Abnormal Affective Modulation of Somatosensory Brain Processing Among Patients With Fibromyalgia

Montoya, Pedro; Sitges, Carolina; García-Herrera, Manuel; López-Izquierdo, Raúl; Truyols, Magdalena; Blay, Nicole; Collado, Dolores

doi:10.1097/01.psy.0000188401.55394.18

Cited by 98 publications

(83 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Researchers have provided EEG evidence for this early influence of stimulus significance on sensory processes by examining Somatosensory Evoked Potentials (SEPs; Junghofer et al 2001;Keil et al 2003).Early sensory components that occur before 100 ms in the EEG ERP waveform, specifically P50 and N80, are thought to originate from primary sensory cortex regions that are responsive when detecting sensory input (Montoya et al 2005). Importantly, there appear to be threat related differences in these early sensory components.…”

Section: Motivated Attention and Painmentioning

confidence: 98%

The Role of Sleep and Attention in the Etiology and Maintenance of Fibromyalgia

et al. 2011

View full text Add to dashboard Cite

Fibromyalgia (FM) is a prevalent, debilitating condition characterized by widespread, intense pain experienced as emanating from in the muscles, tendons, and ligaments. Other symptoms include disabling fatigue, poor sleep quality, gastrointestinal complaints, cognitive difficulties and often depression. Lack of apparent muscle pathology or other obvious physiological causes of FM pain make the etiology of FM unclear. This manuscript reviews extant FM literature and integrates research on sleep and the burgeoning literature from the domain of cognitive neuroscience to formulate the Sleep and Pain Diatheses (SAPD) model of FM. This model proposes that a wide range of biopsychosocial stressors can set the stage for FM by activating diatheses for sleep disruption and pain sensitivity. Sleep disruption in those most sensitive to pain initiates a cascade of symptoms that are codified as FM. Once this process is initiated, the symptoms of FM are perpetuated and aggravated by increased vigilance to a broad range of threat-related biopsychosocial stimuli. Thus, it is proposed that sleep is integral to the etiology of FM and also energizes a cognitive feedback loop that maintains or amplifies symptom severity over time.

show abstract

Section: Motivated Attention and Painmentioning

confidence: 98%

The Role of Sleep and Attention in the Etiology and Maintenance of Fibromyalgia

et al. 2011

View full text Add to dashboard Cite

show abstract

“…Importantly, high NA appears to be a vulnerability factor for MUS when it interacts with increased self-focused attention (Gendolla et al, 2005), with previous experiences of somatic events and/or with somatic concerns (Bogaerts et al, 2014;Van den Bergh et al, 1997). As trait anxiety is associated with elevated sensitivity to threat (Hariri, 2009;Yiend, 2010) and compromised inhibitory systems for counter-regulating unpleasantness, it is likely that these mechanisms are involved in the association between high trait NA persons and MUS (Bishop, 2009;Montoya et al, 2005;Tillisch et al, 2011;Van Oudenhove and Aziz, 2013). Recently, the concept of central sensitization has been advanced to capture the idea of hyper-responsivity to various somatosensory stimuli in patients with functional somatic syndromes, characterized by elevated threat and salience detection, and a reduced capacity to down-regulate emotional responses (Bourke et al, 2015;Nijs et al, 2012 for reviews).…”

Section: Threat and Negative Affect (Na)mentioning

confidence: 99%

Symptoms and the body: Taking the inferential leap

Bergh

Witthöft

Petersen

et al. 2017

Neuroscience & Biobehavioral Reviews

378

354

View full text Add to dashboard Cite

a b s t r a c tThe relationship between the conscious experience of physical symptoms and indicators of objective physiological dysfunction is highly variable and depends on characteristics of the person, the context and their interaction. This relationship often breaks down entirely in the case of "medically unexplained" or functional somatic symptoms, violating the basic assumption in medicine that physical symptoms have physiological causes. In this paper, we describe the prevailing theoretical approach to this problem and review the evidence pertaining to it. We then use the framework of predictive coding to propose a new and more comprehensive model of the body-symptom relationship that integrates existing concepts within a unifying framework that addresses many of the shortcomings of current theory. We describe the conditions under which a close correspondence between the experience of symptoms and objective physiology might be expected, and when they are likely to diverge. We conclude by exploring some theoretical and clinical implications of this new account.

show abstract

“…Beyond basic principles of aversive brain function, future investigations could use the present findings for neuropsychiatric populations. For instance, though much research has emphasized the impact of cognitive processing abnormalities, there is growing support for focusing more on understanding the interplay between sensorimotor activity and basic emotion circuitry in disorders as apparently disparate as depression or fibromyalgia (Canbeyli, 2010;Montoya et al, 2005). Robustly activating the aversion-related system before using aversive cues as probes may help to identify subtle network differences across individuals, particularly patients showing altered aversion-related processing.…”

Section: Resultsmentioning

confidence: 99%

GABAA Receptors Predict Aversion-Related Brain Responses: An fMRI-PET Investigation in Healthy Humans

Hayes

Duncan

Wiebking

et al. 2013

Neuropsychopharmacol

View full text Add to dashboard Cite

The perception of aversive stimuli is essential for human survival and depends largely on environmental context. Although aversive brain processing has been shown to involve the sensorimotor cortex, the neural and biochemical mechanisms underlying the interaction between two independent aversive cues are unclear. Based on previous work indicating ventromedial prefrontal cortex (vmPFC) involvement in the mediation of context-dependent emotional effects, we hypothesized a central role for the vmPFC in modulating sensorimotor cortex activity using a GABAergic mechanism during an aversive-aversive stimulus interaction. This approach revealed differential activations within the aversion-related network (eg, sensorimotor cortex, midcingulate, and insula) for the aversive-aversive, when compared with the aversive-neutral, interaction. Individual differences in sensorimotor cortex signal changes during the aversiveaversive interaction were predicted by GABA A receptors in both vmPFC and sensorimotor cortex. Together, these results demonstrate the central role of GABA in mediating context-dependent effects in aversion-related processing.

show abstract

Abnormal Affective Modulation of Somatosensory Brain Processing Among Patients With Fibromyalgia

Cited by 98 publications

References 38 publications

The Role of Sleep and Attention in the Etiology and Maintenance of Fibromyalgia

The Role of Sleep and Attention in the Etiology and Maintenance of Fibromyalgia

Symptoms and the body: Taking the inferential leap

GABAA Receptors Predict Aversion-Related Brain Responses: An fMRI-PET Investigation in Healthy Humans

Contact Info

Product

Resources

About