Abnormal Fatty Acid Profile of Blood Cell Phospholipids and Dietary Fatty Acid Intake in Patients with Ulcerative Colitis

Consumption of pomegranate juice decreases blood lipid peroxidation and levels of arachidonic acid in women with metabolic syndrome

“…Still, further research is required to elucidate the relationship between polyphenols from pomegranate juice and the modulation of activities of enzymes included in FA synthesis. Arachidonic acid is an immediate precursor of eicosanoides such as leukotriene B4, thromboxane A2 and prostaglandin E2, known as potential mediators of inflammation, vasoconstriction and platelet aggregation . This could be of special importance in subjects with metabolic syndrome, since MS is characterised with ‘low‐grade’ chronic inflammation and enhanced production of pro‐inflammatory factors .…”

“…Arachidonic acid is an immediate precursor of eicosanoides such as leukotriene B4, thromboxane A2 and prostaglandin E2, known as potential mediators of inflammation, vasoconstriction and platelet aggregation. 48 This could be of special importance in subjects with metabolic syndrome, since MS is characterised with 'low-grade' chronic inflammation and enhanced production of pro-inflammatory factors. 49 Consumption of pomegranate juice resulted in a significant increase in the relative amount of total SFA in plasma.…”

Abnormalities in the serum phospholipids fatty acid profile in patients with alcoholic liver cirrhosis - a pilot study

“…(53,54) Generally, the habitual diet of Serbian adults is characterized by a high intake of energy derived from dietary fats, combined with a lower protein and complex carbohydrate intake. (27,28) Dietary n -6/ n -3 PUFA ratio should be maintained between 2.8 and 3.2 in chronic liver disease, (55,56) but this ratio in the patients in our study was 12.2 (10.7 in well-nourished and 14.8 in malnourished patients).…”

“…The clinical significance of low PUFA status is still unknown, although abnormal FA profile may contribute to clinical problems such as itching, pruritus, abnormal perspiration, susceptibility to infection, delayed wound healing, anemia, thrombocytopenia, diminished platelet aggregation, dysfunction in eicosanoid synthesis and diminished immune system status as seen in patients with cirrhosis. (43,65,66) …”

Effects of n-3 Fatty Acids Supplementation on Plasma Phospholipids Fatty Acid Composition in Patients with Obstructive Jaundice- a Pilot Study

“…Immune and reticuloendothelial dysfunction seem to be important in major complications [ 14 ]. A number of clinical intervention studies indicate that n-3 PUFA have anti-inflammatory properties and therefore, might be useful in the management of inflammatory and autoimmune diseases [ 4 , 15 ]. At sufficiently high intakes, long-chain n-3 PUFAs, as found in oily fish and fish oils, decrease the production of inflammatory eicosanoids, cytokines, and reactive oxygen species and the expression of adhesion molecules [ 16 ].…”