Abnormal blood viscosity and haemostasis in long-standing retinal vein occlusion.

Trope, Graham E.; Lowe, G. D. O.; McArdle, B.; Douglas, J T; Forbes, C. D.; Prentice, ColinR.M.; Foulds, Wallace S.

doi:10.1136/bjo.67.3.137

Cited by 106 publications

(59 citation statements)

References 19 publications

(2 reference statements)

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“…Abnormal blood viscosity, platelets, and coagulation have also been suggested to be involved in RVO pathogenesis (Trope et al, 1983). Hematological dysfunction, such as increased plasma fibrinogen and disruption of the thrombosis-fibrinolysis balance, have been implicated in the development of RVO .…”

Section: Risk Factors Of Rvomentioning

confidence: 99%

Retinal Vein Occlusion Induced by a MEK Inhibitor - Impact of Oxidative Stress on the Blood-Retinal Barrier

Yang¹,

Huang²

2012

Oxidative Stress and Diseases

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Section: Risk Factors Of Rvomentioning

confidence: 99%

Retinal Vein Occlusion Induced by a MEK Inhibitor - Impact of Oxidative Stress on the Blood-Retinal Barrier

Yang¹,

Huang²

2012

Oxidative Stress and Diseases

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“…The most acknowledged risk factor is hypertension, followed by cardiovascular disease, diabetes mellitus, and open-angle glaucoma [9,10,11,12,13,14,15,16,17,18]. Other risk factors that have been reported include increased hematocrit and blood viscosity, hyperlipidemias, elevated levels of α 2 -globulin, chronic lung disease, increased body mass index, presence of antiphospholipid antibodies, hyperopia, and pseudoexfoliation syndrome [18,19,20,21,22,23,24,25,26,27]. Major BRVO more frequently involves the temporal sector, especially the superotemporal arcade [3, 4].…”

Section: Definitionmentioning

confidence: 99%

Branch Retinal Vein Occlusion: Classification and Treatment

Parodi

Bandello²

2009

Ophthalmologica

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Branch retinal vein occlusion (BRVO) refers to a heterogeneous group of disorders with different clinical aspects, courses, and probably therapy. Depending on the site of the arteriovenous crossing, we can roughly divide BRVO into 3 main groups: major BRVO, hemispheric retinal vein occlusion, and macular BRVO. Main treatment options include laser treatment, corticosteroid administration, anti-VEGF drugs, and sheathotomy with or without vitrectomy. Laser photocoagulation, as demonstrated by the Branch Vein Occlusion Study, represents the gold standard for the treatment of macular edema and ocular neovascularization following BRVO. The limited functional outcomes achievable by means of laser treatment have prompted researchers to try alternative options, with varying results. The recent introduction of combined therapies for macular edema may provide a superior approach in an attempt to improve and stabilize visual acuity over a long-term follow-up.

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“…Two main hematological disorders in the pathogenesis of BRVO are dysregulation of the thrombosis-fibrinolysis balance and conditions leading to high blood viscosity [36][37][38] . They create more favorable environment to intravenous thrombus formation and venous occlusion.…”

Section: Hematological Disordersmentioning

confidence: 99%