Aberrant Notch Signaling Pathway as a Potential Mechanism of Central Precocious Puberty

Shim, Young‐Soo; Lee, Hae Sang; Hwang, Jin Soon

doi:10.3390/ijms23063332

Cited by 11 publications

(12 citation statements)

References 74 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Pubertal failure: Puberty that either fails to begin or has begun but fails to complete (in which case the term mid-pubertal arrest is often used). Primary amenorrhea is defined as the absence of menarche by 16 years of age, and secondary amenorrhea is defined as absence of menses for 6 months after having regular menses [9]. 3.…”

Section: Methodsmentioning

confidence: 99%

Assessment of puberty in children with chronic kidney disease and end-stage renal disease undergoing hemodialysis

Ghobrial

Galal

Gadass

et al. 2022

Egypt Pediatric Association Gaz

View full text Add to dashboard Cite

Background Growth and pubertal retardation are one of the most visible comorbidities in children with chronic kidney disease (CKD) and end-stage renal disease (ESRD) under regular hemodialysis. This study evaluated pubertal development in children and adolescents with CKD and ESRD on regular hemodialysis. Methods This study was carried out on 40 children with CKD and 20 with ESRD under regular hemodialysis. All patients and controls were subjected to a thorough clinical examination pubertal assessment. Results There was a statistically significant difference in the breast or testicular stage of the three groups (P < 0.001). Most cases of ESRD were either stages 1 or 2 (50.0%, 45.0%, respectively). The CKD cases were also stages 1 and 2 (35.7%, 52.4%, respectively). The controls were in stages 3 and 4 (44.3 and 29.5%, respectively), which showed normal development for age. There was a statistically significant difference in the pubic hair stage and axillary hair stage of the three groups (P < 0.001). Most cases of ESRD were either stages 1 or 2 (55.0%, 40.0%, respectively). The CKD cases were also between stages 1 and 2 (38.1%, 52.4%, respectively), with a higher level in stage 2. Of the control group, 39.3% was stage 3, and 36.1% was stage 4, with a higher level in stage 3 proving normal development for age. Conclusion Pubertal growth and sexual maturation in children with CKD and ESRD are markedly affected. It is necessary to regularly follow up with children with ESRD for early detection of endocrinal complications.

show abstract

Section: Methodsmentioning

confidence: 99%

Assessment of puberty in children with chronic kidney disease and end-stage renal disease undergoing hemodialysis

Ghobrial

Galal

Gadass

et al. 2022

Egypt Pediatric Association Gaz

View full text Add to dashboard Cite

show abstract

“…In signal‐receiving cells, receptor protein hydrolysis is triggered by the binding of Notch ligands to receptors. Two further proteolytic cleavages are mediated by the enzymes γ‐secretase and a disintegrin and metalloprotease (ADAM): one in the Notch receptor's transmembrane (ADAM) and the other in the Notch intracellular domain (NICD) from the extracellular domain (γ‐secretase) 167 . The NICD activates downstream target genes by stimulating the TF CBF1 168 .…”

Section: Signaling Pathways In Osmentioning

confidence: 99%

Targeting signaling pathways in osteosarcoma: Mechanisms and clinical studies

Shen

Lan

et al. 2023

MedComm

View full text Add to dashboard Cite

Osteosarcoma (OS) is a highly prevalent bone malignancy among adolescents, accounting for 40% of all primary malignant bone tumors. Neoadjuvant chemotherapy combined with limb‐preserving surgery has effectively reduced patient disability and mortality, but pulmonary metastases and OS cells' resistance to chemotherapeutic agents are pressing challenges in the clinical management of OS. There has been an urgent need to identify new biomarkers for OS to develop specific targeted therapies. Recently, the continued advancements in genomic analysis have contributed to the identification of clinically significant molecular biomarkers for diagnosing OS, acting as therapeutic targets, and predicting prognosis. Additionally, the contemporary molecular classifications have revealed that the signaling pathways, including Wnt/β‐catenin, PI3K/AKT/mTOR, JAK/STAT3, Hippo, Notch, PD‐1/PD‐L1, MAPK, and NF‐κB, have an integral role in OS onset, progression, metastasis, and treatment response. These molecular classifications and biological markers have created new avenues for more accurate OS diagnosis and relevant treatment. We herein present a review of the recent findings for the modulatory role of signaling pathways as possible biological markers and treatment targets for OS. This review also discusses current OS therapeutic approaches, including signaling pathway‐based therapies developed over the past decade. Additionally, the review covers the signaling targets involved in the curative effects of traditional Chinese medicines in the context of expression regulation of relevant genes and proteins through the signaling pathways to inhibit OS cell growth. These findings are expected to provide directions for integrating genomic, molecular, and clinical profiles to enhance OS diagnosis and treatment.

show abstract

“…The Notch receptor is a single transmembrane protein that mainly includes Notch1, Notch2, Notch3 and Notch4 members in mammals. The Notch receptor extracellular end contains 29 to 36 EGF-like repeats, which may mediate Notch receptor and ligand interactions[ 57 ]. In mammals, Notch signaling ligands also contain multiple members, including Jagged1, Jagged2, Dll1, Dll3 and Dll4.…”

Section: Self-renewal Of Small Iscs and Small Intestinal Epitheliummentioning

confidence: 99%

Molecular regulation mechanism of intestinal stem cells in mucosal injury and repair in ulcerative colitis

Zheng¹,

Duan²

2023

World J Gastroenterol

View full text Add to dashboard Cite

Ulcerative colitis (UC) is a chronic nonspecific inflammatory disease with complex causes. The main pathological changes were intestinal mucosal injury. Leucine-rich repeat-containing G protein coupled receptor 5 (LGR5)-labeled small intestine stem cells (ISCs) were located at the bottom of the small intestine recess and inlaid among Paneth cells. LGR5+ small ISCs are active proliferative adult stem cells, and their self-renewal, proliferation and differentiation disorders are closely related to the occurrence of intestinal inflammatory diseases. The Notch signaling pathway and Wnt/β-catenin signaling pathway are important regulators of LGR5-positive ISCs and together maintain the function of LGR5-positive ISCs. More importantly, the surviving stem cells after intestinal mucosal injury accelerate division, restore the number of stem cells, multiply and differentiate into mature intestinal epithelial cells, and repair the damaged intestinal mucosa. Therefore, in-depth study of multiple pathways and transplantation of LGR5-positive ISCs may become a new target for the treatment of UC.

show abstract

Aberrant Notch Signaling Pathway as a Potential Mechanism of Central Precocious Puberty

Cited by 11 publications

References 74 publications

Assessment of puberty in children with chronic kidney disease and end-stage renal disease undergoing hemodialysis

Assessment of puberty in children with chronic kidney disease and end-stage renal disease undergoing hemodialysis

Targeting signaling pathways in osteosarcoma: Mechanisms and clinical studies

Molecular regulation mechanism of intestinal stem cells in mucosal injury and repair in ulcerative colitis

Contact Info

Product

Resources

About