2019
DOI: 10.1101/736090
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Aberrant newborn T cell and microbiota developmental trajectories predict respiratory compromise during infancy

Abstract: Neonatal immune-microbiota co-development is poorly understood, yet appropriate recognition of -and response to -pathogens and commensal microbiota is critical to health. In this longitudinal study of 133 pre-and 79 full-term infants from birth through one year of age we found that postmenstrual age, or weeks from conception, is the dominant factor influencing T cell and mucosal microbiota development. However, numerous features of the T cell and microbiota trajectories remain unexplained by host age, and are … Show more

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Cited by 2 publications
(3 citation statements)
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“…However, once this work was complete, we integrated microbiome measurements from multiple body sites, flow cytometry-base T cell assays, and clinical data often by simply joining on visit number and participant ID, sometimes in conjunction with simple data imputation techniques for data sampled on an irregular grid, such as last-observation-carriedforward. This analyses revealed evidence for microbial interaction between body sites, predictive in cross-validation, even after stringent control for the effect of host development [26], as well as a subset of T cells that were associated with inflammatory insults that occurred as early as birth [29].…”
Section: Resultsmentioning
confidence: 91%
“…However, once this work was complete, we integrated microbiome measurements from multiple body sites, flow cytometry-base T cell assays, and clinical data often by simply joining on visit number and participant ID, sometimes in conjunction with simple data imputation techniques for data sampled on an irregular grid, such as last-observation-carriedforward. This analyses revealed evidence for microbial interaction between body sites, predictive in cross-validation, even after stringent control for the effect of host development [26], as well as a subset of T cells that were associated with inflammatory insults that occurred as early as birth [29].…”
Section: Resultsmentioning
confidence: 91%
“…Indeed, there is an exponential relationship between total IgG and GA in preterm infants [75]. More generally, GA appears to be an important parameter that influences immune cell differentiation in the neonate and not only in preterm infants [76]. Indeed, even if several studies mentioned before show great differences in immune cell populations or cytokine profiles between preterm and full-term children at birth, those differences are lost as the child grows [73].…”
Section: Preterm Vs Term Deliverymentioning
confidence: 98%
“…In humans, a recent study demonstrated that prenatal antibiotic treatment or neonatal infections disrupt not only the microbiota but also the normal T cell population developmental trajectory. In infants whose microbial colonization was disrupted, the risk for respiratory morbidity is significantly increased [76]. The immune development and the absence or presence of disease is dependent on microbial colonization and on the perturbations of the maternal microbiota.…”
Section: Neonate Colonization and Role Of The Breastfeedingmentioning
confidence: 99%