Aberrant methylation of secreted protein, acidic and rich in cysteine in human laryngeal and hypopharyngeal carcinoma

He, Qian; Wei, Jiazhang; Zhang, Jinyan; Jiang, Heng; Wang, Shumin; Zhou, Xiaoying; Zhang, Zhe; Huang, Guangwu; Watanabe, Hiroshi; Su, Jiping

doi:10.3892/ol.2011.297

Cited by 9 publications

(5 citation statements)

References 24 publications

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“…However, other studies suggested that SPARC induced endoplasmic reticulum stress leading to autophagy-mediated apoptosis in neuroblastoma (12), and RNA interference against SPARC promoted the growth of malignant glioma cells (13). The aberrant methylation of SPARC was identified in human laryngeal and hypopharyngeal carcinomas (71). In addition, SPARC was observed to be involved in the transformation of hamster oral mucosa from precancerous lesions to squamous cell carcinoma (72,73).…”

Section: Discussionmentioning

confidence: 99%

Integrative genomic analyses of secreted protein acidic and rich in cysteine and its role in cancer prediction

Wang

Chen

et al. 2014

Molecular Medicine Reports

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Secreted protein acidic and rich in cysteine (SPARC), also termed osteonectin or basement‑membrane‑40 (BM‑40), is a matrix‑associated protein that elicits changes in cell shape, inhibits cell‑cycle progression and affects the synthesis of extracellular matrix (ECM). The final mature SPARC protein has 286 amino acids with three distinct domains, including an NH2‑terminal acidic domain (NT), follistatin‑like domain (FS) and C terminus domain (EC). The present study identified SPARC genes from 14 vertebrate genomes and revealed that SPARC existed in all types of vertebrates, including fish, amphibians, birds and mammals. In total, 21 single nucleotide polymorphisms (SNPs) causing missense mutations were identified, which may affect the formation of the truncated form of the SPARC protein. The human SPARC gene was found to be expressed in numerous tissues or organs, including in the bone marrow, whole blood, lymph node, thymus, brain, cerebellum, retina, heart, smooth muscle, skeletal muscle, spinal cord, intestine, colon, adipocyte, kidney, liver, pancreas, thyroid, salivary gland, skin, ovary, uterus, placenta, cervix and prostate. When searched in the PrognoScan database, the human SPARC gene was also found to be expressed in bladder, blood, breast, glioma, esophagus, colorectal, head and neck, ovarian, lung and skin cancer tissues. It was revealed that the association between the expression of SPARC and prognosis varied in different types of cancer, and even in the same cancer from different databases. It implied that the function of SPARC in these tumors may be multidimensional, functioning not just as a tumor suppressor or oncogene.

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Section: Discussionmentioning

confidence: 99%

Integrative genomic analyses of secreted protein acidic and rich in cysteine and its role in cancer prediction

Wang

Chen

et al. 2014

Molecular Medicine Reports

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“…The same role for the molecule was demonstrated in ESCC, in which high SPARC expression closely associates with ESCC metastasis [ 132 ]. Overall, the level of SPARC in the UADT SCC TME represents a potential predictor of poor prognosis and has been shown also to associate with impaired sensitivity to chemotherapy [ 133 ]. All these evidence prompted to propose SPARC as a therapeutic target for these types of tumors [ 134 ].…”

Section: Ecm In Uadt Scc: An Intertwined Storymentioning

confidence: 99%

ECM Remodeling in Squamous Cell Carcinoma of the Aerodigestive Tract: Pathways for Cancer Dissemination and Emerging Biomarkers

Fejza

Camicia

Poletto

et al. 2021

Cancers

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Squamous cell carcinomas (SCC) include a number of different types of tumors developing in the skin, in hollow organs, as well as the upper aerodigestive tract (UADT) including the head and neck region and the esophagus which will be dealt with in this review. These tumors are often refractory to current therapeutic approaches with poor patient outcome. The most important prognostic determinant of SCC tumors is the presence of distant metastasis, significantly correlating with low patient survival rates. Rapidly emerging evidence indicate that the extracellular matrix (ECM) composition and remodeling profoundly affect SSC metastatic dissemination. In this review, we will summarize the current knowledge on the role of ECM and its remodeling enzymes in affecting the growth and dissemination of UADT SCC. Taken together, these published evidence suggest that a thorough analysis of the ECM composition in the UADT SCC microenvironment may help disclosing the mechanism of resistance to the treatments and help defining possible targets for clinical intervention.

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“…It is silenced through promoter methylation in metastatic and aggressive prostate cancer cells, with its promoter hypermethylation inversely correlating with prostate cancer patients’ disease-free survival [85]. Hypermthylation-induced silencing of SPARC has also been reported in pancreatic cancer [86], ovarian cancer [87] hepatocellular carcinoma [88] and laryngeal and hypopharyngeal carcinomas [89]. Low TIMP3 expression in many cancers, including prostate cancer, has been demonstrated to facilitate metastatic potential of tumor cells, due to an increase in the activity of matrix metalloproteinase activity in the tumor microenvironment [90].…”

Section: Epigenetics In Cancer Health Disparitiesmentioning

confidence: 99%

Epigenetic basis of cancer health disparities: Looking beyond genetic differences

Ahmad

Azim

Zubair

et al. 2017

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer

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Despite efforts at various levels, racial health disparities still exist in cancer patients. These inequalities in incidence and/or clinical outcome can only be explained by a multitude of factors, with genetic basis being one of them. Several investigations have provided convincing evidence to support epigenetic regulation of cancer-associated genes, which results in the differential transcriptome and proteome, and may be linked to a pre-disposition of individuals of certain race/ethnicity to early or more aggressive cancers. Recent technological advancements and the ability to quickly analyze whole genome have aided in these efforts, and owing to their relatively easy detection, methylation events are much well-characterized, than the acetylation events, across human populations. The early trend of investigating a pre-determined set of genes for differential epigenetic regulation is paving way for more unbiased screening. This review summarizes our current understanding of the epigenetic events that have been tied to the racial differences in cancer incidence and mortality. A better understanding of the epigenetics of racial diversity holds promise for the design and execution of novel strategies targeting the human epigenome for reducing the disparity gaps.

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Aberrant methylation of secreted protein, acidic and rich in cysteine in human laryngeal and hypopharyngeal carcinoma

Cited by 9 publications

References 24 publications

Integrative genomic analyses of secreted protein acidic and rich in cysteine and its role in cancer prediction

Integrative genomic analyses of secreted protein acidic and rich in cysteine and its role in cancer prediction

ECM Remodeling in Squamous Cell Carcinoma of the Aerodigestive Tract: Pathways for Cancer Dissemination and Emerging Biomarkers

Epigenetic basis of cancer health disparities: Looking beyond genetic differences

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