our MA patients could be due either to a pure cortical alteration, or to an alteration of thalamocortical fibre bundles. Previous studies in patients with exclusively visual aura showed widespread disruption of white matter fibre bundle architecture [ 8 , 9 , 11 ], which could contribute to the between-network disconnection found in our patients and in those from other research groups [ 12 , 16 ].…”

Section: Discussionsupporting

confidence: 59%

“…Supporting this hypothesis, distinct neurophysiological [ 4 , 5 ] and MRI [ 6 , 7 ] abnormalities of the visual cortex were detected in patients with complex neurological auras where visual symptoms are associated with sensory and/or dysphasic symptoms. In migraine with aura between attacks, without distinction of aura subtypes, previous studies obtained evidence for aberrant thalamic and thalamocortical fiber microstructure [ 8 – 12 ], as well as for abnormal cortical functional connectivity [ 12 – 16 ]. Hence, whether specific thalamo-cortical network abnormalities may exist in patients with complex auras, compared those with purely visual auras, or healthy controls, is a research question of great interest.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Thalamo-cortical networks in subtypes of migraine with aura patients

et al. 2021

View full text Add to dashboard Cite

Background We searched for differences in resting-state functional connectivity (FC) between brain networks and its relationship with the microstructure of the thalamus between migraine with pure visual auras (MA), and migraine with complex neurological auras (MA+), i.e. with the addition of at least one of sensory or language symptom. Methods 3T MRI data were obtained from 20 patients with MA and 15 with MA + and compared with those from 19 healthy controls (HCs). We collected resting state data among independent component networks. Diffusivity metrics of bilateral thalami were calculated and correlated with resting state ICs-Z-scores. Results As compared to HCs, both patients with MA and MA + disclosed disrupted FC between the default mode network (DMN) and the right dorsal attention system (DAS). The MA + subgroup had lower microstructural metrics than both HCs and the MA subgroup, which correlated negatively with the strength of DMN connectivity. Although the microstructural metrics of MA patients did not differ from those of HCs, these patients lacked the correlation with the strength of DAS connectivity found in HCs. Conclusions The present findings suggest that, as far as MRI profiles are concerned, the two clinical phenotypes of migraine with aura have both common and distinct morpho-functional features of nodes in the thalamo-cortical network.

show abstract

Section: Discussionsupporting

confidence: 59%

Section: Introductionmentioning

confidence: 99%

Thalamo-cortical networks in subtypes of migraine with aura patients

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Besides gray matter, conventional functional-MRI (fMRI) can also be used to measure the blood-oxygenlevel-dependent (BOLD) activity fluctuation in the white matter of the brain. To delineate the changes in white matter resting-state functional activity in migraine, Faragó and colleagues performed an independent component analysis [26]. A comparison of the Fourier spectrum of the resting fMRI fluctuations was drawn between 51 migraineurs (18 migraineurs with aura, 33 migraineurs without aura) and 32 healthy volunteers.…”

Section: White Matter Changes Using Fractional Anisotropy and Diffusimentioning

confidence: 99%

“…Hence, they concluded that various pathomechanisms can cause structural and functional differences between migraine subtypes and recommended to consider these subtypes as separate entities in further studies. Due to inadequate sample size and unequal distribution of participants, results were not generalized [26].…”

Section: White Matter Changes Using Fractional Anisotropy and Diffusimentioning

confidence: 99%

Gray and White Matter Changes in Migraineurs: a Review of Literature

Hasan

Waheed

Arif

et al. 2020

SN Compr. Clin. Med.

View full text Add to dashboard Cite

Several neuroimaging studies with advanced techniques have shown changes in gray and white matter in the brain of migraineurs. This narrative review highlights the structural and functional alterations and causality factors of migraine for the introduction of new treatment modalities. PubMed, Google Scholar, and Scopus were searched without any language restriction for the articles depicting gray and white matter changes in migraineurs. Using magnetic resonance imaging scans, multiple studies have demonstrated a reduction in white matter volume and presence of white matter hyperintensities and demyelinated white matter areas, especially in the frontal and parietal lobes. Similarly, voxel-based morphometry analysis has shown a greater reduction in gray matter in the frontal and cingulate cortex of chronic and episodic migraineurs. An overactivation of the frontal and cingulate cortex has been observed during the interictal period. These parts of gray matter are involved in cognitive, emotional, and autonomic aspects of nociception. Moreover, constituents of the limbic system, particularly the thalamus, hippocampus, amygdala, and cingulate gyrus, have also depicted predominant functional disturbances during migraine episodes. Recent studies highlighted a decrease in gray matter volume in the spinal trigeminal nucleus. These findings suggest that such changes might be the reason for dysfunction and pain regulation. Modern neuroimaging thus clearly helps in understanding the pathophysiology of migraine, which calls for novel therapeutic interventions in unresponsive or chronic migraineurs.

show abstract

“…The simplest method is a direct correlation analysis between different modalities. In migraine with aura patients, resting state activity has been found to be correlated with fractional anisotropy and radial diffusivity in the corpus callosum (Faragó et al, 2019). However, note that the whole relationship is not totally resolved, since the correlation method does not analyze covariance patterns between the assessed modalities.…”

Section: Introductionmentioning

confidence: 99%

Multimodal fusion analysis of structural connectivity and gray matter morphology in migraine

Planchuelo‐Gómez

García‐Azorín

Peral

et al. 2020

Human Brain Mapping

View full text Add to dashboard Cite

No specific migraine biomarkers have been found in single‐modality MRI studies. We aimed at establishing biomarkers for episodic and chronic migraine using diverse MRI modalities. We employed canonical correlation analysis and joint independent component analysis to find structural connectivity abnormalities that are related to gray matter morphometric alterations. The number of streamlines (trajectories of estimated fiber‐tracts from tractography) was employed as structural connectivity measure, while cortical curvature, thickness, surface area, and volume were used as gray matter parameters. These parameters were compared between 56 chronic and 54 episodic migraine patients, and 50 healthy controls. Cortical curvature alterations were associated with abnormalities in the streamline count in episodic migraine patients compared to controls, with higher curvature values in the frontal and temporal poles being related to a higher streamline count. Lower streamline count was found in migraine compared to controls in connections between cortical regions within each of the four lobes. Higher streamline count was found in migraine in connections between subcortical regions, the insula, and the cingulate and orbitofrontal cortex, and between the insula and the temporal region. The connections between the caudate nucleus and the orbitofrontal cortex presented worse connectivity in chronic compared to episodic migraine. The hippocampus was involved in connections with higher and lower number of streamlines in chronic migraine. Strengthening of structural networks involving pain processing and subcortical regions coexists in migraine with weakening of cortical networks within each lobe. The multimodal analysis offers a new insight about the association between brain structure and connectivity.

show abstract

Altered Resting State Functional Activity and Microstructure of the White Matter in Migraine With Aura

Cited by 19 publications

References 57 publications

Thalamo-cortical networks in subtypes of migraine with aura patients

Thalamo-cortical networks in subtypes of migraine with aura patients

Gray and White Matter Changes in Migraineurs: a Review of Literature

Multimodal fusion analysis of structural connectivity and gray matter morphology in migraine

Contact Info

Product

Resources

About