Abietane Diterpenes from Clerodendron cyrtophyllum.

Protein Tyrosine Phosphatase 1B Inhibitors from the Stems of Akebia quinata

“…Activity-guided fractionations of EtOAc soluble fraction were performed by successive chromatographic procedures, including silica gel chromatography, Sephadex LH-20, RP-C 18 and HPLC to afford one new diterpene glycoside (1) and 13 known compounds (2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14) (Figure 1). Figure S1).…”

“…Thus, compound 1 was established as 11-O-(4-O-methyl-β-D-glucopyranosyl)-12-hydroxyabieta-8,11,13-triene-7-one (Table 1). By comparison of the spectroscopic and optical rotation values with the literature data, the 13 known compounds were identified as cyrtophyllones B (2) [10], uncinatone (3) [10], villosin B (4) [11],…”

1H and 13C NMR assignments of abietane diterpenes from Aegiphila lhotzkyana

“…The absolute configuration of 1 was not ascertained; however, it is reasonable to assume that it possesses an absolute stereochemistry belonging to the normal series, considering the abietane diterpenoid skeletons isolated previously from Verbenaceae. 4 Chemical transformations by the usual methods were utilized to obtain the new abietane derivatives 2-4, for which 1 H and 13 C NMR data have so for not been published.…”

“…In folk medicine the oil from fruits has pediculocide and scabicide activities, and the root extract is used as an antidote against snake bites. 3 In our studies of the roots of A. lhotzkyana, we have reported the isolation and structural elucidation of a new abietane diterpenoid (1), along with the known diterpenes uncinatone (5), 4 cyrtophyllone B (6), 4 teuvincenone E (7), 5 sugiol (8) 6 and kaurenoic acid, 7 the steroidˇ-sitosterol glucoside 8 and the triterpene betulinic acid. 9 The complete proton and carbon assignments of the new diterpene (1) and unpublished 13 C NMR data for the new derivatives 2-4, and a suggestion for the 13 C NMR data misassignment related to teuvincenone H 9, were accomplished with the use of a series of 2D NMR experiments including 1 H-1 H COSY, HMQC, HMBC and NOESY sequences.…”

Antiproliferative Effects of Abietane Diterpenes fromAegiphila lhotzkyana

“…Five abietane diterpenes were isolated from a hexane extract obtained from the roots of Aegiphila lhotzkyana and identified as uncinatone, cyrtophyllone B, teunvicenone E, sugiol and 12,16-epoxy-11,14-dihydroxy-6-methoxy-17(15 ± 16)-abeo-abieta-5, 8,11,13,15-pentaene-3,7-dione. The last compound has only been described for this species.…”