Ability of induced corpora lutea to maintain pregnancy in beef cows.

Bridges, Phillip J.; Wright, David J.; Buford, W. I.; Ahmad, Nasim; Hernández–Fonseca, Hugo; McCormick, Michael L.; Schrick, F. N.; Dailey, R. A.; Lewis, P. E.; Inskeep, E. K.

doi:10.2527/2000.78112942x

Cited by 38 publications

(24 citation statements)

References 30 publications

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“…pregnancy following luteectomy or PGF 2a -induced luteal regression [31,32], it is unlikely that the CL secretes anything other than progesterone, which is essential for pregnancy maintenance. Interestingly, the CL on Day 13 of pregnancy in sheep is exposed to higher basal levels of PGF 2a compared with the CL on Day 13 of the cycle [33].…”

mentioning

confidence: 99%

Receptor Transporter Protein 4 (RTP4) in Endometrium, Ovary, and Peripheral Blood Leukocytes of Pregnant and Cyclic Ewes1

Gifford

Assiri

Satterfield

et al. 2008

Biology of Reproduction

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Interferon-tau (IFNT) is secreted by the conceptus trophoblast and signals pregnancy recognition in ruminants. IFNT regulates expression of genes in the endometrium, peripheral blood leukocytes (PBLs), and corpus luteum (CL). Microarray analysis identified that expression of (chemosensory) receptor transporter protein 4 (RTP4) increased in PBLs during early pregnancy in cows. In the present study, we cloned and characterized RTP4 transcription during early pregnancy in ewes. Endometrium, PBLs, and CL were collected on Days 11, 13, and 15 of the cycle and on Days 11, 13, 15, 17, and 19 of pregnancy. Northern blot analysis revealed an expected 1.6-kb mRNA and an unexpected 2.6-kb mRNA. In endometria, RTP4 mRNA levels in cyclic ewes remained low, whereas RTP4 mRNA increased from Day 11 to Day 17 in pregnant ewes. Levels of RTP4 mRNA also increased from Day 15 to Day 19 in CL and PBL samples from pregnant ewes only. The RTP4 mRNA was located in the glandular epithelium, stratum compactum, and caruncular stroma. Ovine glandular epithelial cells were treated with IFNT to determine if IFNT alone could induce RTP4. IFNT increased RTP4 more than 70-fold at 1.5 h after treatment, with maximal induction of nearly 300-fold above values observed in nontreated controls at 6 h after treatment. These results indicate that RTP4 mRNA levels are induced in the ovine endometrium, PBLs, and CL by IFNT during early pregnancy and in cell culture in response to IFNT. If RTP4 expression affects G protein-coupled receptor function, it may be important for establishment of pregnancy in domestic ruminants.

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confidence: 99%

Receptor Transporter Protein 4 (RTP4) in Endometrium, Ovary, and Peripheral Blood Leukocytes of Pregnant and Cyclic Ewes1

Gifford

Assiri

Satterfield

et al. 2008

Biology of Reproduction

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“…This problem has been well documented in cattle (beef and dairy) calving without a CL [10,11,13,14], and although it has been reported that induced luteal tissue was capable of supporting pregnancy in luteoctomized cattle in the absence of maintenance progestin [12,17,18] the success rate was low when the induced luteal tissue was located on the contralateral ovary to the gravid uterine horn [12]. Only one study reports induced luteal tissue doi: 10.7243/2054-3425-2-1 continuing a bovine pregnancy to term [19].…”

Section: Discussionmentioning

confidence: 99%

“…In early studies exploring the effect of CL ablation on bovine pregnancy, maintenance P 4 was administered prior to CL ablation [5,6,7] or simultaneously with CL ablation [8,9,10,11,12]. In the previous cases, pregnancy was maintained until near the end of gestation; however, it is unknown if pregnancy can be maintained when maintenance P 4 is administered after PGF 2α administration.…”

Section: Introductionmentioning

confidence: 99%

“…There have been reports of induction of luteal tissue during early pregnancy in beef cattle, however the induced luteal tissue needed to be ipsilateral to the gravid uterine horn or it was only transient [12,17,18]. Later, it was reported that induced luteal tissue was capable of continuing a pregnancy to term regardless to which ovary produced the luteal tissue [19].…”

Section: Introductionmentioning

confidence: 99%

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Maintenance of Pregnancy in Beef Cattle after a Luteolytic Dose of ProstaglandinF2α

Ferguson¹,

Kesler²,

Godke³

2014

Vet Med Anim Sci

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The increased use of assisted reproductive technologies (ARTs), increase the risks of erroneous prostaglandin F 2α (PGF 2α ) administration. The objective of this study was to determine if pregnancies could be maintained if P 4 was administered after PGF 2α administration. A total of seven pregnant heifers between 30-40 days of gestation and 19 pregnant cows between 30 to 40 (n=12) or 80 to 90 (n=7) days of gestation were used. All females were administered a maintenance dose of P 4 or progestin at either 2, 6, 8, 10, 12 or 18 hours post-PGF 2α for 7 days. A total of 18 of 25 (72%) pregnancies were maintained for a minimum of 7 days. The success rate for cows and heifers receiving P 4 or progestin 2, 6, 10, 12 or 18 hours after PGF 2α was 4/6 (75%), 6/6 (100%), 2/3 (67%), 2/4 (50%), 1/2 (50%) and 3/4 (75%), respectively. Maintenance P 4 or progestin was continued on selected females (12 of the 18) and they were examined via ultrasonography 2 to 3 times weekly until a follicle ≥10 mm developed on the ovary ipsilateral to the gravid uterine horn, at which time hCG (2,500 IU) was administered. Luteal tissue was successfully induced in 10 of the 12 (83%) and 8 of these calved (80%). These results indicate that it is possible to maintain a bovine pregnancy by administering maintenance dose of P 4 from 2 to 18 hours post-PGF 2α .

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“…(2005c) found no effects on subsequent pregnancy losses in cows that were pregnant at the time of treatment. In beef cows without a primary corpus luteum, the ability of corpora lutea to maintain pregnancy was greater when induced after rather than before day 36 of gestation (Bridges et al. 2000).…”

Section: Treatment With Gonadotrophins (Gnrh or Hcg)mentioning

confidence: 99%

Therapeutic Approaches to Pregnancy Loss of Non‐infectious Cause During the Late Embryonic/Early Foetal Period in Dairy Cattle. A Review

Bech-Sàbat

García-Ispierto

Yániz

et al. 2010

Reprod Domestic Animals

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The problem of pregnancy loss during the late embryonic/early foetal period due to non-infectious causes in dairy cattle is on the rise, especially in high milk producing cows. This review discusses recent therapeutic approaches designed to reduce the incidence of early foetal loss. These strategies are based on the fact that low plasma concentrations of progesterone are commonly related to foetal loss. Progesterone supplementation during the late embryonic/early foetal period has proven useful in curtailing losses, mainly in single pregnancies, whereas a more positive effect of treatment with GnRH than progesterone has been found in twin pregnancies. Therapeutics is not necessary in cows with an additional corpus luteum. In practical terms, suggestions include recording the number of embryos and corpora lutea on first pregnancy diagnosis and checking for normal pregnancy progression on day 60 post-insemination.

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Ability of induced corpora lutea to maintain pregnancy in beef cows.

Cited by 38 publications

References 30 publications

Receptor Transporter Protein 4 (RTP4) in Endometrium, Ovary, and Peripheral Blood Leukocytes of Pregnant and Cyclic Ewes1

Receptor Transporter Protein 4 (RTP4) in Endometrium, Ovary, and Peripheral Blood Leukocytes of Pregnant and Cyclic Ewes1

Maintenance of Pregnancy in Beef Cattle after a Luteolytic Dose of ProstaglandinF2α

Therapeutic Approaches to Pregnancy Loss of Non‐infectious Cause During the Late Embryonic/Early Foetal Period in Dairy Cattle. A Review

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