Ability to regulate immunity of mesenchymal stem cells in the treatment of traumatic brain injury

Viet, Quang Hien Nguyen; Nguyen, Viet Quang; Hoang, Duy Minh Le; Thi, Thuy Hoa Phan; Tran, Huu Phuc; Thị, Cẩm Hà Chế

doi:10.1007/s10072-021-05529-z

Cited by 8 publications

(6 citation statements)

References 21 publications

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“…In addition, compared with the control group, the Glasgow score and Health Stroke Scale of the group treated with MSCs increased starting on the seventh day post-TBI. This proved that MSC therapy contributed to the recovery of motor function and consciousness in patients with TBI [ 96 ].…”

Section: The Role Of Mscs In Treating Tbimentioning

confidence: 97%

“…TBI can also cause peripheral inflammation, mainly in the spleen and thymus, which may lead to multiple organ dysfunction and even death. Studies have shown that plasma levels of inflammatory molecules begin to rise 6 hours after TBI and continue to increase [ 96 ]. The release of these inflammatory molecules, including TNF- α , IL-6, and ROS, promotes systemic diseases such as cancer, atherosclerosis, and diabetes.…”

Section: The Role Of Mscs In Treating Tbimentioning

confidence: 99%

“…Combined BM-MSCs and the peroxisome proliferator-activated receptor gamma agonist, pioglitazone [ 109 ] or propranolol [ 103 ] can also enhance anti-inflammatory effects. Several studies have shown that intravenous injection of BM mononuclear cells followed by MSCs improves cognitive function in patients with TBI [ 96 ]. A few studies showed that the reaction of host immune cells to the transplanted MSCs may be harmful [ 110 ].…”

Section: The Role Of Mscs In Treating Tbimentioning

confidence: 99%

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Mesenchymal Stem Cell Therapy: A Potential Treatment Targeting Pathological Manifestations of Traumatic Brain Injury

Zhang

Jiang

Wang

et al. 2022

Oxidative Medicine and Cellular Longevity

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Traumatic brain injury (TBI) makes up a large proportion of acute brain injuries and is a major cause of disability globally. Its complicated etiology and pathogenesis mainly include primary injury and secondary injury over time, which can cause cognitive deficits, physical disabilities, mood changes, and impaired verbal communication. Recently, mesenchymal stromal cell- (MSC-) based therapy has shown significant therapeutic potential to target TBI-induced pathological processes, such as oxidative stress, neuroinflammation, apoptosis, and mitochondrial dysfunction. In this review, we discuss the main pathological processes of TBI and summarize the underlying mechanisms of MSC-based TBI treatment. We also discuss research progress in the field of MSC therapy in TBI as well as major shortcomings and the great potential shown.

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Section: The Role Of Mscs In Treating Tbimentioning

confidence: 97%

Section: The Role Of Mscs In Treating Tbimentioning

confidence: 99%

Section: The Role Of Mscs In Treating Tbimentioning

confidence: 99%

See 1 more Smart Citation

Mesenchymal Stem Cell Therapy: A Potential Treatment Targeting Pathological Manifestations of Traumatic Brain Injury

Zhang

Jiang

Wang

et al. 2022

Oxidative Medicine and Cellular Longevity

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“… 73 Mesenchymal stem cell transplantation has become a potential and safe treatment of choice for traumatic brain injuries because of its anti-inflammatory capability by regulating leukocyte and inflammatory factors such as IL-6, CRP, and TNF-a. 74 , 75 Treatment with mesenchymal stem cell-derived extracellular vesicles greatly increased neurogenesis and neuroplasticity in a pig model of hemorrhagic stroke and traumatic brain damage. 76 Currently, stem cell therapy using mesenchymal stromal cells has been widely investigated in preclinical models and clinical trials for the treatment of several neurological illnesses, including traumatic brain injury.…”

Section: Mesenchymal Stem Cellsmentioning

confidence: 99%

Therapeutic Application of Stem Cells in the Repair of Traumatic Brain Injury

Adugna¹,

Aragie²,

Kibret³

et al. 2022

SCCAA

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Traumatic brain injury is the main cause of injury-related deaths and disabilities throughout the world, which is characterized by a disruption of the normal physiology of the brain following trauma. It can potentially cause severe complications such as physical, cognitive, and emotional impairment. In addition to understanding traumatic brain injury pathophysiology, this review explains the therapeutic potential of stem cells following brain injury in two pathways: response of endogenous neurogenic cells and transplantation of exogenous stem cell therapy. After traumatic brain injuries, clinical evidence indicated that endogenous neural progenitor cells might play an important role in regenerative medicine to treat brain injury. This is due to an increased neurogenic regeneration ability of these cells following brain injury. Besides, exogenous stem cell transplantation has also accelerated immature neuronal development and increased endogenous cellular proliferation in the damaged brain region. Therefore, a better understanding of the endogenous neural stem cell’s regenerative ability and the effect of exogenous stem cells on proliferation and differentiation ability may help researchers to understand how to increase functional recovery and tissue repair following injury.

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“…Based on these findings on immune-related inflammation, the following interventions can be recommended: one, blocking granulocyte infiltration into the brain; two, inhibiting and neutralizing pro-inflammatory and cytokine activity; three, inhibiting microglial activation and ferroptosis; four, blocking pattern recognition receptor activation of the inflammatory complex; five, inhibiting intrinsic and adaptive immune responses; six, preventing trauma systemic reactions after stress. These interventions may improve the prognosis of patients with TBI ( Balu, 2014 ; Viet et al, 2021 ). Generally, the spleen and the brain are not correlated post-trauma.…”

Section: Treatment Of Traumatic Brain Injury-associated Inflammatory ...mentioning

confidence: 99%

Research Progress on the Inflammatory Effects of Long Non-coding RNA in Traumatic Brain Injury

Wang

Ding

et al. 2022

Front. Mol. Neurosci.

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Globally, traumatic brain injury (TBI) is an acute clinical event and an important cause of death and long-term disability. However, the underlying mechanism of the pathophysiological has not been fully elucidated and the lack of effective treatment a huge burden to individuals, families, and society. Several studies have shown that long non-coding RNAs (lncRNAs) might play a crucial role in TBI; they are abundant in the central nervous system (CNS) and participate in a variety of pathophysiological processes, including oxidative stress, inflammation, apoptosis, blood-brain barrier protection, angiogenesis, and neurogenesis. Some lncRNAs modulate multiple therapeutic targets after TBI, including inflammation, thus, these lncRNAs have tremendous therapeutic potential for TBI, as they are promising biomarkers for TBI diagnosis, treatment, and prognosis prediction. This review discusses the differential expression of different lncRNAs in brain tissue during TBI, which is likely related to the physiological and pathological processes involved in TBI. These findings may provide new targets for further scientific research on the molecular mechanisms of TBI and potential therapeutic interventions.

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Ability to regulate immunity of mesenchymal stem cells in the treatment of traumatic brain injury

Cited by 8 publications

References 21 publications

Mesenchymal Stem Cell Therapy: A Potential Treatment Targeting Pathological Manifestations of Traumatic Brain Injury

Mesenchymal Stem Cell Therapy: A Potential Treatment Targeting Pathological Manifestations of Traumatic Brain Injury

Therapeutic Application of Stem Cells in the Repair of Traumatic Brain Injury

Research Progress on the Inflammatory Effects of Long Non-coding RNA in Traumatic Brain Injury

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