Ability difference of Beluntas Leaf (Pluchea indica L) ethanol extract and avocado leaf (Persea americana Mill) ethanol extract in Inhibiting caries-causing Streptococcus mutans Bacteria Growth

Nahak, Maria Martina; Tedjasulaksana, Regina; Sumerti, Ni Nengah

doi:10.15562/bmj.v6i3.742

Cited by 7 publications

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“…This is supported by the results of phytochemical screening in other studies, which stated that there are alkaloid compounds, steroids as well as saponins in the dried and fresh leaves of Jatropha curcas. [16][17][18] Phenol compounds are known to change the nature of cell proteins and damage cell membranes. Phenolic compounds can be bactericidal as well as bacteriostatic, depending on their concentration.…”

Section: Discussionmentioning

confidence: 99%

Antibacterial Effectiveness of Jatropha Leaf Extract (Jatropha curcas L.) against Aggregatibacter actinomycetemcomitans: In Vitro Study

Lokanata¹,

Molek

Siregar

2023

Bioscmed

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Background: Periodontal disease is one of the most common dental and oral health problems. Periodontal disease is characterized by inflammation as well as damage to the periodontal tissues, including the alveolar bone, cementum, gingiva, and the periodontal ligament. Aggregatibacter actinomycetemcomitans is the dominant bacterium in cases of periodontitis. Jatropha curcas plant is one of the ingredients that has been widely used for traditional medicine in the community, especially for the leaves. This plant is rich in active compounds such as alkaloids, tannins, phenols, flavonoids, and saponins, which are effective against gram-positive and gram-negative bacteria. This study aimed to determine the effectiveness of Jatropha extract (Jatropha curcas L.) as an antibacterial against Aggregatibacter actinomycetemcomitans in vitro. Methods: In vitro experimental studies. A total of 28 petri dishes contained bacterial colonies Aggregatibacter actinomycetemcomitans were used and divided into 7 test groups, treatment, and control groups. Obtained data were analyzed using SPSS program. Results: Jatropha extract treatment group with a concentration of 35% to 65% had optimal antibacterial abilities as the dose increased. This study also showed that at a concentration of 25%, Jatropha curcas extract did not have the antibacterial ability. Conclusion: Jatropha curcas extract has an antibacterial effect as the concentration of the extract increases againts Aggregatibacter actinomycetemcomitans.

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Section: Discussionmentioning

confidence: 99%

Antibacterial Effectiveness of Jatropha Leaf Extract (Jatropha curcas L.) against Aggregatibacter actinomycetemcomitans: In Vitro Study

Lokanata¹,

Molek

Siregar

2023

Bioscmed

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“…11,12 Antibacterial ability of ethanol extract of Pluchea indica (L.) Less related to the active compounds which is flavonoids, phenolics, tannins, alkaloids, lignin glycosides, and triterpenoids that are bacteriostatic and bactericidal. 5,13 Flavonoids work as antibacterials in several ways, such as, inhibiting bacterial cell wall synthesis, membrane disruption, inhibit bacterial protein synthesis, and inhibition of nucleic acid synthesis. 14 The mechanism of phenol was by denaturing the bacterial cell protein.…”

Section: Discussionmentioning

confidence: 99%

“…14 The mechanism of phenol was by denaturing the bacterial cell protein. 13,15 Tanin has an antibacterial effect by forming a complex with proline which is a type of protein in the cell wall of bacteria, which causes protein leakage and damage to bacterial cell walls. 8,13 Alkaloid compounds have inhibitory mechanisms by interfering the constituent components of peptidoglycan in bacterial cells, so the cell wall layer is not formed intact and causes cell death.…”

Section: Discussionmentioning

confidence: 99%

“…13,15 Tanin has an antibacterial effect by forming a complex with proline which is a type of protein in the cell wall of bacteria, which causes protein leakage and damage to bacterial cell walls. 8,13 Alkaloid compounds have inhibitory mechanisms by interfering the constituent components of peptidoglycan in bacterial cells, so the cell wall layer is not formed intact and causes cell death. In addition, in the alkaloid compound there is a nitrogen-containing base group that will act and affect bacterial DNA.…”

Section: Discussionmentioning

confidence: 99%

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Antibacterial activity of ethanol extract of Beluntas leaves on Streptococcus mutans, Porphyromonas gingivalis, and Enterococcus faecalis

et al. 2021

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Introduction: Individuals with poor oral health have a greater risk factor for systemic diseases. Caries, periodontal disease, and root canal infections are a common dental and oral diseases caused by dominance of Streptococcus mutans, Porphyromonas gingivalis, and Enterococcus faecalis bacteria (S. mutans, P. gingivalis, and E. faecalis). An alternative way to prevent dental and oral diseases is to use herbal medicine as one of the active ingredients for mouthwash or toothpaste. One of the herbs that can be used is Beluntas leaves (Pluchea indica (L.) Less leaves). The objective of study was to analyze the antibacterial activity of ethanol extract of Pluchea indica (L.) Less leaves on the growth of Streptococcus mutans, Porphyromonas gingivalis, and Enterococcus faecalis. Methods: This research was experimental laboratory with post test only control design, using disk diffusion method. There were five concentrations (2.5, 3.5, 4.5, 5.5 and 6.5%, positive controls, and negative controls. Data analysis was performed using One Way Anova and post Hoc test. Results: The ethanol extract of Pluchea indica (L.) Less leaves has moderate-strong antibacterial activity against Streptococcus mutans, Porphyromonas gingivalis, and Enterococcus faecalis. The largest diameter of inhibitory zone in Enterococcus faecalis at a concentration of 6.5% followed by Streptococcus mutans and Porphyromonas gingivalis at the same concentration and the smallest diameter of inhibition zone in Porphyromonas gingivalis, followed by Enterococcus faecalis and Streptococcus mutans at 2.5% concentration. Conclusion: The ethanol extract of Pluchea indica (L.) Less leaves with a concentration of 2.5, 3.5, 4.5, 5.5, and 6.5% has antibacterial activity in inhibiting the growth of Streptococcus mutans, Porphyromonas gingivalis, and Enterococcus faecalis.

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“…Maintenance of oral hygiene by methods such as tooth brushing is an inexpensive but effective way to prevent and treat periodontitis (AlAttas, Zahran, & Turkistany, 2016). Nahak, Tedjasulaksana, and Raiyanti (2018) reported that tooth brushing with antibacterial toothpaste reduced the number of periodontal pathogens in the dental plaque. Nigella sativa (N. sativa) is a medicinal plant with a variety of pharmacological effects (Ahmad et al, 2013;Nurhan, Gani, Budiatin, Siswodihardjo, & Khotib, 2021).…”

Section: Introductionmentioning

confidence: 99%

Nigella sativa toothpaste promotes anti-inflammatory and anti-destructive effects in a rat model of periodontitis

Setiawatie

Gani

Rahayu

et al. 2022

Archives of Oral Biology

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Ability difference of Beluntas Leaf (Pluchea indica L) ethanol extract and avocado leaf (Persea americana Mill) ethanol extract in Inhibiting caries-causing Streptococcus mutans Bacteria Growth

Cited by 7 publications

References 0 publications

Antibacterial Effectiveness of Jatropha Leaf Extract (Jatropha curcas L.) against Aggregatibacter actinomycetemcomitans: In Vitro Study

Antibacterial Effectiveness of Jatropha Leaf Extract (Jatropha curcas L.) against Aggregatibacter actinomycetemcomitans: In Vitro Study

Antibacterial activity of ethanol extract of Beluntas leaves on Streptococcus mutans, Porphyromonas gingivalis, and Enterococcus faecalis

Nigella sativa toothpaste promotes anti-inflammatory and anti-destructive effects in a rat model of periodontitis

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