Aberrant resting-state functional connectivity of salience network in first-episode schizophrenia

Huang, Huan; Zeng, Botao; Jiang, Yuchao; Tang, Yingying; Zhang, Tianhong; Tang, Xiaochen; Xu, Li-Hua; Wang, Junjie; Li, Jin; Qian, Zhenying; Liu, Xu; Wang, Huiling; Luo, Cheng; Li, Chunbo; Xu, Jian; Goff, Donald C.; Wang, Jijun

doi:10.1007/s11682-019-00040-8

Cited by 40 publications

(38 citation statements)

References 59 publications

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“…Studying the functional connectivity of insula sub-regions in schizophrenia may expand our understanding of the pathophysiology of the disorder and inform the neural substrate of clinical phenotypes (Wylie and Tregellas, 2010). However, the majority of studies looking at the insula in schizophrenia investigated either connectivity of the whole insula (Pang et al, 2017) or within the context of broader cortical resting-state networks that include the insula, such as the salience, cingulo-opercular, and somatosensory networks (Huang et al, 2019;Sheffield et al, 2015). Directed connectivity of the anterior insula (a hub of the salience network) to nodes within the default mode network (DMN) and central executive network is reduced in schizophrenia (Moran et al, 2013;Palaniyappan et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Insula functional connectivity in schizophrenia

Sheffield

Rogers

Blackford

et al. 2020

Schizophrenia Research

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The insula is structurally abnormal in schizophrenia, demonstrating robust reductions in gray matter volume, cortical thickness, and altered gyrification during prodromal, early and chronic stages of the illness. Despite compelling structural alterations, less is known about its functional connectivity, limited by studies considering the insula as a whole or only within the context of resting-state networks. There is evidence, however, from healthy subjects that the insula is comprised of sub-regions with distinct functional profiles, with dorsal anterior insula (dAI) involved in cognitive processing, ventral anterior insula (vAI) involved in affective processing, and posterior insula (PI) involved in somatosensory processing. The current study builds on this prior work and characterizes insula resting-state functional connectivity sub-region profiles in a large cohort of schizophrenia (N=191) and healthy (N=196) participants and hypothesizes specific associations between insula sub-region connectivity abnormalities and clinical characteristics related to their functional profiles. Functional dysconnectivity of the insula in schizophrenia is broadly characterized by reduced connectivity within insula sub-networks and hyper-connectivity with regions not normally connected with that sub-region, reflected in significantly greater similarity of dAI and PI connectivity profiles and significantly lower similarity of dAI and vAI connectivity profiles (p<.05). In schizophrenia, hypo-connectivity of dAI correlates with cognitive function (r=.18, p=.014), whereas hyper-connectivity between vAI and superior temporal sulcus correlates with negative symptoms (r=.27, p<.001). These findings reveal altered insula connectivity in all three sub-regions and converges with recent evidence of reduced differentiation of insula connectivity in schizophrenia, implicating functional dysconnectivity of the insula in cognitive and clinical symptoms.

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Section: Introductionmentioning

confidence: 99%

Insula functional connectivity in schizophrenia

Sheffield

Rogers

Blackford

et al. 2020

Schizophrenia Research

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“…The inverse trend (gray matter increase) has also been reported (Dukart et al, 2017). Data in resting state functional MRI (rs‐fMRI) that compare FEP patients with healthy controls (HC) are also controversial, varying from no differences between groups to regional or diffuse differences (Alonso‐Solis et al, 2012; Argyelan et al, 2015; Bang et al, 2018; Choe et al, 2018; Ganella et al, 2018; Gohel et al, 2018; Huang et al, 2020; Tang et al, 2019). Previous observations of white matter changes have not been consistent.…”

Section: Introductionmentioning

confidence: 99%

MultimodalMRIassessment for first episode psychosis: A major change in the thalamus and an efficient stratification of a subgroup

Faria

Zhao

et al. 2020

Human Brain Mapping

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Multi‐institutional brain imaging studies have emerged to resolve conflicting results among individual studies. However, adjusting multiple variables at the technical and cohort levels is challenging. Therefore, it is important to explore approaches that provide meaningful results from relatively small samples at institutional levels. We studied 87 first episode psychosis (FEP) patients and 62 healthy subjects by combining supervised integrated factor analysis (SIFA) with a novel pipeline for automated structure‐based analysis, an efficient and comprehensive method for dimensional data reduction that our group recently established. We integrated multiple MRI features (volume, DTI indices, resting state fMRI—rsfMRI) in the whole brain of each participant in an unbiased manner. The automated structure‐based analysis showed widespread DTI abnormalities in FEP and rs‐fMRI differences between FEP and healthy subjects mostly centered in thalamus. The combination of multiple modalities with SIFA was more efficient than the use of single modalities to stratify a subgroup of FEP (individuals with schizophrenia or schizoaffective disorder) that had more robust deficits from the overall FEP group. The information from multiple MRI modalities and analytical methods highlighted the thalamus as significantly abnormal in FEP. This study serves as a proof‐of‐concept for the potential of this methodology to reveal disease underpins and to stratify populations into more homogeneous sub‐groups.

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“…The color bar denotes the t-statistic range. The dashed line represents each functional area (DMN, SN and CEN) of the resting network found in previous studies [25][26][27] www.nature.com/scientificreports/ suggest that eye contact plays an important role in the quality of mother-child interactions and that the SN is a major candidate for the neural basis involved in maintaining efficient eye contact. In the resting-state brain function of children, we found that the right AI and the medial frontal gyrus (MFG) were positively associated with the frequency of gaze, and that the right AI was particularly involved in achieving eye contact.…”

Section: Discussionmentioning

confidence: 92%

“…Table 3 and Fig. 1 [25][26][27] . In the eye-gaze condition (one-sided gaze toward the mother), a positive correlation was found in the right AI and the left middle frontal gyrus ( Fig.…”

Section: Resultsmentioning

confidence: 99%

“…The color bar denotes the t-statistic range. The dashed line represents each functional area (DMN, SN and CEN) of the resting network found in previous studies [25][26][27] The statistical threshold for the contrasts was cluster-level P < 0.05 family-wise error corrected for multiple comparisons and voxel-level P < 0.005 uncorrected for height. The color bar denotes the t-statistic range.…”

Section: Discussionmentioning

confidence: 99%

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Intrinsic brain activity associated with eye gaze during mother–child interaction

Kuboshita

Fujisawa

Makita

et al. 2020

Sci Rep

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Mother–child interactions impact child social development and psychological health. This study focused on eye-gaze interactions, especially eye contact as synchronized gaze, which is an important non-verbal communication tool in human interactions. We performed brain-image analysis of mothers and children using resting-state functional magnetic resonance imaging and quantitatively evaluated the quality of mother–child interactions using the Interaction Rating Scale to investigate how it is related to the frequency of mother–child eye contact. As a result, we found a positive correlation between the frequency of eye gaze and the right anterior insula (AI) or middle frontal gyrus in children and a positive correlation with the anterior cingulate cortex (ACC) and precuneus/cuneus in mothers. Especially, when eye contact was made, the association with the right AI in children and ACC in mothers was retained, suggesting the involvement of the salience network responsible for modulating internal and external cognition. In addition, the frequency of eye contact was positively associated with the quality of mother–child interaction. These results suggest that the salience network is a major candidate for the neural basis involved in maintaining efficient eye contact and that it plays an important role in establishing positive mother–child interactions.

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Aberrant resting-state functional connectivity of salience network in first-episode schizophrenia

Cited by 40 publications

References 59 publications

Insula functional connectivity in schizophrenia

Insula functional connectivity in schizophrenia

MultimodalMRIassessment for first episode psychosis: A major change in the thalamus and an efficient stratification of a subgroup

Intrinsic brain activity associated with eye gaze during mother–child interaction

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